| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCM2 | ITGB1 | ENSP00000370503 | ENSP00000303351 | cerebral cavernous malformation 2; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3- dependent p38 activation induced by hyperosmotic shock (By similarity) | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.440 |
| CCM2 | ITGB1BP1 | ENSP00000370503 | ENSP00000347504 | cerebral cavernous malformation 2; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3- dependent p38 activation induced by hyperosmotic shock (By similarity) | integrin beta 1 binding protein 1; Regulates integrin signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha- 5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. May play a role in the recruitment of ITGB1 to focal contacts during integrin-dependent cell adhesion | 0.748 |
| CCM2 | KRIT1 | ENSP00000370503 | ENSP00000344668 | cerebral cavernous malformation 2; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3- dependent p38 activation induced by hyperosmotic shock (By similarity) | KRIT1, ankyrin repeat containing | 0.990 |
| CCM2 | MYL9 | ENSP00000370503 | ENSP00000279022 | cerebral cavernous malformation 2; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3- dependent p38 activation induced by hyperosmotic shock (By similarity) | myosin, light chain 9, regulatory; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion | 0.680 |
| CCM2 | PDCD10 | ENSP00000370503 | ENSP00000376506 | cerebral cavernous malformation 2; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3- dependent p38 activation induced by hyperosmotic shock (By similarity) | programmed cell death 10; Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and MST4 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity) | 0.994 |
| CCM2 | PDHX | ENSP00000370503 | ENSP00000227868 | cerebral cavernous malformation 2; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3- dependent p38 activation induced by hyperosmotic shock (By similarity) | pyruvate dehydrogenase complex, component X; Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex | 0.418 |
| CCM2 | RAP1A | ENSP00000370503 | ENSP00000348786 | cerebral cavernous malformation 2; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3- dependent p38 activation induced by hyperosmotic shock (By similarity) | RAP1A, member of RAS oncogene family; Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner | 0.499 |
| CCM2 | RAP1B | ENSP00000370503 | ENSP00000250559 | cerebral cavernous malformation 2; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3- dependent p38 activation induced by hyperosmotic shock (By similarity) | RAP1B, member of RAS oncogene family | 0.499 |
| ITGB1 | CCM2 | ENSP00000303351 | ENSP00000370503 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | cerebral cavernous malformation 2; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3- dependent p38 activation induced by hyperosmotic shock (By similarity) | 0.440 |
| ITGB1 | ITGB1BP1 | ENSP00000303351 | ENSP00000347504 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | integrin beta 1 binding protein 1; Regulates integrin signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha- 5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. May play a role in the recruitment of ITGB1 to focal contacts during integrin-dependent cell adhesion | 0.992 |
| ITGB1 | KRIT1 | ENSP00000303351 | ENSP00000344668 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | KRIT1, ankyrin repeat containing | 0.493 |
| ITGB1 | MYL9 | ENSP00000303351 | ENSP00000279022 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | myosin, light chain 9, regulatory; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion | 0.457 |
| ITGB1 | PDCD10 | ENSP00000303351 | ENSP00000376506 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | programmed cell death 10; Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and MST4 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity) | 0.515 |
| ITGB1 | PDHX | ENSP00000303351 | ENSP00000227868 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | pyruvate dehydrogenase complex, component X; Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex | 0.438 |
| ITGB1 | RAP1A | ENSP00000303351 | ENSP00000348786 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | RAP1A, member of RAS oncogene family; Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner | 0.878 |
| ITGB1 | RAP1B | ENSP00000303351 | ENSP00000250559 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | RAP1B, member of RAS oncogene family | 0.864 |
| ITGB1BP1 | CCM2 | ENSP00000347504 | ENSP00000370503 | integrin beta 1 binding protein 1; Regulates integrin signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha- 5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. May play a role in the recruitment of ITGB1 to focal contacts during integrin-dependent cell adhesion | cerebral cavernous malformation 2; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3- dependent p38 activation induced by hyperosmotic shock (By similarity) | 0.748 |
| ITGB1BP1 | ITGB1 | ENSP00000347504 | ENSP00000303351 | integrin beta 1 binding protein 1; Regulates integrin signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha- 5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. May play a role in the recruitment of ITGB1 to focal contacts during integrin-dependent cell adhesion | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.992 |
| ITGB1BP1 | KRIT1 | ENSP00000347504 | ENSP00000344668 | integrin beta 1 binding protein 1; Regulates integrin signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha- 5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. May play a role in the recruitment of ITGB1 to focal contacts during integrin-dependent cell adhesion | KRIT1, ankyrin repeat containing | 0.998 |
| ITGB1BP1 | MYL9 | ENSP00000347504 | ENSP00000279022 | integrin beta 1 binding protein 1; Regulates integrin signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha- 5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. May play a role in the recruitment of ITGB1 to focal contacts during integrin-dependent cell adhesion | myosin, light chain 9, regulatory; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion | 0.662 |
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