node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANO1 | BEST1 | ENSP00000347454 | ENSP00000399709 | anoctamin 1, calcium activated chloride channel; Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development | bestrophin 1; Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate | 0.789 |
ANO1 | BEST2 | ENSP00000347454 | ENSP00000042931 | anoctamin 1, calcium activated chloride channel; Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development | bestrophin 2; Forms calcium-sensitive chloride channels. Permeable to bicarbonate | 0.823 |
ANO1 | BEST3 | ENSP00000347454 | ENSP00000332413 | anoctamin 1, calcium activated chloride channel; Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development | bestrophin 3; Forms calcium-sensitive (By similarity) chloride channels. Permeable to bicarbonate (By similarity) | 0.779 |
ANO1 | CFTR | ENSP00000347454 | ENSP00000003084 | anoctamin 1, calcium activated chloride channel; Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development | cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7); Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1 | 0.979 |
ANO1 | ITPR1 | ENSP00000347454 | ENSP00000306253 | anoctamin 1, calcium activated chloride channel; Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development | inositol 1,4,5-trisphosphate receptor, type 1; Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity) | 0.824 |
ANO1 | KIDINS220 | ENSP00000347454 | ENSP00000256707 | anoctamin 1, calcium activated chloride channel; Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development | kinase D-interacting substrate, 220kDa; Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. May play a role in neurotrophin- and ephrin- mediated neuronal outgrowth and in axon guidance during ne [...] | 0.659 |
ANO1 | PDGFRA | ENSP00000347454 | ENSP00000257290 | anoctamin 1, calcium activated chloride channel; Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development | platelet-derived growth factor receptor, alpha polypeptide; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining th [...] | 0.705 |
ANO1 | RTEL1 | ENSP00000347454 | ENSP00000359035 | anoctamin 1, calcium activated chloride channel; Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development | regulator of telomere elongation helicase 1 | 0.757 |
ANO1 | SLC26A6 | ENSP00000347454 | ENSP00000378920 | anoctamin 1, calcium activated chloride channel; Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development | solute carrier family 26, member 6; Does not seem to be involved in anion transport | 0.678 |
ANO1 | TTYH3 | ENSP00000347454 | ENSP00000258796 | anoctamin 1, calcium activated chloride channel; Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development | tweety homolog 3 (Drosophila); Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction | 0.734 |
BEST1 | ANO1 | ENSP00000399709 | ENSP00000347454 | bestrophin 1; Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate | anoctamin 1, calcium activated chloride channel; Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development | 0.789 |
BEST1 | BEST2 | ENSP00000399709 | ENSP00000042931 | bestrophin 1; Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate | bestrophin 2; Forms calcium-sensitive chloride channels. Permeable to bicarbonate | 0.565 |
BEST1 | BEST3 | ENSP00000399709 | ENSP00000332413 | bestrophin 1; Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate | bestrophin 3; Forms calcium-sensitive (By similarity) chloride channels. Permeable to bicarbonate (By similarity) | 0.576 |
BEST1 | CFTR | ENSP00000399709 | ENSP00000003084 | bestrophin 1; Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate | cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7); Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1 | 0.647 |
BEST1 | SLC26A6 | ENSP00000399709 | ENSP00000378920 | bestrophin 1; Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate | solute carrier family 26, member 6; Does not seem to be involved in anion transport | 0.545 |
BEST1 | TTYH3 | ENSP00000399709 | ENSP00000258796 | bestrophin 1; Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate | tweety homolog 3 (Drosophila); Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction | 0.728 |
BEST2 | ANO1 | ENSP00000042931 | ENSP00000347454 | bestrophin 2; Forms calcium-sensitive chloride channels. Permeable to bicarbonate | anoctamin 1, calcium activated chloride channel; Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development | 0.823 |
BEST2 | BEST1 | ENSP00000042931 | ENSP00000399709 | bestrophin 2; Forms calcium-sensitive chloride channels. Permeable to bicarbonate | bestrophin 1; Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate | 0.565 |
BEST2 | BEST3 | ENSP00000042931 | ENSP00000332413 | bestrophin 2; Forms calcium-sensitive chloride channels. Permeable to bicarbonate | bestrophin 3; Forms calcium-sensitive (By similarity) chloride channels. Permeable to bicarbonate (By similarity) | 0.559 |
BEST2 | CFTR | ENSP00000042931 | ENSP00000003084 | bestrophin 2; Forms calcium-sensitive chloride channels. Permeable to bicarbonate | cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7); Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1 | 0.678 |