node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BEGAIN | CEP170 | ENSP00000347301 | ENSP00000355500 | brain-enriched guanylate kinase-associated homolog (rat); May sustain the structure of the postsynaptic density (PSD) | centrosomal protein 170kDa; Plays a role in microtubule organization | 0.971 |
BEGAIN | DLG1 | ENSP00000347301 | ENSP00000345731 | brain-enriched guanylate kinase-associated homolog (rat); May sustain the structure of the postsynaptic density (PSD) | discs, large homolog 1 (Drosophila) | 0.675 |
BEGAIN | DLG2 | ENSP00000347301 | ENSP00000365272 | brain-enriched guanylate kinase-associated homolog (rat); May sustain the structure of the postsynaptic density (PSD) | discs, large homolog 2 (Drosophila); Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity) | 0.756 |
BEGAIN | DLG4 | ENSP00000347301 | ENSP00000293813 | brain-enriched guanylate kinase-associated homolog (rat); May sustain the structure of the postsynaptic density (PSD) | discs, large homolog 4 (Drosophila); Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity) | 0.730 |
BEGAIN | DLK1 | ENSP00000347301 | ENSP00000340292 | brain-enriched guanylate kinase-associated homolog (rat); May sustain the structure of the postsynaptic density (PSD) | delta-like 1 homolog (Drosophila); May have a role in neuroendocrine differentiation | 0.439 |
BEGAIN | F11R | ENSP00000347301 | ENSP00000289779 | brain-enriched guanylate kinase-associated homolog (rat); May sustain the structure of the postsynaptic density (PSD) | F11 receptor; Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus | 0.459 |
BEGAIN | MPP2 | ENSP00000347301 | ENSP00000269095 | brain-enriched guanylate kinase-associated homolog (rat); May sustain the structure of the postsynaptic density (PSD) | membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) | 0.814 |
BEGAIN | RTL1 | ENSP00000347301 | ENSP00000435342 | brain-enriched guanylate kinase-associated homolog (rat); May sustain the structure of the postsynaptic density (PSD) | retrotransposon-like 1; Plays an essential role in capillaries endothelial cells for the maintenance of feto-maternal interface and for development of the placenta (By similarity) | 0.619 |
BEGAIN | ZNF774 | ENSP00000347301 | ENSP00000346348 | brain-enriched guanylate kinase-associated homolog (rat); May sustain the structure of the postsynaptic density (PSD) | zinc finger protein 774; May be involved in transcriptional regulation (By similarity) | 0.603 |
CEP170 | BEGAIN | ENSP00000355500 | ENSP00000347301 | centrosomal protein 170kDa; Plays a role in microtubule organization | brain-enriched guanylate kinase-associated homolog (rat); May sustain the structure of the postsynaptic density (PSD) | 0.971 |
DLG1 | BEGAIN | ENSP00000345731 | ENSP00000347301 | discs, large homolog 1 (Drosophila) | brain-enriched guanylate kinase-associated homolog (rat); May sustain the structure of the postsynaptic density (PSD) | 0.675 |
DLG1 | DLG2 | ENSP00000345731 | ENSP00000365272 | discs, large homolog 1 (Drosophila) | discs, large homolog 2 (Drosophila); Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity) | 0.574 |
DLG1 | DLG4 | ENSP00000345731 | ENSP00000293813 | discs, large homolog 1 (Drosophila) | discs, large homolog 4 (Drosophila); Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity) | 0.956 |
DLG1 | DLK1 | ENSP00000345731 | ENSP00000340292 | discs, large homolog 1 (Drosophila) | delta-like 1 homolog (Drosophila); May have a role in neuroendocrine differentiation | 0.839 |
DLG1 | MPP2 | ENSP00000345731 | ENSP00000269095 | discs, large homolog 1 (Drosophila) | membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) | 0.687 |
DLG2 | BEGAIN | ENSP00000365272 | ENSP00000347301 | discs, large homolog 2 (Drosophila); Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity) | brain-enriched guanylate kinase-associated homolog (rat); May sustain the structure of the postsynaptic density (PSD) | 0.756 |
DLG2 | DLG1 | ENSP00000365272 | ENSP00000345731 | discs, large homolog 2 (Drosophila); Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity) | discs, large homolog 1 (Drosophila) | 0.574 |
DLG2 | DLG4 | ENSP00000365272 | ENSP00000293813 | discs, large homolog 2 (Drosophila); Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity) | discs, large homolog 4 (Drosophila); Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity) | 0.585 |
DLG2 | F11R | ENSP00000365272 | ENSP00000289779 | discs, large homolog 2 (Drosophila); Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity) | F11 receptor; Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus | 0.563 |
DLG4 | BEGAIN | ENSP00000293813 | ENSP00000347301 | discs, large homolog 4 (Drosophila); Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity) | brain-enriched guanylate kinase-associated homolog (rat); May sustain the structure of the postsynaptic density (PSD) | 0.730 |