MRPL52 protein (Homo sapiens) - STRING network view

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MRPL52

mitochondrial ribosomal protein L52 (123 aa)

Predicted Functional Partners:

MRPL51

0.982

MRPL55

0.974

CUL7

0.974

MRPL23

0.961

MRPL3

0.948

MRPL32

0.944

MRPL13

0.938

MRPL39

0.918

MRPL49

0.915

ICT1

0.910

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CUL7	MRPL13	ENSP00000438788	ENSP00000306548	cullin 7; Component of a probable SCF-like E3 ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably plays a role in the degradation of proteins involved in endothelial proliferation and/or differentiation (By similarity). Seems not to promote polyubiquitination and proteasomal degradation of TP53. In vitro, complexes of CUL7 with either CUL9 or FBXW8 or TP53 contain E3 ubiquitin-protein ligase activity. In complex with FBXW8, mediates ubiquitination and consequent degradation of GORASP1, acting as a compo [...]	mitochondrial ribosomal protein L13	0.902
CUL7	MRPL52	ENSP00000438788	ENSP00000347277	cullin 7; Component of a probable SCF-like E3 ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably plays a role in the degradation of proteins involved in endothelial proliferation and/or differentiation (By similarity). Seems not to promote polyubiquitination and proteasomal degradation of TP53. In vitro, complexes of CUL7 with either CUL9 or FBXW8 or TP53 contain E3 ubiquitin-protein ligase activity. In complex with FBXW8, mediates ubiquitination and consequent degradation of GORASP1, acting as a compo [...]	mitochondrial ribosomal protein L52	0.974
ICT1	MRPL13	ENSP00000301585	ENSP00000306548	immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	mitochondrial ribosomal protein L13	0.903
ICT1	MRPL23	ENSP00000301585	ENSP00000370930	immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	mitochondrial ribosomal protein L23	0.951
ICT1	MRPL3	ENSP00000301585	ENSP00000264995	immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	mitochondrial ribosomal protein L3	0.986
ICT1	MRPL32	ENSP00000301585	ENSP00000223324	immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	mitochondrial ribosomal protein L32	0.480
ICT1	MRPL39	ENSP00000301585	ENSP00000305682	immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	mitochondrial ribosomal protein L39	0.799
ICT1	MRPL51	ENSP00000301585	ENSP00000229238	immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	mitochondrial ribosomal protein L51	0.934
ICT1	MRPL52	ENSP00000301585	ENSP00000347277	immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	mitochondrial ribosomal protein L52	0.910
ICT1	MRPL55	ENSP00000301585	ENSP00000355692	immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	mitochondrial ribosomal protein L55	0.938
MRPL13	CUL7	ENSP00000306548	ENSP00000438788	mitochondrial ribosomal protein L13	cullin 7; Component of a probable SCF-like E3 ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably plays a role in the degradation of proteins involved in endothelial proliferation and/or differentiation (By similarity). Seems not to promote polyubiquitination and proteasomal degradation of TP53. In vitro, complexes of CUL7 with either CUL9 or FBXW8 or TP53 contain E3 ubiquitin-protein ligase activity. In complex with FBXW8, mediates ubiquitination and consequent degradation of GORASP1, acting as a compo [...]	0.902
MRPL13	ICT1	ENSP00000306548	ENSP00000301585	mitochondrial ribosomal protein L13	immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	0.903
MRPL13	MRPL23	ENSP00000306548	ENSP00000370930	mitochondrial ribosomal protein L13	mitochondrial ribosomal protein L23	0.979
MRPL13	MRPL3	ENSP00000306548	ENSP00000264995	mitochondrial ribosomal protein L13	mitochondrial ribosomal protein L3	0.999
MRPL13	MRPL32	ENSP00000306548	ENSP00000223324	mitochondrial ribosomal protein L13	mitochondrial ribosomal protein L32	0.931
MRPL13	MRPL39	ENSP00000306548	ENSP00000305682	mitochondrial ribosomal protein L13	mitochondrial ribosomal protein L39	0.941
MRPL13	MRPL49	ENSP00000306548	ENSP00000279242	mitochondrial ribosomal protein L13	mitochondrial ribosomal protein L49	0.901
MRPL13	MRPL52	ENSP00000306548	ENSP00000347277	mitochondrial ribosomal protein L13	mitochondrial ribosomal protein L52	0.938
MRPL13	MRPL55	ENSP00000306548	ENSP00000355692	mitochondrial ribosomal protein L13	mitochondrial ribosomal protein L55	0.938
MRPL23	ICT1	ENSP00000370930	ENSP00000301585	mitochondrial ribosomal protein L23	immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes	0.951

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