| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CPOX | SOX12 | ENSP00000264193 | ENSP00000347646 | coproporphyrinogen oxidase; Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III | SRY (sex determining region Y)-box 12; Binds to the sequence 5’-AACAAT-3’ (By similarity) | 0.732 |
| FKBPL | SOX12 | ENSP00000364298 | ENSP00000347646 | FK506 binding protein like; May be involved in response to X-ray. Regulates p21 protein stability by binding to Hsp90 and p21 | SRY (sex determining region Y)-box 12; Binds to the sequence 5’-AACAAT-3’ (By similarity) | 0.628 |
| KDM6A | SOX12 | ENSP00000367203 | ENSP00000347646 | lysine (K)-specific demethylase 6A; Histone demethylase that specifically demethylates ’Lys- 27’ of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 ’Lys-27’. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of ’Lys-27’ of histone H3 is concomitant with methylation of ’Lys-4’ of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A | SRY (sex determining region Y)-box 12; Binds to the sequence 5’-AACAAT-3’ (By similarity) | 0.632 |
| KDM6A | WT1 | ENSP00000367203 | ENSP00000331327 | lysine (K)-specific demethylase 6A; Histone demethylase that specifically demethylates ’Lys- 27’ of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 ’Lys-27’. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of ’Lys-27’ of histone H3 is concomitant with methylation of ’Lys-4’ of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A | Wilms tumor 1 | 0.498 |
| KDM6B | OGT | ENSP00000254846 | ENSP00000362824 | lysine (K)-specific demethylase 6B; Histone demethylase that specifically demethylates ’Lys- 27’ of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 ’Lys-27’. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation | O-linked N-acetylglucosamine (GlcNAc) transferase; Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta- linked N-acetylglucosamine (O-GlcNAc). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, PFKL, MLL5, MAPT/TAU and HCFC1. Can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing. Involved in insulin resistance in muscle and adipocyte cells via glyc [...] | 0.442 |
| KDM6B | SOX12 | ENSP00000254846 | ENSP00000347646 | lysine (K)-specific demethylase 6B; Histone demethylase that specifically demethylates ’Lys- 27’ of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 ’Lys-27’. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation | SRY (sex determining region Y)-box 12; Binds to the sequence 5’-AACAAT-3’ (By similarity) | 0.632 |
| KDM6B | WT1 | ENSP00000254846 | ENSP00000331327 | lysine (K)-specific demethylase 6B; Histone demethylase that specifically demethylates ’Lys- 27’ of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 ’Lys-27’. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation | Wilms tumor 1 | 0.427 |
| LONRF2 | SOX12 | ENSP00000377086 | ENSP00000347646 | LON peptidase N-terminal domain and ring finger 2 | SRY (sex determining region Y)-box 12; Binds to the sequence 5’-AACAAT-3’ (By similarity) | 0.634 |
| OGT | KDM6B | ENSP00000362824 | ENSP00000254846 | O-linked N-acetylglucosamine (GlcNAc) transferase; Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta- linked N-acetylglucosamine (O-GlcNAc). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, PFKL, MLL5, MAPT/TAU and HCFC1. Can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing. Involved in insulin resistance in muscle and adipocyte cells via glyc [...] | lysine (K)-specific demethylase 6B; Histone demethylase that specifically demethylates ’Lys- 27’ of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 ’Lys-27’. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation | 0.442 |
| OGT | SOX12 | ENSP00000362824 | ENSP00000347646 | O-linked N-acetylglucosamine (GlcNAc) transferase; Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta- linked N-acetylglucosamine (O-GlcNAc). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, PFKL, MLL5, MAPT/TAU and HCFC1. Can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing. Involved in insulin resistance in muscle and adipocyte cells via glyc [...] | SRY (sex determining region Y)-box 12; Binds to the sequence 5’-AACAAT-3’ (By similarity) | 0.632 |
| SOX12 | CPOX | ENSP00000347646 | ENSP00000264193 | SRY (sex determining region Y)-box 12; Binds to the sequence 5’-AACAAT-3’ (By similarity) | coproporphyrinogen oxidase; Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III | 0.732 |
| SOX12 | FKBPL | ENSP00000347646 | ENSP00000364298 | SRY (sex determining region Y)-box 12; Binds to the sequence 5’-AACAAT-3’ (By similarity) | FK506 binding protein like; May be involved in response to X-ray. Regulates p21 protein stability by binding to Hsp90 and p21 | 0.628 |
| SOX12 | KDM6A | ENSP00000347646 | ENSP00000367203 | SRY (sex determining region Y)-box 12; Binds to the sequence 5’-AACAAT-3’ (By similarity) | lysine (K)-specific demethylase 6A; Histone demethylase that specifically demethylates ’Lys- 27’ of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 ’Lys-27’. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of ’Lys-27’ of histone H3 is concomitant with methylation of ’Lys-4’ of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A | 0.632 |
| SOX12 | KDM6B | ENSP00000347646 | ENSP00000254846 | SRY (sex determining region Y)-box 12; Binds to the sequence 5’-AACAAT-3’ (By similarity) | lysine (K)-specific demethylase 6B; Histone demethylase that specifically demethylates ’Lys- 27’ of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 ’Lys-27’. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation | 0.632 |
| SOX12 | LONRF2 | ENSP00000347646 | ENSP00000377086 | SRY (sex determining region Y)-box 12; Binds to the sequence 5’-AACAAT-3’ (By similarity) | LON peptidase N-terminal domain and ring finger 2 | 0.634 |
| SOX12 | OGT | ENSP00000347646 | ENSP00000362824 | SRY (sex determining region Y)-box 12; Binds to the sequence 5’-AACAAT-3’ (By similarity) | O-linked N-acetylglucosamine (GlcNAc) transferase; Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta- linked N-acetylglucosamine (O-GlcNAc). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, PFKL, MLL5, MAPT/TAU and HCFC1. Can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing. Involved in insulin resistance in muscle and adipocyte cells via glyc [...] | 0.632 |
| SOX12 | TMTC1 | ENSP00000347646 | ENSP00000442046 | SRY (sex determining region Y)-box 12; Binds to the sequence 5’-AACAAT-3’ (By similarity) | transmembrane and tetratricopeptide repeat containing 1 | 0.628 |
| SOX12 | TTC6 | ENSP00000347646 | ENSP00000451131 | SRY (sex determining region Y)-box 12; Binds to the sequence 5’-AACAAT-3’ (By similarity) | tetratricopeptide repeat domain 6 | 0.628 |
| SOX12 | UTY | ENSP00000347646 | ENSP00000328939 | SRY (sex determining region Y)-box 12; Binds to the sequence 5’-AACAAT-3’ (By similarity) | ubiquitously transcribed tetratricopeptide repeat containing, Y-linked; Histone demethylase (By similarity) | 0.632 |
| SOX12 | WT1 | ENSP00000347646 | ENSP00000331327 | SRY (sex determining region Y)-box 12; Binds to the sequence 5’-AACAAT-3’ (By similarity) | Wilms tumor 1 | 0.818 |
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