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RTEL1 RTEL1 ITPR1 ITPR1 PDGFRA PDGFRA ANO1 ANO1 TTYH3 TTYH3 SLC26A6 SLC26A6 BEST1 BEST1 KIDINS220 KIDINS220 CFTR CFTR BEST2 BEST2 BEST3 BEST3
"ANO1" - anoctamin 1, calcium activated chloride channel in Homo sapiens
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protein of unknown 3D structure
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Predicted Interactions
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ANO1anoctamin 1, calcium activated chloride channel; Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development (986 aa)    
Predicted Functional Partners:
CFTR
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7); Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1 (1480 aa)
        score_image score_image score_image   0.979
ITPR1
inositol 1,4,5-trisphosphate receptor, type 1; Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity) (2743 aa)
            score_image   0.824
BEST2
bestrophin 2; Forms calcium-sensitive chloride channels. Permeable to bicarbonate (509 aa)
          score_image score_image   0.823
BEST1
bestrophin 1; Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate (604 aa)
          score_image score_image   0.789
BEST3
bestrophin 3; Forms calcium-sensitive (By similarity) chloride channels. Permeable to bicarbonate (By similarity) (668 aa)
          score_image score_image   0.779
RTEL1
regulator of telomere elongation helicase 1 (1219 aa)
            score_image   0.757
TTYH3
tweety homolog 3 (Drosophila); Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction (523 aa)
          score_image score_image   0.734
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining th [...] (1089 aa)
            score_image   0.705
SLC26A6
solute carrier family 26, member 6; Does not seem to be involved in anion transport (759 aa)
          score_image score_image   0.678
KIDINS220
kinase D-interacting substrate, 220kDa; Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. May play a role in neurotrophin- and ephrin- mediated neuronal outgrowth and in axon guidance during ne [...] (1771 aa)
            score_image   0.659
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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