| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| COPG1 | JPH4 | ENSP00000325002 | ENSP00000348648 | coatomer protein complex, subunit gamma 1; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; t [...] | junctophilin 4; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH4 is brain- specific and appears to have an active role in certain neurons involved in motor coordination and memory (By similarity) | 0.440 |
| FAM171B | FAM189A1 | ENSP00000304108 | ENSP00000261275 | family with sequence similarity 171, member B | family with sequence similarity 189, member A1 | 0.678 |
| FAM171B | FAM19A2 | ENSP00000304108 | ENSP00000393987 | family with sequence similarity 171, member B | family with sequence similarity 19 (chemokine (C-C motif)-like), member A2 | 0.677 |
| FAM171B | JPH4 | ENSP00000304108 | ENSP00000348648 | family with sequence similarity 171, member B | junctophilin 4; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH4 is brain- specific and appears to have an active role in certain neurons involved in motor coordination and memory (By similarity) | 0.429 |
| FAM171B | TMEM145 | ENSP00000304108 | ENSP00000301204 | family with sequence similarity 171, member B | transmembrane protein 145 | 0.686 |
| FAM189A1 | FAM171B | ENSP00000261275 | ENSP00000304108 | family with sequence similarity 189, member A1 | family with sequence similarity 171, member B | 0.678 |
| FAM189A1 | FAM19A2 | ENSP00000261275 | ENSP00000393987 | family with sequence similarity 189, member A1 | family with sequence similarity 19 (chemokine (C-C motif)-like), member A2 | 0.675 |
| FAM189A1 | JPH4 | ENSP00000261275 | ENSP00000348648 | family with sequence similarity 189, member A1 | junctophilin 4; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH4 is brain- specific and appears to have an active role in certain neurons involved in motor coordination and memory (By similarity) | 0.422 |
| FAM189A1 | TMEM145 | ENSP00000261275 | ENSP00000301204 | family with sequence similarity 189, member A1 | transmembrane protein 145 | 0.681 |
| FAM19A2 | FAM171B | ENSP00000393987 | ENSP00000304108 | family with sequence similarity 19 (chemokine (C-C motif)-like), member A2 | family with sequence similarity 171, member B | 0.677 |
| FAM19A2 | FAM189A1 | ENSP00000393987 | ENSP00000261275 | family with sequence similarity 19 (chemokine (C-C motif)-like), member A2 | family with sequence similarity 189, member A1 | 0.675 |
| FAM19A2 | JPH4 | ENSP00000393987 | ENSP00000348648 | family with sequence similarity 19 (chemokine (C-C motif)-like), member A2 | junctophilin 4; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH4 is brain- specific and appears to have an active role in certain neurons involved in motor coordination and memory (By similarity) | 0.420 |
| FAM19A2 | TMEM145 | ENSP00000393987 | ENSP00000301204 | family with sequence similarity 19 (chemokine (C-C motif)-like), member A2 | transmembrane protein 145 | 0.680 |
| GYG1 | GYG2 | ENSP00000340736 | ENSP00000370555 | glycogenin 1; Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase | glycogenin 2; Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase | 0.957 |
| GYG1 | JPH4 | ENSP00000340736 | ENSP00000348648 | glycogenin 1; Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase | junctophilin 4; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH4 is brain- specific and appears to have an active role in certain neurons involved in motor coordination and memory (By similarity) | 0.474 |
| GYG2 | GYG1 | ENSP00000370555 | ENSP00000340736 | glycogenin 2; Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase | glycogenin 1; Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase | 0.957 |
| GYG2 | JPH4 | ENSP00000370555 | ENSP00000348648 | glycogenin 2; Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase | junctophilin 4; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH4 is brain- specific and appears to have an active role in certain neurons involved in motor coordination and memory (By similarity) | 0.459 |
| HMX2 | JPH4 | ENSP00000341108 | ENSP00000348648 | H6 family homeobox 2; Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development (By similarity) | junctophilin 4; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH4 is brain- specific and appears to have an active role in certain neurons involved in motor coordination and memory (By similarity) | 0.462 |
| JPH4 | COPG1 | ENSP00000348648 | ENSP00000325002 | junctophilin 4; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH4 is brain- specific and appears to have an active role in certain neurons involved in motor coordination and memory (By similarity) | coatomer protein complex, subunit gamma 1; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; t [...] | 0.440 |
| JPH4 | FAM171B | ENSP00000348648 | ENSP00000304108 | junctophilin 4; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH4 is brain- specific and appears to have an active role in certain neurons involved in motor coordination and memory (By similarity) | family with sequence similarity 171, member B | 0.429 |
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