CRYBA4 protein (Homo sapiens) - STRING network view

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protein of unknown 3D structure

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Score

CRYBA4

crystallin, beta A4; Crystallins are the dominant structural components of the vertebrate eye lens (196 aa)

Predicted Functional Partners:

HSPB1

0.917

DNAJB1

0.906

HSPH1

0.903

HSPA8

0.900

DEDD2

0.900

HSBP1

0.900

RPA2

0.900

COL4A6

0.900

MRPL18

0.900

SERPINH1

0.900

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
COL4A6	CRYBA4	ENSP00000361290	ENSP00000346805	collagen, type IV, alpha 6	crystallin, beta A4; Crystallins are the dominant structural components of the vertebrate eye lens	0.900
COL4A6	DEDD2	ENSP00000361290	ENSP00000470082	collagen, type IV, alpha 6	death effector domain containing 2; May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3	0.900
COL4A6	DNAJB1	ENSP00000361290	ENSP00000254322	collagen, type IV, alpha 6	DnaJ (Hsp40) homolog, subfamily B, member 1; Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP	0.900
COL4A6	HSBP1	ENSP00000361290	ENSP00000392896	collagen, type IV, alpha 6	heat shock factor binding protein 1; Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process	0.900
COL4A6	HSPA8	ENSP00000361290	ENSP00000227378	collagen, type IV, alpha 6	heat shock 70kDa protein 8; Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19- CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex	0.905
COL4A6	HSPB1	ENSP00000361290	ENSP00000248553	collagen, type IV, alpha 6	heat shock 27kDa protein 1	0.900
COL4A6	HSPH1	ENSP00000361290	ENSP00000318687	collagen, type IV, alpha 6	heat shock 105kDa/110kDa protein 1; Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity)	0.900
COL4A6	MRPL18	ENSP00000361290	ENSP00000356001	collagen, type IV, alpha 6	mitochondrial ribosomal protein L18; Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA	0.900
COL4A6	RPA2	ENSP00000361290	ENSP00000363021	collagen, type IV, alpha 6	replication protein A2, 32kDa; Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions. Required for the efficient recruitment of the DNA double-strand break repair factor RAD51 to chromatin in response to DNA damage	0.900
COL4A6	SERPINH1	ENSP00000361290	ENSP00000350894	collagen, type IV, alpha 6	serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1); Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen	0.903
CRYBA4	COL4A6	ENSP00000346805	ENSP00000361290	crystallin, beta A4; Crystallins are the dominant structural components of the vertebrate eye lens	collagen, type IV, alpha 6	0.900
CRYBA4	DEDD2	ENSP00000346805	ENSP00000470082	crystallin, beta A4; Crystallins are the dominant structural components of the vertebrate eye lens	death effector domain containing 2; May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3	0.900
CRYBA4	DNAJB1	ENSP00000346805	ENSP00000254322	crystallin, beta A4; Crystallins are the dominant structural components of the vertebrate eye lens	DnaJ (Hsp40) homolog, subfamily B, member 1; Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP	0.906
CRYBA4	HSBP1	ENSP00000346805	ENSP00000392896	crystallin, beta A4; Crystallins are the dominant structural components of the vertebrate eye lens	heat shock factor binding protein 1; Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process	0.900
CRYBA4	HSPA8	ENSP00000346805	ENSP00000227378	crystallin, beta A4; Crystallins are the dominant structural components of the vertebrate eye lens	heat shock 70kDa protein 8; Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19- CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex	0.900
CRYBA4	HSPB1	ENSP00000346805	ENSP00000248553	crystallin, beta A4; Crystallins are the dominant structural components of the vertebrate eye lens	heat shock 27kDa protein 1	0.917
CRYBA4	HSPH1	ENSP00000346805	ENSP00000318687	crystallin, beta A4; Crystallins are the dominant structural components of the vertebrate eye lens	heat shock 105kDa/110kDa protein 1; Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity)	0.903
CRYBA4	MRPL18	ENSP00000346805	ENSP00000356001	crystallin, beta A4; Crystallins are the dominant structural components of the vertebrate eye lens	mitochondrial ribosomal protein L18; Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA	0.900
CRYBA4	RPA2	ENSP00000346805	ENSP00000363021	crystallin, beta A4; Crystallins are the dominant structural components of the vertebrate eye lens	replication protein A2, 32kDa; Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions. Required for the efficient recruitment of the DNA double-strand break repair factor RAD51 to chromatin in response to DNA damage	0.900
CRYBA4	SERPINH1	ENSP00000346805	ENSP00000350894	crystallin, beta A4; Crystallins are the dominant structural components of the vertebrate eye lens	serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1); Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen	0.900

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