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STRINGSTRING
COL15A1 COL15A1 COL22A1 COL22A1 COL9A2 COL9A2 COL6A1 COL6A1 COL5A1 COL5A1 COL24A1 COL24A1 COL5A3 COL5A3 COL1A1 COL1A1 COL27A1 COL27A1 COL18A1 COL18A1 PTK2 PTK2
"COL27A1" - collagen, type XXVII, alpha 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
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Cooccurence
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Experiments
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[Homology]
Score
COL27A1collagen, type XXVII, alpha 1; Plays a role during the calcification of cartilage and the transition of cartilage to bone (1860 aa)    
Predicted Functional Partners:
COL22A1
collagen, type XXII, alpha 1; Acts as a cell adhesion ligand for skin epithelial cells and fibroblasts (1626 aa)
          score_image score_image   0.932
COL24A1
collagen, type XXIV, alpha 1; May participate in regulating type I collagen fibrillogenesis at specific anatomical locations during fetal development (1714 aa)
          score_image score_image score_image 0.926
COL5A3
collagen, type V, alpha 3; Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin (1745 aa)
          score_image score_image score_image 0.924
COL5A1
collagen, type V, alpha 1; Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin (1838 aa)
          score_image score_image score_image 0.920
PTK2
PTK2 protein tyrosine kinase 2; Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; req [...] (1065 aa)
          score_image score_image   0.919
COL1A1
collagen, type I, alpha 1 (1464 aa)
          score_image score_image score_image 0.919
COL15A1
collagen, type XV, alpha 1; Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle (1388 aa)
          score_image score_image score_image 0.918
COL18A1
collagen, type XVIII, alpha 1 (1519 aa)
          score_image score_image score_image 0.916
COL9A2
collagen, type IX, alpha 2; Structural component of hyaline cartilage and vitreous of the eye (689 aa)
          score_image score_image score_image 0.914
COL6A1
collagen, type VI, alpha 1; Collagen VI acts as a cell-binding protein (1028 aa)
      score_image   score_image score_image score_image 0.913
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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