| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DSG1 | EML6 | ENSP00000257192 | ENSP00000348842 | desmoglein 1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion | echinoderm microtubule associated protein like 6; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity) | 0.473 |
| EML6 | DSG1 | ENSP00000348842 | ENSP00000257192 | echinoderm microtubule associated protein like 6; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity) | desmoglein 1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion | 0.473 |
| EML6 | GLDC | ENSP00000348842 | ENSP00000370737 | echinoderm microtubule associated protein like 6; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity) | glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein | 0.530 |
| EML6 | LIMA1 | ENSP00000348842 | ENSP00000378400 | echinoderm microtubule associated protein like 6; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity) | LIM domain and actin binding 1 | 0.514 |
| EML6 | PCNXL2 | ENSP00000348842 | ENSP00000258229 | echinoderm microtubule associated protein like 6; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity) | pecanex-like 2 (Drosophila); May play a role in tumorigenesis of colorectal carcinomas with high microsatellite instability (MSI-H) | 0.423 |
| EML6 | POLG2 | ENSP00000348842 | ENSP00000442563 | echinoderm microtubule associated protein like 6; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity) | polymerase (DNA directed), gamma 2, accessory subunit; Mitochondrial polymerase processivity subunit. Stimulates the polymerase and exonuclease activities, and increases the processivity of the enzyme. Binds to ss-DNA | 0.486 |
| EML6 | STK38 | ENSP00000348842 | ENSP00000229812 | echinoderm microtubule associated protein like 6; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity) | serine/threonine kinase 38; Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2 | 0.414 |
| EML6 | TEX10 | ENSP00000348842 | ENSP00000364037 | echinoderm microtubule associated protein like 6; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity) | testis expressed 10; Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes | 0.457 |
| EML6 | WDR77 | ENSP00000348842 | ENSP00000235090 | echinoderm microtubule associated protein like 6; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity) | WD repeat domain 77; Non-catalytic component of the 20S PRMT5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The 20S PRMT5-containing methyltransferase complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor [...] | 0.453 |
| EML6 | ZMIZ1 | ENSP00000348842 | ENSP00000334474 | echinoderm microtubule associated protein like 6; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity) | zinc finger, MIZ-type containing 1; Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation | 0.444 |
| EML6 | ZMIZ2 | ENSP00000348842 | ENSP00000311778 | echinoderm microtubule associated protein like 6; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity) | zinc finger, MIZ-type containing 2 | 0.444 |
| GLDC | EML6 | ENSP00000370737 | ENSP00000348842 | glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein | echinoderm microtubule associated protein like 6; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity) | 0.530 |
| LIMA1 | EML6 | ENSP00000378400 | ENSP00000348842 | LIM domain and actin binding 1 | echinoderm microtubule associated protein like 6; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity) | 0.514 |
| PCNXL2 | EML6 | ENSP00000258229 | ENSP00000348842 | pecanex-like 2 (Drosophila); May play a role in tumorigenesis of colorectal carcinomas with high microsatellite instability (MSI-H) | echinoderm microtubule associated protein like 6; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity) | 0.423 |
| POLG2 | EML6 | ENSP00000442563 | ENSP00000348842 | polymerase (DNA directed), gamma 2, accessory subunit; Mitochondrial polymerase processivity subunit. Stimulates the polymerase and exonuclease activities, and increases the processivity of the enzyme. Binds to ss-DNA | echinoderm microtubule associated protein like 6; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity) | 0.486 |
| STK38 | EML6 | ENSP00000229812 | ENSP00000348842 | serine/threonine kinase 38; Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2 | echinoderm microtubule associated protein like 6; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity) | 0.414 |
| TEX10 | EML6 | ENSP00000364037 | ENSP00000348842 | testis expressed 10; Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes | echinoderm microtubule associated protein like 6; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity) | 0.457 |
| WDR77 | EML6 | ENSP00000235090 | ENSP00000348842 | WD repeat domain 77; Non-catalytic component of the 20S PRMT5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The 20S PRMT5-containing methyltransferase complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor [...] | echinoderm microtubule associated protein like 6; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity) | 0.453 |
| ZMIZ1 | EML6 | ENSP00000334474 | ENSP00000348842 | zinc finger, MIZ-type containing 1; Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation | echinoderm microtubule associated protein like 6; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity) | 0.444 |
| ZMIZ2 | EML6 | ENSP00000311778 | ENSP00000348842 | zinc finger, MIZ-type containing 2 | echinoderm microtubule associated protein like 6; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity) | 0.444 |
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