TTC30A protein (Homo sapiens) - STRING network view

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TTC30A

tetratricopeptide repeat domain 30A; Required for polyglutamylation of axonemal tubulin (By similarity). Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip (By similarity) (665 aa)

Predicted Functional Partners:

TTC29

0.726

IFT46

0.678

TTC26

0.532

IFT140

0.516

ZNF266

0.505

IFT172

0.499

PDE11A

0.493

ESPNL

0.443

SLITRK3

0.433

RIBC2

0.413

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ESPNL	TTC30A	ENSP00000339115	ENSP00000347915	espin-like	tetratricopeptide repeat domain 30A; Required for polyglutamylation of axonemal tubulin (By similarity). Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip (By similarity)	0.443
IFT140	IFT172	ENSP00000406012	ENSP00000260570	intraflagellar transport 140 homolog (Chlamydomonas); Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Plays a pivotal role in proper development and function of ciliated cells. Involved in ciliogenesis and cilia maintenance	intraflagellar transport 172 homolog (Chlamydomonas); Required for the maintenance and formation of cilia. Plays an indirect role in hedgehog (Hh) signaling, cilia being required for all activity of the hedgehog pathway (By similarity)	0.832
IFT140	IFT46	ENSP00000406012	ENSP00000264020	intraflagellar transport 140 homolog (Chlamydomonas); Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Plays a pivotal role in proper development and function of ciliated cells. Involved in ciliogenesis and cilia maintenance	intraflagellar transport 46 homolog (Chlamydomonas); Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. May play a role in chondrocyte maturation and skeletogenesis (By similarity)	0.790
IFT140	TTC26	ENSP00000406012	ENSP00000419279	intraflagellar transport 140 homolog (Chlamydomonas); Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Plays a pivotal role in proper development and function of ciliated cells. Involved in ciliogenesis and cilia maintenance	tetratricopeptide repeat domain 26; May play a critical role in ciliogenesis and normal cilia function (By similarity)	0.546
IFT140	TTC30A	ENSP00000406012	ENSP00000347915	intraflagellar transport 140 homolog (Chlamydomonas); Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Plays a pivotal role in proper development and function of ciliated cells. Involved in ciliogenesis and cilia maintenance	tetratricopeptide repeat domain 30A; Required for polyglutamylation of axonemal tubulin (By similarity). Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip (By similarity)	0.516
IFT172	IFT140	ENSP00000260570	ENSP00000406012	intraflagellar transport 172 homolog (Chlamydomonas); Required for the maintenance and formation of cilia. Plays an indirect role in hedgehog (Hh) signaling, cilia being required for all activity of the hedgehog pathway (By similarity)	intraflagellar transport 140 homolog (Chlamydomonas); Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Plays a pivotal role in proper development and function of ciliated cells. Involved in ciliogenesis and cilia maintenance	0.832
IFT172	IFT46	ENSP00000260570	ENSP00000264020	intraflagellar transport 172 homolog (Chlamydomonas); Required for the maintenance and formation of cilia. Plays an indirect role in hedgehog (Hh) signaling, cilia being required for all activity of the hedgehog pathway (By similarity)	intraflagellar transport 46 homolog (Chlamydomonas); Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. May play a role in chondrocyte maturation and skeletogenesis (By similarity)	0.760
IFT172	RIBC2	ENSP00000260570	ENSP00000444196	intraflagellar transport 172 homolog (Chlamydomonas); Required for the maintenance and formation of cilia. Plays an indirect role in hedgehog (Hh) signaling, cilia being required for all activity of the hedgehog pathway (By similarity)	RIB43A domain with coiled-coils 2	0.540
IFT172	TTC26	ENSP00000260570	ENSP00000419279	intraflagellar transport 172 homolog (Chlamydomonas); Required for the maintenance and formation of cilia. Plays an indirect role in hedgehog (Hh) signaling, cilia being required for all activity of the hedgehog pathway (By similarity)	tetratricopeptide repeat domain 26; May play a critical role in ciliogenesis and normal cilia function (By similarity)	0.509
IFT172	TTC29	ENSP00000260570	ENSP00000316740	intraflagellar transport 172 homolog (Chlamydomonas); Required for the maintenance and formation of cilia. Plays an indirect role in hedgehog (Hh) signaling, cilia being required for all activity of the hedgehog pathway (By similarity)	tetratricopeptide repeat domain 29	0.502
IFT172	TTC30A	ENSP00000260570	ENSP00000347915	intraflagellar transport 172 homolog (Chlamydomonas); Required for the maintenance and formation of cilia. Plays an indirect role in hedgehog (Hh) signaling, cilia being required for all activity of the hedgehog pathway (By similarity)	tetratricopeptide repeat domain 30A; Required for polyglutamylation of axonemal tubulin (By similarity). Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip (By similarity)	0.499
IFT46	IFT140	ENSP00000264020	ENSP00000406012	intraflagellar transport 46 homolog (Chlamydomonas); Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. May play a role in chondrocyte maturation and skeletogenesis (By similarity)	intraflagellar transport 140 homolog (Chlamydomonas); Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Plays a pivotal role in proper development and function of ciliated cells. Involved in ciliogenesis and cilia maintenance	0.790
IFT46	IFT172	ENSP00000264020	ENSP00000260570	intraflagellar transport 46 homolog (Chlamydomonas); Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. May play a role in chondrocyte maturation and skeletogenesis (By similarity)	intraflagellar transport 172 homolog (Chlamydomonas); Required for the maintenance and formation of cilia. Plays an indirect role in hedgehog (Hh) signaling, cilia being required for all activity of the hedgehog pathway (By similarity)	0.760
IFT46	TTC26	ENSP00000264020	ENSP00000419279	intraflagellar transport 46 homolog (Chlamydomonas); Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. May play a role in chondrocyte maturation and skeletogenesis (By similarity)	tetratricopeptide repeat domain 26; May play a critical role in ciliogenesis and normal cilia function (By similarity)	0.679
IFT46	TTC30A	ENSP00000264020	ENSP00000347915	intraflagellar transport 46 homolog (Chlamydomonas); Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. May play a role in chondrocyte maturation and skeletogenesis (By similarity)	tetratricopeptide repeat domain 30A; Required for polyglutamylation of axonemal tubulin (By similarity). Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip (By similarity)	0.678
PDE11A	TTC30A	ENSP00000286063	ENSP00000347915	phosphodiesterase 11A; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5’-AMP and 5’- GMP, respectively	tetratricopeptide repeat domain 30A; Required for polyglutamylation of axonemal tubulin (By similarity). Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip (By similarity)	0.493
RIBC2	IFT172	ENSP00000444196	ENSP00000260570	RIB43A domain with coiled-coils 2	intraflagellar transport 172 homolog (Chlamydomonas); Required for the maintenance and formation of cilia. Plays an indirect role in hedgehog (Hh) signaling, cilia being required for all activity of the hedgehog pathway (By similarity)	0.540
RIBC2	SLITRK3	ENSP00000444196	ENSP00000241274	RIB43A domain with coiled-coils 2	SLIT and NTRK-like family, member 3; Suppresses neurite outgrowth (By similarity)	0.418
RIBC2	TTC29	ENSP00000444196	ENSP00000316740	RIB43A domain with coiled-coils 2	tetratricopeptide repeat domain 29	0.704
RIBC2	TTC30A	ENSP00000444196	ENSP00000347915	RIB43A domain with coiled-coils 2	tetratricopeptide repeat domain 30A; Required for polyglutamylation of axonemal tubulin (By similarity). Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip (By similarity)	0.413

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