node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACAP3 | ARFGAP1 | ENSP00000346733 | ENSP00000314615 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 3; GTPase-activating protein for the ADP ribosylation factor family (Potential) | ADP-ribosylation factor GTPase activating protein 1 | 0.708 |
ACAP3 | RAB11A | ENSP00000346733 | ENSP00000261890 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 3; GTPase-activating protein for the ADP ribosylation factor family (Potential) | RAB11A, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polariza [...] | 0.633 |
ACAP3 | RAB11B | ENSP00000346733 | ENSP00000333547 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 3; GTPase-activating protein for the ADP ribosylation factor family (Potential) | RAB11B, member RAS oncogene family; GTPase that modulates endosomal trafficking. Acts as a major regulator of membrane delivery during cytokinesis (By similarity) | 0.633 |
ACAP3 | RAB11FIP3 | ENSP00000346733 | ENSP00000262305 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 3; GTPase-activating protein for the ADP ribosylation factor family (Potential) | RAB11 family interacting protein 3 (class II) | 0.593 |
ACAP3 | RAB11FIP4 | ENSP00000346733 | ENSP00000312837 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 3; GTPase-activating protein for the ADP ribosylation factor family (Potential) | RAB11 family interacting protein 4 (class II); Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an ’address tag’ delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. In case of infection by HCMV (human cytomegalovirus), may participate in egress of the virus out of nucleus; this function is independent of ARF6 | 0.593 |
ACAP3 | RAB25 | ENSP00000346733 | ENSP00000354376 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 3; GTPase-activating protein for the ADP ribosylation factor family (Potential) | RAB25, member RAS oncogene family; Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia. Increases the rates of ovarian and breast cancers progression and aggressiveness by modulating cellular processes such as proliferation, survival and migration of epithelial tumor cells. May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis (By similarity) | 0.633 |
ACAP3 | RABL2A | ENSP00000346733 | ENSP00000376871 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 3; GTPase-activating protein for the ADP ribosylation factor family (Potential) | RAB, member of RAS oncogene family-like 2A | 0.633 |
ACAP3 | RABL2B | ENSP00000346733 | ENSP00000378958 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 3; GTPase-activating protein for the ADP ribosylation factor family (Potential) | RAB, member of RAS oncogene family-like 2B | 0.633 |
ACAP3 | STX12 | ENSP00000346733 | ENSP00000363054 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 3; GTPase-activating protein for the ADP ribosylation factor family (Potential) | syntaxin 12; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity) | 0.624 |
ACAP3 | UBE2J2 | ENSP00000346733 | ENSP00000383719 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 3; GTPase-activating protein for the ADP ribosylation factor family (Potential) | ubiquitin-conjugating enzyme E2, J2; Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD) (By similarity) | 0.691 |
ARFGAP1 | ACAP3 | ENSP00000314615 | ENSP00000346733 | ADP-ribosylation factor GTPase activating protein 1 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 3; GTPase-activating protein for the ADP ribosylation factor family (Potential) | 0.708 |
ARFGAP1 | RAB11A | ENSP00000314615 | ENSP00000261890 | ADP-ribosylation factor GTPase activating protein 1 | RAB11A, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polariza [...] | 0.580 |
ARFGAP1 | RAB11B | ENSP00000314615 | ENSP00000333547 | ADP-ribosylation factor GTPase activating protein 1 | RAB11B, member RAS oncogene family; GTPase that modulates endosomal trafficking. Acts as a major regulator of membrane delivery during cytokinesis (By similarity) | 0.486 |
RAB11A | ACAP3 | ENSP00000261890 | ENSP00000346733 | RAB11A, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polariza [...] | ArfGAP with coiled-coil, ankyrin repeat and PH domains 3; GTPase-activating protein for the ADP ribosylation factor family (Potential) | 0.633 |
RAB11A | ARFGAP1 | ENSP00000261890 | ENSP00000314615 | RAB11A, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polariza [...] | ADP-ribosylation factor GTPase activating protein 1 | 0.580 |
RAB11A | RAB11B | ENSP00000261890 | ENSP00000333547 | RAB11A, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polariza [...] | RAB11B, member RAS oncogene family; GTPase that modulates endosomal trafficking. Acts as a major regulator of membrane delivery during cytokinesis (By similarity) | 0.949 |
RAB11A | RAB11FIP3 | ENSP00000261890 | ENSP00000262305 | RAB11A, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polariza [...] | RAB11 family interacting protein 3 (class II) | 0.999 |
RAB11A | RAB11FIP4 | ENSP00000261890 | ENSP00000312837 | RAB11A, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polariza [...] | RAB11 family interacting protein 4 (class II); Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an ’address tag’ delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. In case of infection by HCMV (human cytomegalovirus), may participate in egress of the virus out of nucleus; this function is independent of ARF6 | 0.996 |
RAB11A | STX12 | ENSP00000261890 | ENSP00000363054 | RAB11A, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polariza [...] | syntaxin 12; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity) | 0.577 |
RAB11B | ACAP3 | ENSP00000333547 | ENSP00000346733 | RAB11B, member RAS oncogene family; GTPase that modulates endosomal trafficking. Acts as a major regulator of membrane delivery during cytokinesis (By similarity) | ArfGAP with coiled-coil, ankyrin repeat and PH domains 3; GTPase-activating protein for the ADP ribosylation factor family (Potential) | 0.633 |