node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GPR143 | MC1R | ENSP00000417161 | ENSP00000451605 | G protein-coupled receptor 143; Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand- dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Plays also a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) | 0.420 |
GPR143 | OCA2 | ENSP00000417161 | ENSP00000346659 | G protein-coupled receptor 143; Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand- dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Plays also a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport | oculocutaneous albinism II; Could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color | 0.724 |
GPR143 | SLC24A5 | ENSP00000417161 | ENSP00000341550 | G protein-coupled receptor 143; Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand- dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Plays also a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport | solute carrier family 24, member 5; Cation exchanger involved in pigmentation, possibly by participating in ion transport in melanosomes. Probably transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) | 0.442 |
GPR143 | SLC45A2 | ENSP00000417161 | ENSP00000296589 | G protein-coupled receptor 143; Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand- dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Plays also a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport | solute carrier family 45, member 2; Melanocyte differentiation antigen. May transport substances required for melanin biosynthesis (By similarity) | 0.508 |
GPR143 | TYR | ENSP00000417161 | ENSP00000263321 | G protein-coupled receptor 143; Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand- dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Plays also a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport | tyrosinase; This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone | 0.644 |
GPR143 | TYRP1 | ENSP00000417161 | ENSP00000373570 | G protein-coupled receptor 143; Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand- dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Plays also a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport | tyrosinase-related protein 1; Oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized | 0.606 |
HERC2 | MC1R | ENSP00000261609 | ENSP00000451605 | HECT and RLD domain containing E3 ubiquitin protein ligase 2 | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) | 0.567 |
HERC2 | OCA2 | ENSP00000261609 | ENSP00000346659 | HECT and RLD domain containing E3 ubiquitin protein ligase 2 | oculocutaneous albinism II; Could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color | 0.760 |
HERC2 | SLC24A4 | ENSP00000261609 | ENSP00000431840 | HECT and RLD domain containing E3 ubiquitin protein ligase 2 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 4; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) | 0.609 |
HERC2 | SLC24A5 | ENSP00000261609 | ENSP00000341550 | HECT and RLD domain containing E3 ubiquitin protein ligase 2 | solute carrier family 24, member 5; Cation exchanger involved in pigmentation, possibly by participating in ion transport in melanosomes. Probably transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) | 0.619 |
HERC2 | SLC45A2 | ENSP00000261609 | ENSP00000296589 | HECT and RLD domain containing E3 ubiquitin protein ligase 2 | solute carrier family 45, member 2; Melanocyte differentiation antigen. May transport substances required for melanin biosynthesis (By similarity) | 0.563 |
HERC2 | TUBB3 | ENSP00000261609 | ENSP00000451560 | HECT and RLD domain containing E3 ubiquitin protein ligase 2 | tubulin, beta 3 class III; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity) | 0.463 |
KIAA1279 | OCA2 | ENSP00000354848 | ENSP00000346659 | KIAA1279; Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development. Regulates mitochondrial transport by modulating KIF1B motor activity | oculocutaneous albinism II; Could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color | 0.649 |
KIAA1279 | SLC45A2 | ENSP00000354848 | ENSP00000296589 | KIAA1279; Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development. Regulates mitochondrial transport by modulating KIF1B motor activity | solute carrier family 45, member 2; Melanocyte differentiation antigen. May transport substances required for melanin biosynthesis (By similarity) | 0.608 |
MC1R | GPR143 | ENSP00000451605 | ENSP00000417161 | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) | G protein-coupled receptor 143; Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand- dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Plays also a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport | 0.420 |
MC1R | HERC2 | ENSP00000451605 | ENSP00000261609 | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) | HECT and RLD domain containing E3 ubiquitin protein ligase 2 | 0.567 |
MC1R | OCA2 | ENSP00000451605 | ENSP00000346659 | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) | oculocutaneous albinism II; Could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color | 0.823 |
MC1R | SLC24A4 | ENSP00000451605 | ENSP00000431840 | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) | solute carrier family 24 (sodium/potassium/calcium exchanger), member 4; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) | 0.561 |
MC1R | SLC24A5 | ENSP00000451605 | ENSP00000341550 | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) | solute carrier family 24, member 5; Cation exchanger involved in pigmentation, possibly by participating in ion transport in melanosomes. Probably transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) | 0.700 |
MC1R | SLC45A2 | ENSP00000451605 | ENSP00000296589 | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) | solute carrier family 45, member 2; Melanocyte differentiation antigen. May transport substances required for melanin biosynthesis (By similarity) | 0.658 |