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TXNRD3 TXNRD3 SELT SELT MLEC MLEC TXNRD1 TXNRD1 CNOT1 CNOT1 MSRB3 MSRB3 ERGIC1 ERGIC1 PRDM4 PRDM4 BACE1 BACE1 LEMD3 LEMD3 MSRA MSRA
"MSRB3" - methionine sulfoxide reductase B3 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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second shell of interactors
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Known Interactions
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experimentally determined
Predicted Interactions
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fusion edge
gene fusions
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gene co-occurrence
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textmining
coexpression edge
co-expression
homology edge
protein homology
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Score
MSRB3methionine sulfoxide reductase B3; Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing (192 aa)    
Predicted Functional Partners:
MSRA
methionine sulfoxide reductase A; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (235 aa)
score_image score_image score_image score_image score_image   score_image   0.957
LEMD3
LEM domain containing 3; Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest (911 aa)
            score_image   0.669
MLEC
malectin; Carbohydrate-binding protein with a strong ligand preference for Glc2-N-glycan. May play a role in the early steps of protein N-glycosylation (By similarity) (292 aa)
            score_image   0.611
TXNRD1
thioredoxin reductase 1 (649 aa)
      score_image     score_image   0.602
TXNRD3
thioredoxin reductase 3; Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components (By similarity) (698 aa)
      score_image     score_image   0.602
CNOT1
CCR4-NOT transcription complex, subunit 1 (2376 aa)
            score_image   0.580
ERGIC1
endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1; Possible role in transport between endoplasmic reticulum and Golgi (290 aa)
            score_image   0.573
PRDM4
PR domain containing 4; May function as a transcription factor involved in cell differentiation (By similarity) (801 aa)
        score_image       0.571
BACE1
beta-site APP-cleaving enzyme 1; Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase (501 aa)
            score_image   0.562
SELT
selenoprotein T precursor (195 aa)
            score_image   0.552
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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