node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
COL18A1 | COL1A2 | ENSP00000347665 | ENSP00000297268 | collagen, type XVIII, alpha 1 | collagen, type I, alpha 2 | 0.950 |
COL18A1 | COL3A1 | ENSP00000347665 | ENSP00000304408 | collagen, type XVIII, alpha 1 | collagen, type III, alpha 1 | 0.955 |
COL18A1 | COL4A5 | ENSP00000347665 | ENSP00000331902 | collagen, type XVIII, alpha 1 | collagen, type IV, alpha 5; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen | 0.960 |
COL18A1 | ITGA5 | ENSP00000347665 | ENSP00000293379 | collagen, type XVIII, alpha 1 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide); Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi’s sarcoma lesions | 0.982 |
COL18A1 | ITGB1 | ENSP00000347665 | ENSP00000303351 | collagen, type XVIII, alpha 1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.961 |
COL18A1 | KDR | ENSP00000347665 | ENSP00000263923 | collagen, type XVIII, alpha 1 | kinase insert domain receptor (a type III receptor tyrosine kinase); Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an importan [...] | 0.976 |
COL18A1 | MMP2 | ENSP00000347665 | ENSP00000219070 | collagen, type XVIII, alpha 1 | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative s [...] | 0.998 |
COL18A1 | MMP9 | ENSP00000347665 | ENSP00000361405 | collagen, type XVIII, alpha 1 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide | 0.991 |
COL18A1 | THBS1 | ENSP00000347665 | ENSP00000260356 | collagen, type XVIII, alpha 1 | thrombospondin 1; Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties | 0.976 |
COL18A1 | TP53 | ENSP00000347665 | ENSP00000269305 | collagen, type XVIII, alpha 1 | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | 0.990 |
COL1A2 | COL18A1 | ENSP00000297268 | ENSP00000347665 | collagen, type I, alpha 2 | collagen, type XVIII, alpha 1 | 0.950 |
COL1A2 | COL3A1 | ENSP00000297268 | ENSP00000304408 | collagen, type I, alpha 2 | collagen, type III, alpha 1 | 0.921 |
COL1A2 | COL4A5 | ENSP00000297268 | ENSP00000331902 | collagen, type I, alpha 2 | collagen, type IV, alpha 5; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen | 0.945 |
COL1A2 | ITGA5 | ENSP00000297268 | ENSP00000293379 | collagen, type I, alpha 2 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide); Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi’s sarcoma lesions | 0.845 |
COL1A2 | ITGB1 | ENSP00000297268 | ENSP00000303351 | collagen, type I, alpha 2 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.928 |
COL1A2 | MMP2 | ENSP00000297268 | ENSP00000219070 | collagen, type I, alpha 2 | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative s [...] | 0.606 |
COL1A2 | MMP9 | ENSP00000297268 | ENSP00000361405 | collagen, type I, alpha 2 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide | 0.773 |
COL1A2 | THBS1 | ENSP00000297268 | ENSP00000260356 | collagen, type I, alpha 2 | thrombospondin 1; Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties | 0.754 |
COL3A1 | COL18A1 | ENSP00000304408 | ENSP00000347665 | collagen, type III, alpha 1 | collagen, type XVIII, alpha 1 | 0.955 |
COL3A1 | COL1A2 | ENSP00000304408 | ENSP00000297268 | collagen, type III, alpha 1 | collagen, type I, alpha 2 | 0.921 |