node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BACE1 | MSRB3 | ENSP00000318585 | ENSP00000347324 | beta-site APP-cleaving enzyme 1; Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase | methionine sulfoxide reductase B3; Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing | 0.562 |
CNOT1 | MSRB3 | ENSP00000320949 | ENSP00000347324 | CCR4-NOT transcription complex, subunit 1 | methionine sulfoxide reductase B3; Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing | 0.580 |
ERGIC1 | MSRB3 | ENSP00000377374 | ENSP00000347324 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1; Possible role in transport between endoplasmic reticulum and Golgi | methionine sulfoxide reductase B3; Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing | 0.573 |
LEMD3 | MSRB3 | ENSP00000308369 | ENSP00000347324 | LEM domain containing 3; Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest | methionine sulfoxide reductase B3; Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing | 0.669 |
MLEC | MSRB3 | ENSP00000228506 | ENSP00000347324 | malectin; Carbohydrate-binding protein with a strong ligand preference for Glc2-N-glycan. May play a role in the early steps of protein N-glycosylation (By similarity) | methionine sulfoxide reductase B3; Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing | 0.611 |
MSRA | MSRB3 | ENSP00000313921 | ENSP00000347324 | methionine sulfoxide reductase A; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine | methionine sulfoxide reductase B3; Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing | 0.957 |
MSRB3 | BACE1 | ENSP00000347324 | ENSP00000318585 | methionine sulfoxide reductase B3; Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing | beta-site APP-cleaving enzyme 1; Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase | 0.562 |
MSRB3 | CNOT1 | ENSP00000347324 | ENSP00000320949 | methionine sulfoxide reductase B3; Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing | CCR4-NOT transcription complex, subunit 1 | 0.580 |
MSRB3 | ERGIC1 | ENSP00000347324 | ENSP00000377374 | methionine sulfoxide reductase B3; Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1; Possible role in transport between endoplasmic reticulum and Golgi | 0.573 |
MSRB3 | LEMD3 | ENSP00000347324 | ENSP00000308369 | methionine sulfoxide reductase B3; Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing | LEM domain containing 3; Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest | 0.669 |
MSRB3 | MLEC | ENSP00000347324 | ENSP00000228506 | methionine sulfoxide reductase B3; Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing | malectin; Carbohydrate-binding protein with a strong ligand preference for Glc2-N-glycan. May play a role in the early steps of protein N-glycosylation (By similarity) | 0.611 |
MSRB3 | MSRA | ENSP00000347324 | ENSP00000313921 | methionine sulfoxide reductase B3; Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing | methionine sulfoxide reductase A; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine | 0.957 |
MSRB3 | PRDM4 | ENSP00000347324 | ENSP00000228437 | methionine sulfoxide reductase B3; Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing | PR domain containing 4; May function as a transcription factor involved in cell differentiation (By similarity) | 0.571 |
MSRB3 | SELT | ENSP00000347324 | ENSP00000418910 | methionine sulfoxide reductase B3; Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing | selenoprotein T precursor | 0.552 |
MSRB3 | TXNRD1 | ENSP00000347324 | ENSP00000434516 | methionine sulfoxide reductase B3; Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing | thioredoxin reductase 1 | 0.602 |
MSRB3 | TXNRD3 | ENSP00000347324 | ENSP00000430031 | methionine sulfoxide reductase B3; Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing | thioredoxin reductase 3; Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components (By similarity) | 0.602 |
PRDM4 | MSRB3 | ENSP00000228437 | ENSP00000347324 | PR domain containing 4; May function as a transcription factor involved in cell differentiation (By similarity) | methionine sulfoxide reductase B3; Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing | 0.571 |
SELT | MSRB3 | ENSP00000418910 | ENSP00000347324 | selenoprotein T precursor | methionine sulfoxide reductase B3; Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing | 0.552 |
SELT | TXNRD1 | ENSP00000418910 | ENSP00000434516 | selenoprotein T precursor | thioredoxin reductase 1 | 0.499 |
SELT | TXNRD3 | ENSP00000418910 | ENSP00000430031 | selenoprotein T precursor | thioredoxin reductase 3; Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components (By similarity) | 0.574 |