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MCOLN1 MCOLN1 PRCD PRCD RPGR RPGR JMJD6 JMJD6 MCOLN2 MCOLN2 FRMD6 FRMD6 WDR7 WDR7 RASSF8 RASSF8 WWC1 WWC1 NF2 NF2 COX6B2 COX6B2
"FRMD6" - FERM domain containing 6 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
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colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
FRMD6FERM domain containing 6 (614 aa)    
Predicted Functional Partners:
WWC1
WW and C2 domain containing 1; Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates dir [...] (1119 aa)
          score_image score_image   0.863
NF2
neurofibromin 2 (merlin) (595 aa)
          score_image score_image score_image 0.817
MCOLN1
mucolipin 1; Cation channel probably playing a role in the endocytic pathway and in the control of membrane trafficking of proteins and lipids. Could play a major role in Ca(2+) transport regulating lysosomal exocytosis (580 aa)
            score_image   0.753
PRCD
progressive rod-cone degeneration; Involved in vision (54 aa)
            score_image   0.681
RPGR
retinitis pigmentosa GTPase regulator (1152 aa)
            score_image   0.606
COX6B2
cytochrome c oxidase subunit VIb polypeptide 2 (testis); Connects the two COX monomers into the physiological dimeric form (By similarity) (88 aa)
        score_image       0.594
WDR7
WD repeat domain 7 (1490 aa)
        score_image       0.594
JMJD6
jumonji domain containing 6; Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as a RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates [...] (414 aa)
        score_image   score_image   0.553
RASSF8
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 (419 aa)
        score_image       0.530
MCOLN2
mucolipin 2 (566 aa)
            score_image   0.512
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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