| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BDP1 | SERF1A | ENSP00000351575 | ENSP00000346892 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | small EDRK-rich factor 1A (telomeric) | 0.667 |
| GTF2H2 | SERF1A | ENSP00000274400 | ENSP00000346892 | general transcription factor IIH, polypeptide 2, 44kDa; Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. The N-terminus interacts with and regulates XPD whereas an intact C- terminus is required for a successful escape of RNAP II form the promoter | small EDRK-rich factor 1A (telomeric) | 0.412 |
| GTF2H2 | SMN1 | ENSP00000274400 | ENSP00000370083 | general transcription factor IIH, polypeptide 2, 44kDa; Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. The N-terminus interacts with and regulates XPD whereas an intact C- terminus is required for a successful escape of RNAP II form the promoter | survival of motor neuron 1, telomeric; The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. It may also play a role in the metabolism of snoRNPs | 0.459 |
| GTF2H2 | SMN2 | ENSP00000274400 | ENSP00000370119 | general transcription factor IIH, polypeptide 2, 44kDa; Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. The N-terminus interacts with and regulates XPD whereas an intact C- terminus is required for a successful escape of RNAP II form the promoter | survival of motor neuron 2, centromeric | 0.472 |
| NAIP | SERF1A | ENSP00000428657 | ENSP00000346892 | NLR family, apoptosis inhibitory protein; Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at ’Asp-315’ and decreasing the rate of auto proteolysis at ’Asp-330’. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor- neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apopt [...] | small EDRK-rich factor 1A (telomeric) | 0.686 |
| NAIP | SMN1 | ENSP00000428657 | ENSP00000370083 | NLR family, apoptosis inhibitory protein; Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at ’Asp-315’ and decreasing the rate of auto proteolysis at ’Asp-330’. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor- neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apopt [...] | survival of motor neuron 1, telomeric; The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. It may also play a role in the metabolism of snoRNPs | 0.676 |
| NAIP | SMN2 | ENSP00000428657 | ENSP00000370119 | NLR family, apoptosis inhibitory protein; Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at ’Asp-315’ and decreasing the rate of auto proteolysis at ’Asp-330’. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor- neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apopt [...] | survival of motor neuron 2, centromeric | 0.599 |
| SERF1A | BDP1 | ENSP00000346892 | ENSP00000351575 | small EDRK-rich factor 1A (telomeric) | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | 0.667 |
| SERF1A | GTF2H2 | ENSP00000346892 | ENSP00000274400 | small EDRK-rich factor 1A (telomeric) | general transcription factor IIH, polypeptide 2, 44kDa; Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. The N-terminus interacts with and regulates XPD whereas an intact C- terminus is required for a successful escape of RNAP II form the promoter | 0.412 |
| SERF1A | NAIP | ENSP00000346892 | ENSP00000428657 | small EDRK-rich factor 1A (telomeric) | NLR family, apoptosis inhibitory protein; Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at ’Asp-315’ and decreasing the rate of auto proteolysis at ’Asp-330’. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor- neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apopt [...] | 0.686 |
| SERF1A | SMN1 | ENSP00000346892 | ENSP00000370083 | small EDRK-rich factor 1A (telomeric) | survival of motor neuron 1, telomeric; The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. It may also play a role in the metabolism of snoRNPs | 0.826 |
| SERF1A | SMN2 | ENSP00000346892 | ENSP00000370119 | small EDRK-rich factor 1A (telomeric) | survival of motor neuron 2, centromeric | 0.712 |
| SERF1A | SRPK1 | ENSP00000346892 | ENSP00000362931 | small EDRK-rich factor 1A (telomeric) | SRSF protein kinase 1; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activiti [...] | 0.461 |
| SERF1A | SRPK2 | ENSP00000346892 | ENSP00000377262 | small EDRK-rich factor 1A (telomeric) | SRSF protein kinase 2; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and [...] | 0.461 |
| SMN1 | GTF2H2 | ENSP00000370083 | ENSP00000274400 | survival of motor neuron 1, telomeric; The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. It may also play a role in the metabolism of snoRNPs | general transcription factor IIH, polypeptide 2, 44kDa; Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. The N-terminus interacts with and regulates XPD whereas an intact C- terminus is required for a successful escape of RNAP II form the promoter | 0.459 |
| SMN1 | NAIP | ENSP00000370083 | ENSP00000428657 | survival of motor neuron 1, telomeric; The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. It may also play a role in the metabolism of snoRNPs | NLR family, apoptosis inhibitory protein; Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at ’Asp-315’ and decreasing the rate of auto proteolysis at ’Asp-330’. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor- neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apopt [...] | 0.676 |
| SMN1 | SERF1A | ENSP00000370083 | ENSP00000346892 | survival of motor neuron 1, telomeric; The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. It may also play a role in the metabolism of snoRNPs | small EDRK-rich factor 1A (telomeric) | 0.826 |
| SMN1 | SMN2 | ENSP00000370083 | ENSP00000370119 | survival of motor neuron 1, telomeric; The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. It may also play a role in the metabolism of snoRNPs | survival of motor neuron 2, centromeric | 0.900 |
| SMN2 | GTF2H2 | ENSP00000370119 | ENSP00000274400 | survival of motor neuron 2, centromeric | general transcription factor IIH, polypeptide 2, 44kDa; Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. The N-terminus interacts with and regulates XPD whereas an intact C- terminus is required for a successful escape of RNAP II form the promoter | 0.472 |
| SMN2 | NAIP | ENSP00000370119 | ENSP00000428657 | survival of motor neuron 2, centromeric | NLR family, apoptosis inhibitory protein; Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at ’Asp-315’ and decreasing the rate of auto proteolysis at ’Asp-330’. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor- neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apopt [...] | 0.599 |
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