PDE5A protein (Homo sapiens) - STRING network view

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PDE5A

phosphodiesterase 5A, cGMP-specific; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5’- GMP (875 aa)

Predicted Functional Partners:

PRKG1

0.994

ADCY5

0.969

ADCY8

0.969

NPR1

0.969

ADCY6

0.967

ADCY4

0.966

ADCY2

0.965

ADCY7

0.965

NPR2

0.964

ADCY3

0.963

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY2	ADCY3	ENSP00000342952	ENSP00000260600	adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase	adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration	0.912
ADCY2	ADCY4	ENSP00000342952	ENSP00000312126	adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase	adenylate cyclase 4; This is a membrane-bound, calmodulin-insensitive adenylyl cyclase (By similarity)	0.903
ADCY2	ADCY5	ENSP00000342952	ENSP00000419361	adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase	adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase	0.964
ADCY2	ADCY6	ENSP00000342952	ENSP00000311405	adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase	adenylate cyclase 6; Membrane-bound, calcium-inhibitable adenylyl cyclase (By similarity)	0.920
ADCY2	ADCY7	ENSP00000342952	ENSP00000254235	adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase	adenylate cyclase 7; This is a membrane-bound, calcium-inhibitable adenylyl cyclase	0.903
ADCY2	ADCY8	ENSP00000342952	ENSP00000286355	adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase	adenylate cyclase 8 (brain); This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence (By similarity)	0.917
ADCY2	PDE5A	ENSP00000342952	ENSP00000347046	adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase	phosphodiesterase 5A, cGMP-specific; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5’- GMP	0.965
ADCY2	PRKG1	ENSP00000342952	ENSP00000363092	adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase	protein kinase, cGMP-dependent, type I; Serine/threonine protein kinase that acts as key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of t [...]	0.557
ADCY3	ADCY2	ENSP00000260600	ENSP00000342952	adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration	adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase	0.912
ADCY3	ADCY4	ENSP00000260600	ENSP00000312126	adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration	adenylate cyclase 4; This is a membrane-bound, calmodulin-insensitive adenylyl cyclase (By similarity)	0.926
ADCY3	ADCY5	ENSP00000260600	ENSP00000419361	adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration	adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase	0.911
ADCY3	ADCY6	ENSP00000260600	ENSP00000311405	adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration	adenylate cyclase 6; Membrane-bound, calcium-inhibitable adenylyl cyclase (By similarity)	0.911
ADCY3	ADCY7	ENSP00000260600	ENSP00000254235	adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration	adenylate cyclase 7; This is a membrane-bound, calcium-inhibitable adenylyl cyclase	0.911
ADCY3	ADCY8	ENSP00000260600	ENSP00000286355	adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration	adenylate cyclase 8 (brain); This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence (By similarity)	0.909
ADCY3	PDE5A	ENSP00000260600	ENSP00000347046	adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration	phosphodiesterase 5A, cGMP-specific; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5’- GMP	0.963
ADCY3	PRKG1	ENSP00000260600	ENSP00000363092	adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration	protein kinase, cGMP-dependent, type I; Serine/threonine protein kinase that acts as key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of t [...]	0.907
ADCY4	ADCY2	ENSP00000312126	ENSP00000342952	adenylate cyclase 4; This is a membrane-bound, calmodulin-insensitive adenylyl cyclase (By similarity)	adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase	0.903
ADCY4	ADCY3	ENSP00000312126	ENSP00000260600	adenylate cyclase 4; This is a membrane-bound, calmodulin-insensitive adenylyl cyclase (By similarity)	adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration	0.926
ADCY4	ADCY5	ENSP00000312126	ENSP00000419361	adenylate cyclase 4; This is a membrane-bound, calmodulin-insensitive adenylyl cyclase (By similarity)	adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase	0.921
ADCY4	ADCY6	ENSP00000312126	ENSP00000311405	adenylate cyclase 4; This is a membrane-bound, calmodulin-insensitive adenylyl cyclase (By similarity)	adenylate cyclase 6; Membrane-bound, calcium-inhibitable adenylyl cyclase (By similarity)	0.921

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