node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATG2A | ATG2B | ENSP00000366475 | ENSP00000353010 | autophagy related 2A; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | autophagy related 2B; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | 0.621 |
ATG2A | ATG7 | ENSP00000366475 | ENSP00000346437 | autophagy related 2A; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | autophagy related 7; Functions as an E1 enzyme essential for multisubstrates such as ATG8-like proteins and ATG12. Forms intermediate conjugates with ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). PE-conjugation to ATG8-like proteins is essential for autophagy. Also acts as an E1 enzyme for ATG12 conjugation to ATG5 and ATG3 (By similarity) | 0.624 |
ATG2A | ATG9A | ENSP00000366475 | ENSP00000355173 | autophagy related 2A; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | autophagy related 9A | 0.976 |
ATG2A | BECN1 | ENSP00000366475 | ENSP00000355231 | autophagy related 2A; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | beclin 1, autophagy related; Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus | 0.634 |
ATG2A | KBTBD7 | ENSP00000366475 | ENSP00000368797 | autophagy related 2A; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | kelch repeat and BTB (POZ) domain containing 7 | 0.454 |
ATG2A | ULK1 | ENSP00000366475 | ENSP00000324560 | autophagy related 2A; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | unc-51-like kinase 1 (C. elegans); Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy- acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading [...] | 0.807 |
ATG2A | WDR45 | ENSP00000366475 | ENSP00000348848 | autophagy related 2A; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | WD repeat domain 45 | 0.790 |
ATG2B | ATG2A | ENSP00000353010 | ENSP00000366475 | autophagy related 2B; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | autophagy related 2A; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | 0.621 |
ATG2B | ATG7 | ENSP00000353010 | ENSP00000346437 | autophagy related 2B; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | autophagy related 7; Functions as an E1 enzyme essential for multisubstrates such as ATG8-like proteins and ATG12. Forms intermediate conjugates with ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). PE-conjugation to ATG8-like proteins is essential for autophagy. Also acts as an E1 enzyme for ATG12 conjugation to ATG5 and ATG3 (By similarity) | 0.665 |
ATG2B | ATG9A | ENSP00000353010 | ENSP00000355173 | autophagy related 2B; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | autophagy related 9A | 0.969 |
ATG2B | BECN1 | ENSP00000353010 | ENSP00000355231 | autophagy related 2B; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | beclin 1, autophagy related; Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus | 0.680 |
ATG2B | KBTBD7 | ENSP00000353010 | ENSP00000368797 | autophagy related 2B; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | kelch repeat and BTB (POZ) domain containing 7 | 0.481 |
ATG2B | ULK1 | ENSP00000353010 | ENSP00000324560 | autophagy related 2B; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | unc-51-like kinase 1 (C. elegans); Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy- acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading [...] | 0.824 |
ATG2B | WDR45 | ENSP00000353010 | ENSP00000348848 | autophagy related 2B; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | WD repeat domain 45 | 0.999 |
ATG7 | ATG2A | ENSP00000346437 | ENSP00000366475 | autophagy related 7; Functions as an E1 enzyme essential for multisubstrates such as ATG8-like proteins and ATG12. Forms intermediate conjugates with ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). PE-conjugation to ATG8-like proteins is essential for autophagy. Also acts as an E1 enzyme for ATG12 conjugation to ATG5 and ATG3 (By similarity) | autophagy related 2A; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | 0.624 |
ATG7 | ATG2B | ENSP00000346437 | ENSP00000353010 | autophagy related 7; Functions as an E1 enzyme essential for multisubstrates such as ATG8-like proteins and ATG12. Forms intermediate conjugates with ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). PE-conjugation to ATG8-like proteins is essential for autophagy. Also acts as an E1 enzyme for ATG12 conjugation to ATG5 and ATG3 (By similarity) | autophagy related 2B; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | 0.665 |
ATG7 | ATG9A | ENSP00000346437 | ENSP00000355173 | autophagy related 7; Functions as an E1 enzyme essential for multisubstrates such as ATG8-like proteins and ATG12. Forms intermediate conjugates with ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). PE-conjugation to ATG8-like proteins is essential for autophagy. Also acts as an E1 enzyme for ATG12 conjugation to ATG5 and ATG3 (By similarity) | autophagy related 9A | 0.873 |
ATG7 | BECN1 | ENSP00000346437 | ENSP00000355231 | autophagy related 7; Functions as an E1 enzyme essential for multisubstrates such as ATG8-like proteins and ATG12. Forms intermediate conjugates with ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). PE-conjugation to ATG8-like proteins is essential for autophagy. Also acts as an E1 enzyme for ATG12 conjugation to ATG5 and ATG3 (By similarity) | beclin 1, autophagy related; Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus | 0.972 |
ATG7 | NBR1 | ENSP00000346437 | ENSP00000343479 | autophagy related 7; Functions as an E1 enzyme essential for multisubstrates such as ATG8-like proteins and ATG12. Forms intermediate conjugates with ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). PE-conjugation to ATG8-like proteins is essential for autophagy. Also acts as an E1 enzyme for ATG12 conjugation to ATG5 and ATG3 (By similarity) | neighbor of BRCA1 gene 1; Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets | 0.788 |
ATG7 | PIKFYVE | ENSP00000346437 | ENSP00000264380 | autophagy related 7; Functions as an E1 enzyme essential for multisubstrates such as ATG8-like proteins and ATG12. Forms intermediate conjugates with ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). PE-conjugation to ATG8-like proteins is essential for autophagy. Also acts as an E1 enzyme for ATG12 conjugation to ATG5 and ATG3 (By similarity) | phosphoinositide kinase, FYVE finger containing; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo- inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes | 0.519 |