node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BMP4 | MAPK9 | ENSP00000245451 | ENSP00000389338 | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | mitogen-activated protein kinase 9 | 0.777 |
BMP4 | MMP23B | ENSP00000245451 | ENSP00000348308 | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | matrix metallopeptidase 23B | 0.802 |
CCL2 | CXCL1 | ENSP00000225831 | ENSP00000379110 | chemokine (C-C motif) ligand 2; Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha); Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO- alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity | 0.757 |
CCL2 | MMP23B | ENSP00000225831 | ENSP00000348308 | chemokine (C-C motif) ligand 2; Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis | matrix metallopeptidase 23B | 0.800 |
CDK11A | CDK11B | ENSP00000384442 | ENSP00000464036 | cyclin-dependent kinase 11A | cyclin-dependent kinase 11B | 0.812 |
CDK11A | MMP23B | ENSP00000384442 | ENSP00000348308 | cyclin-dependent kinase 11A | matrix metallopeptidase 23B | 0.860 |
CDK11B | CDK11A | ENSP00000464036 | ENSP00000384442 | cyclin-dependent kinase 11B | cyclin-dependent kinase 11A | 0.812 |
CDK11B | MMP23B | ENSP00000464036 | ENSP00000348308 | cyclin-dependent kinase 11B | matrix metallopeptidase 23B | 0.861 |
CDK13 | MMP23B | ENSP00000181839 | ENSP00000348308 | cyclin-dependent kinase 13 | matrix metallopeptidase 23B | 0.886 |
CXCL1 | CCL2 | ENSP00000379110 | ENSP00000225831 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha); Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO- alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity | chemokine (C-C motif) ligand 2; Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis | 0.757 |
CXCL1 | MMP23B | ENSP00000379110 | ENSP00000348308 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha); Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO- alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity | matrix metallopeptidase 23B | 0.815 |
MAPK9 | BMP4 | ENSP00000389338 | ENSP00000245451 | mitogen-activated protein kinase 9 | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | 0.777 |
MAPK9 | MMP23B | ENSP00000389338 | ENSP00000348308 | mitogen-activated protein kinase 9 | matrix metallopeptidase 23B | 0.609 |
MAPK9 | MMP28 | ENSP00000389338 | ENSP00000250144 | mitogen-activated protein kinase 9 | matrix metallopeptidase 28; Can degrade casein. Could play a role in tissues homeostasis and repair | 0.609 |
MMP23B | BMP4 | ENSP00000348308 | ENSP00000245451 | matrix metallopeptidase 23B | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | 0.802 |
MMP23B | CCL2 | ENSP00000348308 | ENSP00000225831 | matrix metallopeptidase 23B | chemokine (C-C motif) ligand 2; Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis | 0.800 |
MMP23B | CDK11A | ENSP00000348308 | ENSP00000384442 | matrix metallopeptidase 23B | cyclin-dependent kinase 11A | 0.860 |
MMP23B | CDK11B | ENSP00000348308 | ENSP00000464036 | matrix metallopeptidase 23B | cyclin-dependent kinase 11B | 0.861 |
MMP23B | CDK13 | ENSP00000348308 | ENSP00000181839 | matrix metallopeptidase 23B | cyclin-dependent kinase 13 | 0.886 |
MMP23B | CXCL1 | ENSP00000348308 | ENSP00000379110 | matrix metallopeptidase 23B | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha); Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO- alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity | 0.815 |