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TNNT3 TNNT3 TPM3 TPM3 MYH6 MYH6 TPM2 TPM2 TNNT2 TNNT2 MYH8 MYH8 TNNI2 TNNI2 MYH3 MYH3 MYL4 MYL4 TNNI3 TNNI3 TNNI1 TNNI1
"MYL4" - myosin, light chain 4, alkali in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
MYL4myosin, light chain 4, alkali; atrial, embryonic; Regulatory light chain of myosin. Does not bind calcium (197 aa)    
Predicted Functional Partners:
TNNI1
troponin I type 1 (skeletal, slow) (187 aa)
      score_image score_image score_image score_image   0.965
MYH6
myosin, heavy chain 6, cardiac muscle, alpha; Muscle contraction (1939 aa)
      score_image score_image score_image score_image   0.956
MYH3
myosin, heavy chain 3, skeletal muscle, embryonic; Muscle contraction (1940 aa)
      score_image score_image score_image score_image   0.956
MYH8
myosin, heavy chain 8, skeletal muscle, perinatal; Muscle contraction (1937 aa)
      score_image score_image score_image score_image   0.952
TNNT2
troponin T type 2 (cardiac); Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity (288 aa)
      score_image score_image score_image score_image   0.951
TNNI2
troponin I type 2 (skeletal, fast); Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity (182 aa)
      score_image score_image score_image score_image   0.947
TNNT3
troponin T type 3 (skeletal, fast) (258 aa)
      score_image score_image score_image score_image   0.946
TPM2
tropomyosin 2 (beta); Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization (By similarity) (284 aa)
      score_image score_image score_image score_image   0.944
TNNI3
troponin I type 3 (cardiac); Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity (210 aa)
      score_image score_image score_image score_image   0.942
TPM3
tropomyosin 3; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments (285 aa)
      score_image score_image score_image score_image   0.935
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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