| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CD28 | CD86 | ENSP00000324890 | ENSP00000332049 | CD28 molecule | CD86 molecule; Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T- cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation | 0.990 |
| CD28 | PRKCQ | ENSP00000324890 | ENSP00000263125 | CD28 molecule | protein kinase C, theta; Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non- redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates to the calcium-dependent NFATC1 and NFATC2 transactivat [...] | 0.955 |
| CD28 | STK39 | ENSP00000324890 | ENSP00000348278 | CD28 molecule | serine threonine kinase 39; May act as a mediator of stress-activated signals | 0.900 |
| CD86 | CD28 | ENSP00000332049 | ENSP00000324890 | CD86 molecule; Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T- cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation | CD28 molecule | 0.990 |
| CD86 | PRKCQ | ENSP00000332049 | ENSP00000263125 | CD86 molecule; Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T- cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation | protein kinase C, theta; Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non- redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates to the calcium-dependent NFATC1 and NFATC2 transactivat [...] | 0.900 |
| CD86 | STK39 | ENSP00000332049 | ENSP00000348278 | CD86 molecule; Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T- cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation | serine threonine kinase 39; May act as a mediator of stress-activated signals | 0.900 |
| MBP | STK39 | ENSP00000372025 | ENSP00000348278 | myelin basic protein | serine threonine kinase 39; May act as a mediator of stress-activated signals | 0.925 |
| PRKCQ | CD28 | ENSP00000263125 | ENSP00000324890 | protein kinase C, theta; Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non- redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates to the calcium-dependent NFATC1 and NFATC2 transactivat [...] | CD28 molecule | 0.955 |
| PRKCQ | CD86 | ENSP00000263125 | ENSP00000332049 | protein kinase C, theta; Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non- redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates to the calcium-dependent NFATC1 and NFATC2 transactivat [...] | CD86 molecule; Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T- cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation | 0.900 |
| PRKCQ | STK39 | ENSP00000263125 | ENSP00000348278 | protein kinase C, theta; Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non- redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates to the calcium-dependent NFATC1 and NFATC2 transactivat [...] | serine threonine kinase 39; May act as a mediator of stress-activated signals | 0.954 |
| RELT | STK39 | ENSP00000064780 | ENSP00000348278 | RELT tumor necrosis factor receptor; Mediates activation of NF-kappa-B. May play a role in T- cell activation | serine threonine kinase 39; May act as a mediator of stress-activated signals | 0.927 |
| SLC12A1 | STK39 | ENSP00000370381 | ENSP00000348278 | solute carrier family 12 (sodium/potassium/chloride transporters), member 1; Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume | serine threonine kinase 39; May act as a mediator of stress-activated signals | 0.985 |
| SLC12A1 | WNK4 | ENSP00000370381 | ENSP00000246914 | solute carrier family 12 (sodium/potassium/chloride transporters), member 1; Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume | WNK lysine deficient protein kinase 4; Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+) channel, KCNJ1, via a kinase-i [...] | 0.888 |
| SLC12A2 | STK39 | ENSP00000262461 | ENSP00000348278 | solute carrier family 12 (sodium/potassium/chloride transporters), member 2; Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume | serine threonine kinase 39; May act as a mediator of stress-activated signals | 0.987 |
| SLC12A2 | WNK4 | ENSP00000262461 | ENSP00000246914 | solute carrier family 12 (sodium/potassium/chloride transporters), member 2; Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume | WNK lysine deficient protein kinase 4; Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+) channel, KCNJ1, via a kinase-i [...] | 0.926 |
| SLC12A5 | STK39 | ENSP00000387694 | ENSP00000348278 | solute carrier family 12 (potassium/chloride transporter), member 5; Mediates electroneutral potassium-chloride cotransport in mature neurons. Transport occurs under isotonic conditions, but is activated 20-fold by cell swelling. Important for Cl(-) homeostasis in neurons | serine threonine kinase 39; May act as a mediator of stress-activated signals | 0.954 |
| SLC12A5 | WNK4 | ENSP00000387694 | ENSP00000246914 | solute carrier family 12 (potassium/chloride transporter), member 5; Mediates electroneutral potassium-chloride cotransport in mature neurons. Transport occurs under isotonic conditions, but is activated 20-fold by cell swelling. Important for Cl(-) homeostasis in neurons | WNK lysine deficient protein kinase 4; Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+) channel, KCNJ1, via a kinase-i [...] | 0.743 |
| SLC12A6 | STK39 | ENSP00000452776 | ENSP00000348278 | solute carrier family 12 (potassium/chloride transporters), member 6 | serine threonine kinase 39; May act as a mediator of stress-activated signals | 0.981 |
| SLC12A6 | WNK4 | ENSP00000452776 | ENSP00000246914 | solute carrier family 12 (potassium/chloride transporters), member 6 | WNK lysine deficient protein kinase 4; Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+) channel, KCNJ1, via a kinase-i [...] | 0.591 |
| STK39 | CD28 | ENSP00000348278 | ENSP00000324890 | serine threonine kinase 39; May act as a mediator of stress-activated signals | CD28 molecule | 0.900 |
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