node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CHPT1 | PLA2G10 | ENSP00000229266 | ENSP00000393847 | choline phosphotransferase 1 | phospholipase A2, group X; PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine | 0.902 |
CHPT1 | PLA2G12B | ENSP00000229266 | ENSP00000362123 | choline phosphotransferase 1 | phospholipase A2, group XIIB; Not known; does not seem to have catalytic activity | 0.911 |
CHPT1 | PLA2G1B | ENSP00000229266 | ENSP00000312286 | choline phosphotransferase 1 | phospholipase A2, group IB (pancreas); PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules | 0.906 |
CHPT1 | PLA2G2E | ENSP00000229266 | ENSP00000364257 | choline phosphotransferase 1 | phospholipase A2, group IIE; PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Has a preference for arachidonic-containing phospholipids | 0.910 |
CHPT1 | PLA2G4A | ENSP00000229266 | ENSP00000356436 | choline phosphotransferase 1 | phospholipase A2, group IVA (cytosolic, calcium-dependent); Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response | 0.917 |
CHPT1 | PLA2G4B | ENSP00000229266 | ENSP00000396045 | choline phosphotransferase 1 | phospholipase A2, group IVB (cytosolic); Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position with a preference for arachidonoyl phospholipids. Has a much weaker activity than PLA2G4A. Isoform 3 has calcium-dependent activity against palmitoyl-arachidonyl-phosphatidylethanolamine and low level lysophospholipase activity but no activity against phosphatidylcholine. Isoform 5 does have activity against phosphatidylcholine | 0.907 |
CHPT1 | PLA2G4C | ENSP00000229266 | ENSP00000400036 | choline phosphotransferase 1 | phospholipase A2, group IVC (cytosolic, calcium-independent); Has a preference for arachidonic acid at the sn-2 position of phosphatidylcholine as compared with palmitic acid | 0.904 |
CHPT1 | PLA2G6 | ENSP00000229266 | ENSP00000333142 | choline phosphotransferase 1 | phospholipase A2, group VI (cytosolic, calcium-independent); Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F- actin polymerization at the pse [...] | 0.907 |
CHPT1 | PLD3 | ENSP00000229266 | ENSP00000348901 | choline phosphotransferase 1 | phospholipase D family, member 3 | 0.907 |
PLA2G10 | CHPT1 | ENSP00000393847 | ENSP00000229266 | phospholipase A2, group X; PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine | choline phosphotransferase 1 | 0.902 |
PLA2G10 | PLA2G12B | ENSP00000393847 | ENSP00000362123 | phospholipase A2, group X; PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine | phospholipase A2, group XIIB; Not known; does not seem to have catalytic activity | 0.860 |
PLA2G10 | PLA2G4A | ENSP00000393847 | ENSP00000356436 | phospholipase A2, group X; PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine | phospholipase A2, group IVA (cytosolic, calcium-dependent); Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response | 0.552 |
PLA2G10 | PLA2G6 | ENSP00000393847 | ENSP00000333142 | phospholipase A2, group X; PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine | phospholipase A2, group VI (cytosolic, calcium-independent); Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F- actin polymerization at the pse [...] | 0.815 |
PLA2G10 | PLD3 | ENSP00000393847 | ENSP00000348901 | phospholipase A2, group X; PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine | phospholipase D family, member 3 | 0.909 |
PLA2G12B | CHPT1 | ENSP00000362123 | ENSP00000229266 | phospholipase A2, group XIIB; Not known; does not seem to have catalytic activity | choline phosphotransferase 1 | 0.911 |
PLA2G12B | PLA2G10 | ENSP00000362123 | ENSP00000393847 | phospholipase A2, group XIIB; Not known; does not seem to have catalytic activity | phospholipase A2, group X; PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine | 0.860 |
PLA2G12B | PLA2G1B | ENSP00000362123 | ENSP00000312286 | phospholipase A2, group XIIB; Not known; does not seem to have catalytic activity | phospholipase A2, group IB (pancreas); PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules | 0.439 |
PLA2G12B | PLA2G2E | ENSP00000362123 | ENSP00000364257 | phospholipase A2, group XIIB; Not known; does not seem to have catalytic activity | phospholipase A2, group IIE; PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Has a preference for arachidonic-containing phospholipids | 0.566 |
PLA2G12B | PLD3 | ENSP00000362123 | ENSP00000348901 | phospholipase A2, group XIIB; Not known; does not seem to have catalytic activity | phospholipase D family, member 3 | 0.916 |
PLA2G1B | CHPT1 | ENSP00000312286 | ENSP00000229266 | phospholipase A2, group IB (pancreas); PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules | choline phosphotransferase 1 | 0.906 |