| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DDX58 | TRIM4 | ENSP00000369213 | ENSP00000348216 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58; Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include- 5’- triphosphorylated ssRNA and dsRNA and short dsRNA (<1 kb in length). In addition to the 5’-triphosphate moiety, blunt-end base pairing at the 5’-end of the RNA is very essential. Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impac [...] | tripartite motif containing 4 | 0.800 |
| DDX58 | UBC | ENSP00000369213 | ENSP00000344818 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58; Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include- 5’- triphosphorylated ssRNA and dsRNA and short dsRNA (<1 kb in length). In addition to the 5’-triphosphate moiety, blunt-end base pairing at the 5’-end of the RNA is very essential. Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impac [...] | ubiquitin C | 0.999 |
| FAP | TRIM4 | ENSP00000188790 | ENSP00000348216 | fibroblast activation protein, alpha; In association with DPP4 is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May have a role in tissue remodeling during development and wound healing, and may contribute to invasiveness in malignant cancers | tripartite motif containing 4 | 0.526 |
| MDM2 | SSRP1 | ENSP00000417281 | ENSP00000278412 | Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) | structure specific recognition protein 1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the ree [...] | 0.917 |
| MDM2 | TRIM4 | ENSP00000417281 | ENSP00000348216 | Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) | tripartite motif containing 4 | 0.461 |
| MDM2 | UBC | ENSP00000417281 | ENSP00000344818 | Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) | ubiquitin C | 0.999 |
| SSRP1 | MDM2 | ENSP00000278412 | ENSP00000417281 | structure specific recognition protein 1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the ree [...] | Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) | 0.917 |
| SSRP1 | TRIM4 | ENSP00000278412 | ENSP00000348216 | structure specific recognition protein 1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the ree [...] | tripartite motif containing 4 | 0.405 |
| SSRP1 | TRIM41 | ENSP00000278412 | ENSP00000320869 | structure specific recognition protein 1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the ree [...] | tripartite motif containing 41; Functions as an E3 ligase that catalyzes the ubiquitin- mediated degradation of protein kinase C | 0.405 |
| SSRP1 | UBC | ENSP00000278412 | ENSP00000344818 | structure specific recognition protein 1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the ree [...] | ubiquitin C | 0.952 |
| TRIM29 | TRIM4 | ENSP00000343129 | ENSP00000348216 | tripartite motif containing 29; It is able to complement the radiosensitivity defect of an ataxia telangiectasia (AT) fibroblast cell line | tripartite motif containing 4 | 0.548 |
| TRIM4 | DDX58 | ENSP00000348216 | ENSP00000369213 | tripartite motif containing 4 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58; Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include- 5’- triphosphorylated ssRNA and dsRNA and short dsRNA (<1 kb in length). In addition to the 5’-triphosphate moiety, blunt-end base pairing at the 5’-end of the RNA is very essential. Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impac [...] | 0.800 |
| TRIM4 | FAP | ENSP00000348216 | ENSP00000188790 | tripartite motif containing 4 | fibroblast activation protein, alpha; In association with DPP4 is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May have a role in tissue remodeling during development and wound healing, and may contribute to invasiveness in malignant cancers | 0.526 |
| TRIM4 | MDM2 | ENSP00000348216 | ENSP00000417281 | tripartite motif containing 4 | Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) | 0.461 |
| TRIM4 | SSRP1 | ENSP00000348216 | ENSP00000278412 | tripartite motif containing 4 | structure specific recognition protein 1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the ree [...] | 0.405 |
| TRIM4 | TRIM29 | ENSP00000348216 | ENSP00000343129 | tripartite motif containing 4 | tripartite motif containing 29; It is able to complement the radiosensitivity defect of an ataxia telangiectasia (AT) fibroblast cell line | 0.548 |
| TRIM4 | TRIM41 | ENSP00000348216 | ENSP00000320869 | tripartite motif containing 4 | tripartite motif containing 41; Functions as an E3 ligase that catalyzes the ubiquitin- mediated degradation of protein kinase C | 0.461 |
| TRIM4 | UBC | ENSP00000348216 | ENSP00000344818 | tripartite motif containing 4 | ubiquitin C | 0.840 |
| TRIM41 | SSRP1 | ENSP00000320869 | ENSP00000278412 | tripartite motif containing 41; Functions as an E3 ligase that catalyzes the ubiquitin- mediated degradation of protein kinase C | structure specific recognition protein 1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the ree [...] | 0.405 |
| TRIM41 | TRIM4 | ENSP00000320869 | ENSP00000348216 | tripartite motif containing 41; Functions as an E3 ligase that catalyzes the ubiquitin- mediated degradation of protein kinase C | tripartite motif containing 4 | 0.461 |
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