EGFLAM protein (Homo sapiens) - STRING network view

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EGFLAM

EGF-like, fibronectin type III and laminin G domains (1017 aa)

Predicted Functional Partners:

LGI1

0.689

C2orf88

0.658

DAG1

0.632

FGF22

0.591

NTNG1

0.587

FGF12

0.583

FGF16

0.583

FGF9

0.583

FGF14

0.583

FGF13

0.583

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C2orf88	EGFLAM	ENSP00000345107	ENSP00000346964	chromosome 2 open reading frame 88; Binds to type I regulatory subunits of protein kinase A (PKA-RI) and may anchor/target them to the plasma membrane	EGF-like, fibronectin type III and laminin G domains	0.658
DAG1	EGFLAM	ENSP00000312435	ENSP00000346964	dystroglycan 1 (dystrophin-associated glycoprotein 1); The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization	EGF-like, fibronectin type III and laminin G domains	0.632
DAG1	FGF9	ENSP00000312435	ENSP00000371790	dystroglycan 1 (dystrophin-associated glycoprotein 1); The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization	fibroblast growth factor 9 (glia-activating factor); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors	0.450
EGFLAM	C2orf88	ENSP00000346964	ENSP00000345107	EGF-like, fibronectin type III and laminin G domains	chromosome 2 open reading frame 88; Binds to type I regulatory subunits of protein kinase A (PKA-RI) and may anchor/target them to the plasma membrane	0.658
EGFLAM	DAG1	ENSP00000346964	ENSP00000312435	EGF-like, fibronectin type III and laminin G domains	dystroglycan 1 (dystrophin-associated glycoprotein 1); The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization	0.632
EGFLAM	FGF12	ENSP00000346964	ENSP00000413496	EGF-like, fibronectin type III and laminin G domains	fibroblast growth factor 12; Probably involved in nervous system development and function	0.583
EGFLAM	FGF13	ENSP00000346964	ENSP00000359635	EGF-like, fibronectin type III and laminin G domains	fibroblast growth factor 13; Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules. Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus	0.583
EGFLAM	FGF14	ENSP00000346964	ENSP00000365301	EGF-like, fibronectin type III and laminin G domains	fibroblast growth factor 14; Probably involved in nervous system development and function	0.583
EGFLAM	FGF16	ENSP00000346964	ENSP00000399324	EGF-like, fibronectin type III and laminin G domains	fibroblast growth factor 16	0.583
EGFLAM	FGF22	ENSP00000346964	ENSP00000215530	EGF-like, fibronectin type III and laminin G domains	fibroblast growth factor 22; Plays a role in the fasting response, glucose homeostasis, lipolysis and lipogenesis. Can stimulate cell proliferation (in vitro). May be involved in hair development	0.591
EGFLAM	FGF9	ENSP00000346964	ENSP00000371790	EGF-like, fibronectin type III and laminin G domains	fibroblast growth factor 9 (glia-activating factor); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors	0.583
EGFLAM	LGI1	ENSP00000346964	ENSP00000360472	EGF-like, fibronectin type III and laminin G domains	leucine-rich, glioma inactivated 1; Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors (By similarity). Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway. May play a role in the control of neuroblastoma cell survival	0.689
EGFLAM	NTNG1	ENSP00000346964	ENSP00000359085	EGF-like, fibronectin type III and laminin G domains	netrin G1; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites	0.587
FGF12	EGFLAM	ENSP00000413496	ENSP00000346964	fibroblast growth factor 12; Probably involved in nervous system development and function	EGF-like, fibronectin type III and laminin G domains	0.583
FGF13	EGFLAM	ENSP00000359635	ENSP00000346964	fibroblast growth factor 13; Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules. Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus	EGF-like, fibronectin type III and laminin G domains	0.583
FGF14	EGFLAM	ENSP00000365301	ENSP00000346964	fibroblast growth factor 14; Probably involved in nervous system development and function	EGF-like, fibronectin type III and laminin G domains	0.583
FGF16	EGFLAM	ENSP00000399324	ENSP00000346964	fibroblast growth factor 16	EGF-like, fibronectin type III and laminin G domains	0.583
FGF22	EGFLAM	ENSP00000215530	ENSP00000346964	fibroblast growth factor 22; Plays a role in the fasting response, glucose homeostasis, lipolysis and lipogenesis. Can stimulate cell proliferation (in vitro). May be involved in hair development	EGF-like, fibronectin type III and laminin G domains	0.591
FGF22	FGF9	ENSP00000215530	ENSP00000371790	fibroblast growth factor 22; Plays a role in the fasting response, glucose homeostasis, lipolysis and lipogenesis. Can stimulate cell proliferation (in vitro). May be involved in hair development	fibroblast growth factor 9 (glia-activating factor); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors	0.905
FGF9	DAG1	ENSP00000371790	ENSP00000312435	fibroblast growth factor 9 (glia-activating factor); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors	dystroglycan 1 (dystrophin-associated glycoprotein 1); The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization	0.450

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