node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FBP1 | FBP2 | ENSP00000364475 | ENSP00000364486 | fructose-1,6-bisphosphatase 1 | fructose-1,6-bisphosphatase 2 | 0.821 |
FBP1 | GPI | ENSP00000364475 | ENSP00000405573 | fructose-1,6-bisphosphatase 1 | glucose-6-phosphate isomerase; Besides it’s role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons | 0.955 |
FBP1 | HKDC1 | ENSP00000364475 | ENSP00000346643 | fructose-1,6-bisphosphatase 1 | hexokinase domain containing 1 | 0.946 |
FBP1 | PFKFB1 | ENSP00000364475 | ENSP00000364145 | fructose-1,6-bisphosphatase 1 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1; Synthesis and degradation of fructose 2,6-bisphosphate | 0.953 |
FBP1 | PFKFB2 | ENSP00000364475 | ENSP00000356047 | fructose-1,6-bisphosphatase 1 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2; Synthesis and degradation of fructose 2,6-bisphosphate | 0.951 |
FBP1 | PFKFB3 | ENSP00000364475 | ENSP00000369100 | fructose-1,6-bisphosphatase 1 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3; Synthesis and degradation of fructose 2,6-bisphosphate | 0.947 |
FBP1 | PFKL | ENSP00000364475 | ENSP00000269848 | fructose-1,6-bisphosphatase 1 | phosphofructokinase, liver; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP | 0.831 |
FBP1 | PFKM | ENSP00000364475 | ENSP00000345771 | fructose-1,6-bisphosphatase 1 | phosphofructokinase, muscle; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP | 0.830 |
FBP1 | PFKP | ENSP00000364475 | ENSP00000370517 | fructose-1,6-bisphosphatase 1 | phosphofructokinase, platelet; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP | 0.824 |
FBP1 | PGM1 | ENSP00000364475 | ENSP00000360124 | fructose-1,6-bisphosphatase 1 | phosphoglucomutase 1 | 0.434 |
FBP2 | FBP1 | ENSP00000364486 | ENSP00000364475 | fructose-1,6-bisphosphatase 2 | fructose-1,6-bisphosphatase 1 | 0.821 |
FBP2 | GPI | ENSP00000364486 | ENSP00000405573 | fructose-1,6-bisphosphatase 2 | glucose-6-phosphate isomerase; Besides it’s role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons | 0.957 |
FBP2 | HKDC1 | ENSP00000364486 | ENSP00000346643 | fructose-1,6-bisphosphatase 2 | hexokinase domain containing 1 | 0.946 |
FBP2 | PFKFB1 | ENSP00000364486 | ENSP00000364145 | fructose-1,6-bisphosphatase 2 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1; Synthesis and degradation of fructose 2,6-bisphosphate | 0.957 |
FBP2 | PFKFB2 | ENSP00000364486 | ENSP00000356047 | fructose-1,6-bisphosphatase 2 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2; Synthesis and degradation of fructose 2,6-bisphosphate | 0.953 |
FBP2 | PFKFB3 | ENSP00000364486 | ENSP00000369100 | fructose-1,6-bisphosphatase 2 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3; Synthesis and degradation of fructose 2,6-bisphosphate | 0.951 |
FBP2 | PFKL | ENSP00000364486 | ENSP00000269848 | fructose-1,6-bisphosphatase 2 | phosphofructokinase, liver; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP | 0.861 |
FBP2 | PFKM | ENSP00000364486 | ENSP00000345771 | fructose-1,6-bisphosphatase 2 | phosphofructokinase, muscle; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP | 0.854 |
FBP2 | PFKP | ENSP00000364486 | ENSP00000370517 | fructose-1,6-bisphosphatase 2 | phosphofructokinase, platelet; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP | 0.854 |
FBP2 | PGM1 | ENSP00000364486 | ENSP00000360124 | fructose-1,6-bisphosphatase 2 | phosphoglucomutase 1 | 0.504 |