node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKAP9 | CDK5RAP2 | ENSP00000348573 | ENSP00000343818 | A kinase (PRKA) anchor protein (yotiao) 9 | CDK5 regulatory subunit associated protein 2 | 0.963 |
AKAP9 | GRIN1 | ENSP00000348573 | ENSP00000360608 | A kinase (PRKA) anchor protein (yotiao) 9 | glutamate receptor, ionotropic, N-methyl D-aspartate 1 | 0.974 |
AKAP9 | KCNQ1 | ENSP00000348573 | ENSP00000155840 | A kinase (PRKA) anchor protein (yotiao) 9 | potassium voltage-gated channel, KQT-like subfamily, member 1; Probably important in cardiac repolarization. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current in CHO cells in which cloned KCNQ1/KCNE1 channels were coexpressed with M1 muscarinic receptors. May associate also with KCNE3 (MiRP2) to form the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions, which is reduced in [...] | 0.986 |
AKAP9 | PCNT | ENSP00000348573 | ENSP00000352572 | A kinase (PRKA) anchor protein (yotiao) 9 | pericentrin; Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome | 0.987 |
AKAP9 | PKN1 | ENSP00000348573 | ENSP00000343325 | A kinase (PRKA) anchor protein (yotiao) 9 | protein kinase N1; PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates ’Ser-575’, ’Ser-637’ and ’Ser-669’ of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen r [...] | 0.994 |
AKAP9 | PRKACB | ENSP00000348573 | ENSP00000359719 | A kinase (PRKA) anchor protein (yotiao) 9 | protein kinase, cAMP-dependent, catalytic, beta | 0.972 |
AKAP9 | PRKAR2A | ENSP00000348573 | ENSP00000265563 | A kinase (PRKA) anchor protein (yotiao) 9 | protein kinase, cAMP-dependent, regulatory, type II, alpha; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase | 0.992 |
AKAP9 | PRKAR2B | ENSP00000348573 | ENSP00000265717 | A kinase (PRKA) anchor protein (yotiao) 9 | protein kinase, cAMP-dependent, regulatory, type II, beta; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase | 0.969 |
AKAP9 | TUBGCP2 | ENSP00000348573 | ENSP00000252936 | A kinase (PRKA) anchor protein (yotiao) 9 | tubulin, gamma complex associated protein 2; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome | 0.965 |
AKAP9 | TUBGCP3 | ENSP00000348573 | ENSP00000261965 | A kinase (PRKA) anchor protein (yotiao) 9 | tubulin, gamma complex associated protein 3; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome | 0.967 |
CDK5RAP2 | AKAP9 | ENSP00000343818 | ENSP00000348573 | CDK5 regulatory subunit associated protein 2 | A kinase (PRKA) anchor protein (yotiao) 9 | 0.963 |
CDK5RAP2 | PCNT | ENSP00000343818 | ENSP00000352572 | CDK5 regulatory subunit associated protein 2 | pericentrin; Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome | 0.995 |
CDK5RAP2 | PRKACB | ENSP00000343818 | ENSP00000359719 | CDK5 regulatory subunit associated protein 2 | protein kinase, cAMP-dependent, catalytic, beta | 0.765 |
CDK5RAP2 | PRKAR2B | ENSP00000343818 | ENSP00000265717 | CDK5 regulatory subunit associated protein 2 | protein kinase, cAMP-dependent, regulatory, type II, beta; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase | 0.900 |
CDK5RAP2 | TUBGCP2 | ENSP00000343818 | ENSP00000252936 | CDK5 regulatory subunit associated protein 2 | tubulin, gamma complex associated protein 2; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome | 0.960 |
CDK5RAP2 | TUBGCP3 | ENSP00000343818 | ENSP00000261965 | CDK5 regulatory subunit associated protein 2 | tubulin, gamma complex associated protein 3; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome | 0.966 |
GRIN1 | AKAP9 | ENSP00000360608 | ENSP00000348573 | glutamate receptor, ionotropic, N-methyl D-aspartate 1 | A kinase (PRKA) anchor protein (yotiao) 9 | 0.974 |
GRIN1 | PRKACB | ENSP00000360608 | ENSP00000359719 | glutamate receptor, ionotropic, N-methyl D-aspartate 1 | protein kinase, cAMP-dependent, catalytic, beta | 0.822 |
KCNQ1 | AKAP9 | ENSP00000155840 | ENSP00000348573 | potassium voltage-gated channel, KQT-like subfamily, member 1; Probably important in cardiac repolarization. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current in CHO cells in which cloned KCNQ1/KCNE1 channels were coexpressed with M1 muscarinic receptors. May associate also with KCNE3 (MiRP2) to form the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions, which is reduced in [...] | A kinase (PRKA) anchor protein (yotiao) 9 | 0.986 |
KCNQ1 | PRKACB | ENSP00000155840 | ENSP00000359719 | potassium voltage-gated channel, KQT-like subfamily, member 1; Probably important in cardiac repolarization. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current in CHO cells in which cloned KCNQ1/KCNE1 channels were coexpressed with M1 muscarinic receptors. May associate also with KCNE3 (MiRP2) to form the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions, which is reduced in [...] | protein kinase, cAMP-dependent, catalytic, beta | 0.800 |