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KBTBD7 KBTBD7 ATG2A ATG2A ATG2B ATG2B ATG9A ATG9A WDR45 WDR45 ULK1 ULK1 OTUD7B OTUD7B BECN1 BECN1 ATG7 ATG7 NBR1 NBR1 PIKFYVE PIKFYVE
"WDR45" - WD repeat domain 45 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
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large nodes:
some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
WDR45WD repeat domain 45 (361 aa)    
Predicted Functional Partners:
ATG2B
autophagy related 2B; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion (2078 aa)
        score_image   score_image   0.999
OTUD7B
OTU domain containing 7B; Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF- kappa-B stimuli, deubiquitinates ’Lys-48’-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections. Mediates deubiquitination of EGFR. Has deubiquitinating activity toward ’Lys-11’, ’Lys-48’ or ’Lys-63’- link [...] (843 aa)
            score_image   0.810
ATG2A
autophagy related 2A; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion (1938 aa)
        score_image   score_image   0.790
BECN1
beclin 1, autophagy related; Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus (450 aa)
        score_image   score_image   0.695
ATG9A
autophagy related 9A (839 aa)
            score_image   0.673
PIKFYVE
phosphoinositide kinase, FYVE finger containing; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo- inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes (2098 aa)
            score_image   0.626
ATG7
autophagy related 7; Functions as an E1 enzyme essential for multisubstrates such as ATG8-like proteins and ATG12. Forms intermediate conjugates with ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). PE-conjugation to ATG8-like proteins is essential for autophagy. Also acts as an E1 enzyme for ATG12 conjugation to ATG5 and ATG3 (By similarity) (703 aa)
        score_image   score_image   0.601
NBR1
neighbor of BRCA1 gene 1; Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets (966 aa)
            score_image   0.595
KBTBD7
kelch repeat and BTB (POZ) domain containing 7 (684 aa)
            score_image   0.527
ULK1
unc-51-like kinase 1 (C. elegans); Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy- acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading [...] (1050 aa)
            score_image   0.509
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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