Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | KIAA1598 | KIAA1598 (631 aa) | ||||||||||||
Predicted Functional Partners:
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 | PSAT1 | phosphoserine aminotransferase 1; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) (370 aa) |
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0.913 | ||||||||||
 | UNK | unkempt homolog (Drosophila) (886 aa) |
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0.913 | ||||||||||
 | RUFY3 | RUN and FYVE domain containing 3; Implicated in the formation of a single axon by developing neurons. May inhibit the formation of additional axons by inhibition of PI3K in minor neuronal processes (By similarity) (620 aa) |
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0.910 | ||||||||||
 | UBA2 | ubiquitin-like modifier activating enzyme 2; The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (640 aa) |
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0.906 | ||||||||||
 | UBXN1 | UBX domain protein 1; Ubiquitin-binding protein that interacts with the BRCA1- BARD1 heterodimer, and regulates its activity. Specifically binds ’Lys-6’-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1, leads to inhibit the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol (312 aa) |
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0.899 | ||||||||||
 | SEC24A | SEC24 family, member A (S. cerevisiae); Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex (1093 aa) |
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0.893 | ||||||||||
 | AHCYL1 | adenosylhomocysteinase-like 1 (530 aa) |
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0.726 | |||||||||
 | FABP3 | fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor); FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters (133 aa) |
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0.590 | ||||||||||
 | EBF4 | early B-cell factor 4; Transcriptional factor which recognizes variations of the palindromic sequence 5’-ATTCCCNNGGGAATT-3’ (By similarity) (598 aa) |
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0.557 | ||||||||||
 | BBOX1 | butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1; Catalyzes the formation of L-carnitine from gamma- butyrobetaine (387 aa) |
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0.557 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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