GTF3C1 protein (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Size

small nodes:
protein of unknown 3D structure

large nodes:
some 3D structure is known or predicted

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

GTF3C1

general transcription factor IIIC, polypeptide 1, alpha 220kDa; Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element (2109 aa)

Predicted Functional Partners:

GTF3C2

0.999

GTF3C4

0.999

GTF3C5

0.999

GTF3C3

0.999

GTF3A

0.998

BDP1

0.998

GTF3C6

0.997

BRF1

0.986

TBP

0.973

POLR3F

0.964

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BDP1	BRF1	ENSP00000351575	ENSP00000448323	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB	BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)	0.997
BDP1	GTF3A	ENSP00000351575	ENSP00000370532	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB	general transcription factor IIIA; Interacts with the internal control region (ICR) of approximately 50 bases within the 5S RNA genes, is required for correct transcription of these genes by RNA polymerase III. Also binds the transcribed 5S RNA’s. May initiate transcription of the 5S ribosomal RNA gene and maintain the stability of transcription of other genes	0.981
BDP1	GTF3C1	ENSP00000351575	ENSP00000348510	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB	general transcription factor IIIC, polypeptide 1, alpha 220kDa; Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element	0.998
BDP1	GTF3C2	ENSP00000351575	ENSP00000264720	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB	general transcription factor IIIC, polypeptide 2, beta 110kDa; Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1	0.951
BDP1	GTF3C3	ENSP00000351575	ENSP00000263956	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB	general transcription factor IIIC, polypeptide 3, 102kDa; Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters	0.995
BDP1	GTF3C4	ENSP00000351575	ENSP00000361219	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB	general transcription factor IIIC, polypeptide 4, 90kDa; Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. Has histone acetyltransferase activity (HAT) with unique specificity for free and nucleosomal H3. May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F. May be localized close to the A box	0.952
BDP1	GTF3C5	ENSP00000351575	ENSP00000361180	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB	general transcription factor IIIC, polypeptide 5, 63kDa	0.969
BDP1	POLR3F	ENSP00000351575	ENSP00000366828	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB	polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct RNA Pol III binding to the TFIIIB-DNA complex. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcript [...]	0.982
BDP1	TBP	ENSP00000351575	ENSP00000230354	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB	TATA box binding protein; General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre- initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1 wi [...]	0.998
BRF1	BDP1	ENSP00000448323	ENSP00000351575	BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB	0.997
BRF1	GTF3A	ENSP00000448323	ENSP00000370532	BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)	general transcription factor IIIA; Interacts with the internal control region (ICR) of approximately 50 bases within the 5S RNA genes, is required for correct transcription of these genes by RNA polymerase III. Also binds the transcribed 5S RNA’s. May initiate transcription of the 5S ribosomal RNA gene and maintain the stability of transcription of other genes	0.971
BRF1	GTF3C1	ENSP00000448323	ENSP00000348510	BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)	general transcription factor IIIC, polypeptide 1, alpha 220kDa; Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element	0.986
BRF1	GTF3C2	ENSP00000448323	ENSP00000264720	BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)	general transcription factor IIIC, polypeptide 2, beta 110kDa; Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1	0.929
BRF1	GTF3C3	ENSP00000448323	ENSP00000263956	BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)	general transcription factor IIIC, polypeptide 3, 102kDa; Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters	0.999
BRF1	GTF3C4	ENSP00000448323	ENSP00000361219	BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)	general transcription factor IIIC, polypeptide 4, 90kDa; Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. Has histone acetyltransferase activity (HAT) with unique specificity for free and nucleosomal H3. May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F. May be localized close to the A box	0.988
BRF1	GTF3C5	ENSP00000448323	ENSP00000361180	BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)	general transcription factor IIIC, polypeptide 5, 63kDa	0.995
BRF1	GTF3C6	ENSP00000448323	ENSP00000357863	BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)	general transcription factor IIIC, polypeptide 6, alpha 35kDa; Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters	0.720
BRF1	POLR3F	ENSP00000448323	ENSP00000366828	BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)	polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct RNA Pol III binding to the TFIIIB-DNA complex. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcript [...]	0.995
BRF1	TBP	ENSP00000448323	ENSP00000230354	BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)	TATA box binding protein; General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre- initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1 wi [...]	0.999
GTF3A	BDP1	ENSP00000370532	ENSP00000351575	general transcription factor IIIA; Interacts with the internal control region (ICR) of approximately 50 bases within the 5S RNA genes, is required for correct transcription of these genes by RNA polymerase III. Also binds the transcribed 5S RNA’s. May initiate transcription of the 5S ribosomal RNA gene and maintain the stability of transcription of other genes	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB	0.981

page 1 of 6

Experiments

Cooccurrence

Databases

Neighborhood

Textmining

Fusion

Coexpression

© STRING Consortium 2017

Credits

Access

Info

About