| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACLY | DPYD | ENSP00000253792 | ENSP00000359211 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | dihydropyrimidine dehydrogenase | 0.940 |
| ACLY | GMPS | ENSP00000253792 | ENSP00000419851 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | guanine monphosphate synthetase; Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division | 0.414 |
| ACLY | SLC32A1 | ENSP00000253792 | ENSP00000217420 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | solute carrier family 32 (GABA vesicular transporter), member 1; Involved in the uptake of GABA and glycine into the synaptic vesicles | 0.591 |
| ACLY | SLC36A1 | ENSP00000253792 | ENSP00000243389 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | solute carrier family 36 (proton/amino acid symporter), member 1; Neutral amino acid/proton symporter. Has a pH-dependent electrogenic transport activity for small amino acids such as glycine, alanine and proline. Besides small apolar L-amino acids, it also recognize their D-enantiomers and selected amino acid derivatives such as gamma-aminobutyric acid (By similarity) | 0.591 |
| ACLY | SLC36A2 | ENSP00000253792 | ENSP00000334223 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | solute carrier family 36 (proton/amino acid symporter), member 2; Involved in a pH-dependent electrogenic neuronal transport and sequestration of small amino acids. Transports glycine and proline. Inhibited by sarcosine (By similarity) | 0.595 |
| ACLY | SLC36A3 | ENSP00000253792 | ENSP00000366942 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | solute carrier family 36 (proton/amino acid symporter), member 3 | 0.591 |
| ACLY | SLC38A6 | ENSP00000253792 | ENSP00000346959 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | solute carrier family 38, member 6; Probable sodium-dependent amino acid/proton antiporter | 0.591 |
| C14orf39 | SLC38A6 | ENSP00000324920 | ENSP00000346959 | chromosome 14 open reading frame 39; May be involved in eye development through regulation of the SIX6 transcription factor | solute carrier family 38, member 6; Probable sodium-dependent amino acid/proton antiporter | 0.472 |
| DPYD | ACLY | ENSP00000359211 | ENSP00000253792 | dihydropyrimidine dehydrogenase | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | 0.940 |
| DPYD | GMPS | ENSP00000359211 | ENSP00000419851 | dihydropyrimidine dehydrogenase | guanine monphosphate synthetase; Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division | 0.886 |
| DPYD | SLC32A1 | ENSP00000359211 | ENSP00000217420 | dihydropyrimidine dehydrogenase | solute carrier family 32 (GABA vesicular transporter), member 1; Involved in the uptake of GABA and glycine into the synaptic vesicles | 0.557 |
| DPYD | SLC36A1 | ENSP00000359211 | ENSP00000243389 | dihydropyrimidine dehydrogenase | solute carrier family 36 (proton/amino acid symporter), member 1; Neutral amino acid/proton symporter. Has a pH-dependent electrogenic transport activity for small amino acids such as glycine, alanine and proline. Besides small apolar L-amino acids, it also recognize their D-enantiomers and selected amino acid derivatives such as gamma-aminobutyric acid (By similarity) | 0.557 |
| DPYD | SLC36A2 | ENSP00000359211 | ENSP00000334223 | dihydropyrimidine dehydrogenase | solute carrier family 36 (proton/amino acid symporter), member 2; Involved in a pH-dependent electrogenic neuronal transport and sequestration of small amino acids. Transports glycine and proline. Inhibited by sarcosine (By similarity) | 0.557 |
| DPYD | SLC36A3 | ENSP00000359211 | ENSP00000366942 | dihydropyrimidine dehydrogenase | solute carrier family 36 (proton/amino acid symporter), member 3 | 0.557 |
| DPYD | SLC38A6 | ENSP00000359211 | ENSP00000346959 | dihydropyrimidine dehydrogenase | solute carrier family 38, member 6; Probable sodium-dependent amino acid/proton antiporter | 0.557 |
| GMPS | ACLY | ENSP00000419851 | ENSP00000253792 | guanine monphosphate synthetase; Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | 0.414 |
| GMPS | DPYD | ENSP00000419851 | ENSP00000359211 | guanine monphosphate synthetase; Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division | dihydropyrimidine dehydrogenase | 0.886 |
| GMPS | SLC32A1 | ENSP00000419851 | ENSP00000217420 | guanine monphosphate synthetase; Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division | solute carrier family 32 (GABA vesicular transporter), member 1; Involved in the uptake of GABA and glycine into the synaptic vesicles | 0.455 |
| GMPS | SLC36A1 | ENSP00000419851 | ENSP00000243389 | guanine monphosphate synthetase; Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division | solute carrier family 36 (proton/amino acid symporter), member 1; Neutral amino acid/proton symporter. Has a pH-dependent electrogenic transport activity for small amino acids such as glycine, alanine and proline. Besides small apolar L-amino acids, it also recognize their D-enantiomers and selected amino acid derivatives such as gamma-aminobutyric acid (By similarity) | 0.455 |
| GMPS | SLC36A2 | ENSP00000419851 | ENSP00000334223 | guanine monphosphate synthetase; Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division | solute carrier family 36 (proton/amino acid symporter), member 2; Involved in a pH-dependent electrogenic neuronal transport and sequestration of small amino acids. Transports glycine and proline. Inhibited by sarcosine (By similarity) | 0.455 |
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