SLC25A46 protein (Homo sapiens) - STRING network view

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Score

SLC25A46

solute carrier family 25, member 46 (418 aa)

Predicted Functional Partners:

REEP5

0.820

TMEM232

0.697

ERAL1

0.670

SCFD1

0.644

MARC1

0.644

LAMTOR1

0.644

ZNF740

0.630

UBC

0.620

FUNDC1

0.531

TBRG1

0.513

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ERAL1	SLC25A46	ENSP00000254928	ENSP00000348211	Era G-protein-like 1 (E. coli); Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3’ terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly	solute carrier family 25, member 46	0.670
ERAL1	UBC	ENSP00000254928	ENSP00000344818	Era G-protein-like 1 (E. coli); Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3’ terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly	ubiquitin C	0.484
FUNDC1	SLC25A46	ENSP00000367284	ENSP00000348211	FUN14 domain containing 1; Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control	solute carrier family 25, member 46	0.531
FUNDC1	UBC	ENSP00000367284	ENSP00000344818	FUN14 domain containing 1; Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control	ubiquitin C	0.483
LAMTOR1	SLC25A46	ENSP00000278671	ENSP00000348211	late endosomal/lysosomal adaptor, MAPK and MTOR activator 1; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible [...]	solute carrier family 25, member 46	0.644
LAMTOR1	UBC	ENSP00000278671	ENSP00000344818	late endosomal/lysosomal adaptor, MAPK and MTOR activator 1; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible [...]	ubiquitin C	0.971
MARC1	SLC25A46	ENSP00000355877	ENSP00000348211	mitochondrial amidoxime reducing component 1	solute carrier family 25, member 46	0.644
MARC1	UBC	ENSP00000355877	ENSP00000344818	mitochondrial amidoxime reducing component 1	ubiquitin C	0.860
REEP5	SLC25A46	ENSP00000368959	ENSP00000348211	receptor accessory protein 5; May promote functional cell surface expression of olfactory receptors	solute carrier family 25, member 46	0.820
REEP5	TBRG1	ENSP00000368959	ENSP00000409016	receptor accessory protein 5; May promote functional cell surface expression of olfactory receptors	transforming growth factor beta regulator 1; Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability	0.609
REEP5	UBC	ENSP00000368959	ENSP00000344818	receptor accessory protein 5; May promote functional cell surface expression of olfactory receptors	ubiquitin C	0.850
REEP5	ZNF740	ENSP00000368959	ENSP00000409463	receptor accessory protein 5; May promote functional cell surface expression of olfactory receptors	zinc finger protein 740; May be involved in transcriptional regulation	0.534
SCFD1	SLC25A46	ENSP00000390783	ENSP00000348211	sec1 family domain containing 1; Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity)	solute carrier family 25, member 46	0.644
SCFD1	UBC	ENSP00000390783	ENSP00000344818	sec1 family domain containing 1; Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity)	ubiquitin C	0.831
SLC25A46	ERAL1	ENSP00000348211	ENSP00000254928	solute carrier family 25, member 46	Era G-protein-like 1 (E. coli); Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3’ terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly	0.670
SLC25A46	FUNDC1	ENSP00000348211	ENSP00000367284	solute carrier family 25, member 46	FUN14 domain containing 1; Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control	0.531
SLC25A46	LAMTOR1	ENSP00000348211	ENSP00000278671	solute carrier family 25, member 46	late endosomal/lysosomal adaptor, MAPK and MTOR activator 1; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible [...]	0.644
SLC25A46	MARC1	ENSP00000348211	ENSP00000355877	solute carrier family 25, member 46	mitochondrial amidoxime reducing component 1	0.644
SLC25A46	REEP5	ENSP00000348211	ENSP00000368959	solute carrier family 25, member 46	receptor accessory protein 5; May promote functional cell surface expression of olfactory receptors	0.820
SLC25A46	SCFD1	ENSP00000348211	ENSP00000390783	solute carrier family 25, member 46	sec1 family domain containing 1; Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity)	0.644

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