node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADAM33 | CDH11 | ENSP00000348912 | ENSP00000268603 | ADAM metallopeptidase domain 33 | cadherin 11, type 2, OB-cadherin (osteoblast); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types | 0.590 |
ADAM33 | CDH8 | ENSP00000348912 | ENSP00000462701 | ADAM metallopeptidase domain 33 | cadherin 8, type 2; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types | 0.590 |
ADAM33 | DPP10 | ENSP00000348912 | ENSP00000376855 | ADAM metallopeptidase domain 33 | dipeptidyl-peptidase 10 (non-functional) | 0.778 |
ADAM33 | FIGF | ENSP00000348912 | ENSP00000297904 | ADAM metallopeptidase domain 33 | c-fos induced growth factor (vascular endothelial growth factor D); Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors | 0.820 |
ADAM33 | MS4A2 | ENSP00000348912 | ENSP00000278888 | ADAM metallopeptidase domain 33 | membrane-spanning 4-domains, subfamily A, member 2; High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy | 0.567 |
ADAM33 | NPSR1 | ENSP00000348912 | ENSP00000352839 | ADAM metallopeptidase domain 33 | neuropeptide S receptor 1 | 0.779 |
ADAM33 | ORMDL3 | ENSP00000348912 | ENSP00000304858 | ADAM metallopeptidase domain 33 | ORM1-like 3 (S. cerevisiae); Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling | 0.635 |
ADAM33 | PHF11 | ENSP00000348912 | ENSP00000367570 | ADAM metallopeptidase domain 33 | PHD finger protein 11; Positive regulator of Th1-type cytokine gene expression | 0.726 |
ADAM33 | SKIL | ENSP00000348912 | ENSP00000259119 | ADAM metallopeptidase domain 33 | SKI-like oncogene; May have regulatory role in cell division or differentiation in response to extracellular signals | 0.614 |
ADAM33 | SLC30A2 | ENSP00000348912 | ENSP00000363394 | ADAM metallopeptidase domain 33 | solute carrier family 30 (zinc transporter), member 2 | 0.609 |
CDH11 | ADAM33 | ENSP00000268603 | ENSP00000348912 | cadherin 11, type 2, OB-cadherin (osteoblast); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types | ADAM metallopeptidase domain 33 | 0.590 |
CDH11 | CDH8 | ENSP00000268603 | ENSP00000462701 | cadherin 11, type 2, OB-cadherin (osteoblast); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types | cadherin 8, type 2; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types | 0.902 |
CDH8 | ADAM33 | ENSP00000462701 | ENSP00000348912 | cadherin 8, type 2; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types | ADAM metallopeptidase domain 33 | 0.590 |
CDH8 | CDH11 | ENSP00000462701 | ENSP00000268603 | cadherin 8, type 2; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types | cadherin 11, type 2, OB-cadherin (osteoblast); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types | 0.902 |
DPP10 | ADAM33 | ENSP00000376855 | ENSP00000348912 | dipeptidyl-peptidase 10 (non-functional) | ADAM metallopeptidase domain 33 | 0.778 |
DPP10 | NPSR1 | ENSP00000376855 | ENSP00000352839 | dipeptidyl-peptidase 10 (non-functional) | neuropeptide S receptor 1 | 0.757 |
DPP10 | ORMDL3 | ENSP00000376855 | ENSP00000304858 | dipeptidyl-peptidase 10 (non-functional) | ORM1-like 3 (S. cerevisiae); Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling | 0.589 |
DPP10 | PHF11 | ENSP00000376855 | ENSP00000367570 | dipeptidyl-peptidase 10 (non-functional) | PHD finger protein 11; Positive regulator of Th1-type cytokine gene expression | 0.770 |
FIGF | ADAM33 | ENSP00000297904 | ENSP00000348912 | c-fos induced growth factor (vascular endothelial growth factor D); Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors | ADAM metallopeptidase domain 33 | 0.820 |
MS4A2 | ADAM33 | ENSP00000278888 | ENSP00000348912 | membrane-spanning 4-domains, subfamily A, member 2; High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy | ADAM metallopeptidase domain 33 | 0.567 |