node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EFHC1 | TRAM2 | ENSP00000360107 | ENSP00000182527 | EF-hand domain (C-terminal) containing 1; May enhance calcium influx through CACNA1E and stimulate programmed cell death | translocation associated membrane protein 2; Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca(2+) concentration at the site of collagen synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in collagen folding | 0.481 |
EFHC1 | ZNF536 | ENSP00000360107 | ENSP00000347730 | EF-hand domain (C-terminal) containing 1; May enhance calcium influx through CACNA1E and stimulate programmed cell death | zinc finger protein 536; May be involved in transcriptional regulation. Recognizes and binds 2 copies of the core DNA sequence 5’-CCCCCA- 3’ | 0.635 |
FBXL19 | ZNF536 | ENSP00000369666 | ENSP00000347730 | F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | zinc finger protein 536; May be involved in transcriptional regulation. Recognizes and binds 2 copies of the core DNA sequence 5’-CCCCCA- 3’ | 0.501 |
FRMD4B | GPR37 | ENSP00000381549 | ENSP00000306449 | FERM domain containing 4B; Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein (By similarity) | G protein-coupled receptor 37 (endothelin receptor type B-like); Orphan receptor. May have a unique functional role in the central nervous system | 0.489 |
FRMD4B | ZNF536 | ENSP00000381549 | ENSP00000347730 | FERM domain containing 4B; Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein (By similarity) | zinc finger protein 536; May be involved in transcriptional regulation. Recognizes and binds 2 copies of the core DNA sequence 5’-CCCCCA- 3’ | 0.501 |
GGA1 | ZNF536 | ENSP00000341344 | ENSP00000347730 | golgi-associated, gamma adaptin ear containing, ARF binding protein 1 | zinc finger protein 536; May be involved in transcriptional regulation. Recognizes and binds 2 copies of the core DNA sequence 5’-CCCCCA- 3’ | 0.484 |
GPR37 | FRMD4B | ENSP00000306449 | ENSP00000381549 | G protein-coupled receptor 37 (endothelin receptor type B-like); Orphan receptor. May have a unique functional role in the central nervous system | FERM domain containing 4B; Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein (By similarity) | 0.489 |
GPR37 | ZNF536 | ENSP00000306449 | ENSP00000347730 | G protein-coupled receptor 37 (endothelin receptor type B-like); Orphan receptor. May have a unique functional role in the central nervous system | zinc finger protein 536; May be involved in transcriptional regulation. Recognizes and binds 2 copies of the core DNA sequence 5’-CCCCCA- 3’ | 0.485 |
KDM2A | ZNF536 | ENSP00000432786 | ENSP00000347730 | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | zinc finger protein 536; May be involved in transcriptional regulation. Recognizes and binds 2 copies of the core DNA sequence 5’-CCCCCA- 3’ | 0.501 |
KDM2B | ZNF536 | ENSP00000366271 | ENSP00000347730 | lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...] | zinc finger protein 536; May be involved in transcriptional regulation. Recognizes and binds 2 copies of the core DNA sequence 5’-CCCCCA- 3’ | 0.501 |
TRAM2 | EFHC1 | ENSP00000182527 | ENSP00000360107 | translocation associated membrane protein 2; Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca(2+) concentration at the site of collagen synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in collagen folding | EF-hand domain (C-terminal) containing 1; May enhance calcium influx through CACNA1E and stimulate programmed cell death | 0.481 |
TRAM2 | ZNF536 | ENSP00000182527 | ENSP00000347730 | translocation associated membrane protein 2; Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca(2+) concentration at the site of collagen synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in collagen folding | zinc finger protein 536; May be involved in transcriptional regulation. Recognizes and binds 2 copies of the core DNA sequence 5’-CCCCCA- 3’ | 0.626 |
TSHZ2 | ZNF536 | ENSP00000360552 | ENSP00000347730 | teashirt zinc finger homeobox 2; Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential) | zinc finger protein 536; May be involved in transcriptional regulation. Recognizes and binds 2 copies of the core DNA sequence 5’-CCCCCA- 3’ | 0.550 |
XRN1 | ZNF536 | ENSP00000264951 | ENSP00000347730 | 5’-3’ exoribonuclease 1; Major 5’-3’ exoribonuclease involved in mRNA decay. Required for the 5’-3’-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS) | zinc finger protein 536; May be involved in transcriptional regulation. Recognizes and binds 2 copies of the core DNA sequence 5’-CCCCCA- 3’ | 0.543 |
ZNF536 | EFHC1 | ENSP00000347730 | ENSP00000360107 | zinc finger protein 536; May be involved in transcriptional regulation. Recognizes and binds 2 copies of the core DNA sequence 5’-CCCCCA- 3’ | EF-hand domain (C-terminal) containing 1; May enhance calcium influx through CACNA1E and stimulate programmed cell death | 0.635 |
ZNF536 | FBXL19 | ENSP00000347730 | ENSP00000369666 | zinc finger protein 536; May be involved in transcriptional regulation. Recognizes and binds 2 copies of the core DNA sequence 5’-CCCCCA- 3’ | F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | 0.501 |
ZNF536 | FRMD4B | ENSP00000347730 | ENSP00000381549 | zinc finger protein 536; May be involved in transcriptional regulation. Recognizes and binds 2 copies of the core DNA sequence 5’-CCCCCA- 3’ | FERM domain containing 4B; Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein (By similarity) | 0.501 |
ZNF536 | GGA1 | ENSP00000347730 | ENSP00000341344 | zinc finger protein 536; May be involved in transcriptional regulation. Recognizes and binds 2 copies of the core DNA sequence 5’-CCCCCA- 3’ | golgi-associated, gamma adaptin ear containing, ARF binding protein 1 | 0.484 |
ZNF536 | GPR37 | ENSP00000347730 | ENSP00000306449 | zinc finger protein 536; May be involved in transcriptional regulation. Recognizes and binds 2 copies of the core DNA sequence 5’-CCCCCA- 3’ | G protein-coupled receptor 37 (endothelin receptor type B-like); Orphan receptor. May have a unique functional role in the central nervous system | 0.485 |
ZNF536 | KDM2A | ENSP00000347730 | ENSP00000432786 | zinc finger protein 536; May be involved in transcriptional regulation. Recognizes and binds 2 copies of the core DNA sequence 5’-CCCCCA- 3’ | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | 0.501 |