| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCNA1 | UBQLN3 | ENSP00000255465 | ENSP00000347997 | cyclin A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells | ubiquilin 3 | 0.744 |
| DDI1 | NUB1 | ENSP00000302805 | ENSP00000457628 | DNA-damage inducible 1 homolog 1 (S. cerevisiae) | negative regulator of ubiquitin-like proteins 1; Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2 | 0.491 |
| DDI1 | PSMD4 | ENSP00000302805 | ENSP00000357879 | DNA-damage inducible 1 homolog 1 (S. cerevisiae) | proteasome (prosome, macropain) 26S subunit, non-ATPase, 4; Binds and presumably selects ubiquitin-conjugates for destruction. Displays selectivity for longer polyubiquitin chains. Modulates intestinal fluid secretion | 0.906 |
| DDI1 | RAD23B | ENSP00000302805 | ENSP00000350708 | DNA-damage inducible 1 homolog 1 (S. cerevisiae) | RAD23 homolog B (S. cerevisiae); Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum- associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome | 0.897 |
| DDI1 | UBQLN3 | ENSP00000302805 | ENSP00000347997 | DNA-damage inducible 1 homolog 1 (S. cerevisiae) | ubiquilin 3 | 0.597 |
| DDI2 | NUB1 | ENSP00000417748 | ENSP00000457628 | DNA-damage inducible 1 homolog 2 (S. cerevisiae) | negative regulator of ubiquitin-like proteins 1; Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2 | 0.491 |
| DDI2 | PSMD4 | ENSP00000417748 | ENSP00000357879 | DNA-damage inducible 1 homolog 2 (S. cerevisiae) | proteasome (prosome, macropain) 26S subunit, non-ATPase, 4; Binds and presumably selects ubiquitin-conjugates for destruction. Displays selectivity for longer polyubiquitin chains. Modulates intestinal fluid secretion | 0.793 |
| DDI2 | RAD23B | ENSP00000417748 | ENSP00000350708 | DNA-damage inducible 1 homolog 2 (S. cerevisiae) | RAD23 homolog B (S. cerevisiae); Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum- associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome | 0.871 |
| DDI2 | UBQLN3 | ENSP00000417748 | ENSP00000347997 | DNA-damage inducible 1 homolog 2 (S. cerevisiae) | ubiquilin 3 | 0.485 |
| GTSF1L | SPATA3 | ENSP00000362094 | ENSP00000388741 | gametocyte specific factor 1-like | spermatogenesis associated 3 | 0.660 |
| GTSF1L | UBQLN3 | ENSP00000362094 | ENSP00000347997 | gametocyte specific factor 1-like | ubiquilin 3 | 0.470 |
| NRIP2 | NUB1 | ENSP00000337501 | ENSP00000457628 | nuclear receptor interacting protein 2; Down-regulates transcriptional activation by nuclear receptors such as NR1F2 (By similarity) | negative regulator of ubiquitin-like proteins 1; Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2 | 0.491 |
| NRIP2 | PSMD4 | ENSP00000337501 | ENSP00000357879 | nuclear receptor interacting protein 2; Down-regulates transcriptional activation by nuclear receptors such as NR1F2 (By similarity) | proteasome (prosome, macropain) 26S subunit, non-ATPase, 4; Binds and presumably selects ubiquitin-conjugates for destruction. Displays selectivity for longer polyubiquitin chains. Modulates intestinal fluid secretion | 0.772 |
| NRIP2 | RAD23B | ENSP00000337501 | ENSP00000350708 | nuclear receptor interacting protein 2; Down-regulates transcriptional activation by nuclear receptors such as NR1F2 (By similarity) | RAD23 homolog B (S. cerevisiae); Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum- associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome | 0.821 |
| NRIP2 | UBQLN3 | ENSP00000337501 | ENSP00000347997 | nuclear receptor interacting protein 2; Down-regulates transcriptional activation by nuclear receptors such as NR1F2 (By similarity) | ubiquilin 3 | 0.485 |
| NRIP3 | NUB1 | ENSP00000310205 | ENSP00000457628 | nuclear receptor interacting protein 3 | negative regulator of ubiquitin-like proteins 1; Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2 | 0.491 |
| NRIP3 | PSMD4 | ENSP00000310205 | ENSP00000357879 | nuclear receptor interacting protein 3 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 4; Binds and presumably selects ubiquitin-conjugates for destruction. Displays selectivity for longer polyubiquitin chains. Modulates intestinal fluid secretion | 0.772 |
| NRIP3 | RAD23B | ENSP00000310205 | ENSP00000350708 | nuclear receptor interacting protein 3 | RAD23 homolog B (S. cerevisiae); Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum- associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome | 0.821 |
| NRIP3 | UBQLN3 | ENSP00000310205 | ENSP00000347997 | nuclear receptor interacting protein 3 | ubiquilin 3 | 0.486 |
| NUB1 | DDI1 | ENSP00000457628 | ENSP00000302805 | negative regulator of ubiquitin-like proteins 1; Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2 | DNA-damage inducible 1 homolog 1 (S. cerevisiae) | 0.491 |
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