KEL protein (Homo sapiens) - STRING network view

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KEL

Kell blood group, metallo-endopeptidase; Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3 (732 aa)

Predicted Functional Partners:

EDN3

0.826

XKRX

0.810

XKR3

0.810

PIP

0.757

EDN2

0.713

EDN1

0.690

DCLK3

0.581

ITGA2

0.581

XK

0.566

RHCE

0.556

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DCLK3	KEL	ENSP00000394484	ENSP00000347409	doublecortin-like kinase 3	Kell blood group, metallo-endopeptidase; Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3	0.581
EDN1	EDN2	ENSP00000368683	ENSP00000361668	endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides	endothelin 2; Endothelins are endothelium-derived vasoconstrictor peptides	0.916
EDN1	EDN3	ENSP00000368683	ENSP00000337128	endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides	endothelin 3; Endothelins are endothelium-derived vasoconstrictor peptides	0.923
EDN1	ITGA2	ENSP00000368683	ENSP00000296585	endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix	0.806
EDN1	KEL	ENSP00000368683	ENSP00000347409	endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides	Kell blood group, metallo-endopeptidase; Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3	0.690
EDN2	EDN1	ENSP00000361668	ENSP00000368683	endothelin 2; Endothelins are endothelium-derived vasoconstrictor peptides	endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides	0.916
EDN2	EDN3	ENSP00000361668	ENSP00000337128	endothelin 2; Endothelins are endothelium-derived vasoconstrictor peptides	endothelin 3; Endothelins are endothelium-derived vasoconstrictor peptides	0.919
EDN2	KEL	ENSP00000361668	ENSP00000347409	endothelin 2; Endothelins are endothelium-derived vasoconstrictor peptides	Kell blood group, metallo-endopeptidase; Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3	0.713
EDN3	EDN1	ENSP00000337128	ENSP00000368683	endothelin 3; Endothelins are endothelium-derived vasoconstrictor peptides	endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides	0.923
EDN3	EDN2	ENSP00000337128	ENSP00000361668	endothelin 3; Endothelins are endothelium-derived vasoconstrictor peptides	endothelin 2; Endothelins are endothelium-derived vasoconstrictor peptides	0.919
EDN3	ITGA2	ENSP00000337128	ENSP00000296585	endothelin 3; Endothelins are endothelium-derived vasoconstrictor peptides	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix	0.472
EDN3	KEL	ENSP00000337128	ENSP00000347409	endothelin 3; Endothelins are endothelium-derived vasoconstrictor peptides	Kell blood group, metallo-endopeptidase; Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3	0.826
EDN3	PIP	ENSP00000337128	ENSP00000291009	endothelin 3; Endothelins are endothelium-derived vasoconstrictor peptides	prolactin-induced protein	0.604
ITGA2	EDN1	ENSP00000296585	ENSP00000368683	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix	endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides	0.806
ITGA2	EDN3	ENSP00000296585	ENSP00000337128	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix	endothelin 3; Endothelins are endothelium-derived vasoconstrictor peptides	0.472
ITGA2	KEL	ENSP00000296585	ENSP00000347409	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix	Kell blood group, metallo-endopeptidase; Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3	0.581
ITGA2	RHCE	ENSP00000296585	ENSP00000294413	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix	Rh blood group, CcEe antigens	0.501
KEL	DCLK3	ENSP00000347409	ENSP00000394484	Kell blood group, metallo-endopeptidase; Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3	doublecortin-like kinase 3	0.581
KEL	EDN1	ENSP00000347409	ENSP00000368683	Kell blood group, metallo-endopeptidase; Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3	endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides	0.690
KEL	EDN2	ENSP00000347409	ENSP00000361668	Kell blood group, metallo-endopeptidase; Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3	endothelin 2; Endothelins are endothelium-derived vasoconstrictor peptides	0.713

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