| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EPS15 | ITCH | ENSP00000360798 | ENSP00000363998 | epidermal growth factor receptor pathway substrate 15; Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta- 1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seem [...] | itchy E3 ubiquitin protein ligase | 0.662 |
| EPS15 | SPG20 | ENSP00000360798 | ENSP00000347314 | epidermal growth factor receptor pathway substrate 15; Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta- 1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seem [...] | spastic paraplegia 20 (Troyer syndrome); May be implicated in endosomal trafficking, or microtubule dynamics, or both | 0.953 |
| EPS15 | UBC | ENSP00000360798 | ENSP00000344818 | epidermal growth factor receptor pathway substrate 15; Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta- 1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seem [...] | ubiquitin C | 0.999 |
| EPS15 | UEVLD | ENSP00000360798 | ENSP00000379500 | epidermal growth factor receptor pathway substrate 15; Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta- 1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seem [...] | UEV and lactate/malate dehyrogenase domains; Possible negative regulator of polyubiquitination | 0.491 |
| EPS15 | WWP1 | ENSP00000360798 | ENSP00000265428 | epidermal growth factor receptor pathway substrate 15; Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta- 1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seem [...] | WW domain containing E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in resp [...] | 0.621 |
| HSPA9 | SPG20 | ENSP00000297185 | ENSP00000347314 | heat shock 70kDa protein 9 (mortalin) | spastic paraplegia 20 (Troyer syndrome); May be implicated in endosomal trafficking, or microtubule dynamics, or both | 0.907 |
| HSPA9 | UBC | ENSP00000297185 | ENSP00000344818 | heat shock 70kDa protein 9 (mortalin) | ubiquitin C | 0.997 |
| ITCH | EPS15 | ENSP00000363998 | ENSP00000360798 | itchy E3 ubiquitin protein ligase | epidermal growth factor receptor pathway substrate 15; Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta- 1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seem [...] | 0.662 |
| ITCH | SPG20 | ENSP00000363998 | ENSP00000347314 | itchy E3 ubiquitin protein ligase | spastic paraplegia 20 (Troyer syndrome); May be implicated in endosomal trafficking, or microtubule dynamics, or both | 0.975 |
| ITCH | UBC | ENSP00000363998 | ENSP00000344818 | itchy E3 ubiquitin protein ligase | ubiquitin C | 0.999 |
| ITCH | WWP1 | ENSP00000363998 | ENSP00000265428 | itchy E3 ubiquitin protein ligase | WW domain containing E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in resp [...] | 0.901 |
| PLIN3 | SPG20 | ENSP00000221957 | ENSP00000347314 | perilipin 3; Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network | spastic paraplegia 20 (Troyer syndrome); May be implicated in endosomal trafficking, or microtubule dynamics, or both | 0.820 |
| PLIN3 | UBC | ENSP00000221957 | ENSP00000344818 | perilipin 3; Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network | ubiquitin C | 0.914 |
| SORBS1 | SPG20 | ENSP00000355136 | ENSP00000347314 | sorbin and SH3 domain containing 1 | spastic paraplegia 20 (Troyer syndrome); May be implicated in endosomal trafficking, or microtubule dynamics, or both | 0.811 |
| SORBS1 | TRIM45 | ENSP00000355136 | ENSP00000256649 | sorbin and SH3 domain containing 1 | tripartite motif containing 45; May act as a transcriptional repressor in mitogen- activated protein kinase signaling pathway | 0.817 |
| SORBS1 | UEVLD | ENSP00000355136 | ENSP00000379500 | sorbin and SH3 domain containing 1 | UEV and lactate/malate dehyrogenase domains; Possible negative regulator of polyubiquitination | 0.812 |
| SPG20 | EPS15 | ENSP00000347314 | ENSP00000360798 | spastic paraplegia 20 (Troyer syndrome); May be implicated in endosomal trafficking, or microtubule dynamics, or both | epidermal growth factor receptor pathway substrate 15; Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta- 1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seem [...] | 0.953 |
| SPG20 | HSPA9 | ENSP00000347314 | ENSP00000297185 | spastic paraplegia 20 (Troyer syndrome); May be implicated in endosomal trafficking, or microtubule dynamics, or both | heat shock 70kDa protein 9 (mortalin) | 0.907 |
| SPG20 | ITCH | ENSP00000347314 | ENSP00000363998 | spastic paraplegia 20 (Troyer syndrome); May be implicated in endosomal trafficking, or microtubule dynamics, or both | itchy E3 ubiquitin protein ligase | 0.975 |
| SPG20 | PLIN3 | ENSP00000347314 | ENSP00000221957 | spastic paraplegia 20 (Troyer syndrome); May be implicated in endosomal trafficking, or microtubule dynamics, or both | perilipin 3; Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network | 0.820 |
Share
