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STRINGSTRING
BAZ2B BAZ2B WIPF2 WIPF2 SMARCA5 SMARCA5 BAZ2A BAZ2A WAC WAC RNF20 RNF20 VCP VCP UBC UBC RNF40 RNF40 VCPIP1 VCPIP1 QTRTD1 QTRTD1
"WAC" - WW domain containing adaptor with coiled-coil in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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second shell of interactors
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Known Interactions
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experimentally determined
Predicted Interactions
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Score
WACWW domain containing adaptor with coiled-coil (647 aa)    
Predicted Functional Partners:
VCPIP1
valosin containing protein (p97)/p47 complex interacting protein 1; Acts as a deubiquitinating enzyme. Necessary for VCP- mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP (By similarity) (1222 aa)
         score_image   score_image   0.867
UBC
ubiquitin C (685 aa)
         score_image       0.842
RNF20
ring finger protein 20, E3 ubiquitin protein ligase (975 aa)
         score_image   score_image   0.727
BAZ2B
bromodomain adjacent to zinc finger domain, 2B; May play a role in transcriptional regulation interacting with ISWI (2168 aa)
       score_image     score_image   0.677
BAZ2A
bromodomain adjacent to zinc finger domain, 2A; Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acety [...] (1905 aa)
             score_image   0.663
WIPF2
WAS/WASL interacting protein family, member 2; Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system (440 aa)
             score_image   0.661
RNF40
ring finger protein 40, E3 ubiquitin protein ligase; Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of ’Lys-120’ of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 ’Lys-4’ and ’Lys-79’ methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/ [...] (1001 aa)
         score_image   score_image   0.654
QTRTD1
queuine tRNA-ribosyltransferase domain containing 1; Interacts with QTRT1 to form an active queuine tRNA- ribosyltransferase. This enzyme exchanges queuine for the guanine at the wobble position of tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), thereby forming the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1- yl)amino)methyl)-7-deazaguanosine) (By similarity) (415 aa)
         score_image       0.644
SMARCA5
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5; Helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity. Complexes containing SMARCA5 are capable of forming ordered nucleosome arrays on chromatin; this may require intact histone H4 tails. Also required for replication of pericentric heterochromatin in S-phase specifically in conjunction with BAZ1A. Probably plays a role in repression of polI dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promot [...] (1052 aa)
             score_image   0.610
VCP
valosin containing protein; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the e [...] (806 aa)
         score_image   score_image   0.587
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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