CBWD1 protein (Homo sapiens) - STRING network view

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CBWD1

COBW domain containing 1 (395 aa)

Predicted Functional Partners:

UBC

0.721

SETD2

0.574

METAP1

0.540

SLC30A5

0.528

KANK1

0.508

FOXD4L5

0.499

SLC30A10

0.451

DOCK8

0.448

OSGEPL1

0.418

PSMC6

0.413

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBWD1	DOCK8	ENSP00000348915	ENSP00000408464	COBW domain containing 1	dedicator of cytokinesis 8	0.448
CBWD1	FOXD4L5	ENSP00000348915	ENSP00000366637	COBW domain containing 1	forkhead box D4-like 5	0.499
CBWD1	KANK1	ENSP00000348915	ENSP00000371734	COBW domain containing 1	KN motif and ankyrin repeat domains 1; Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration. Inhibits RhoA activity; the function involves phosphorylation through PI3K/Akt signaling and may depend on the competetive interaction with 14-3-3 adapter proteins to sequester them from active complexes. Inhibits the formation of lamellipodia but not of filopodia; the function may depend on the competetive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell sp [...]	0.508
CBWD1	METAP1	ENSP00000348915	ENSP00000296411	COBW domain containing 1	methionyl aminopeptidase 1; Removes the N-terminal methionine from nascent proteins. Required for normal progression through the cell cycle	0.540
CBWD1	OSGEPL1	ENSP00000348915	ENSP00000264151	COBW domain containing 1	O-sialoglycoprotein endopeptidase-like 1; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)	0.418
CBWD1	PSMC6	ENSP00000348915	ENSP00000401802	COBW domain containing 1	proteasome (prosome, macropain) 26S subunit, ATPase, 6; The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex	0.413
CBWD1	SETD2	ENSP00000348915	ENSP00000386759	COBW domain containing 1	SET domain containing 2	0.574
CBWD1	SLC30A10	ENSP00000348915	ENSP00000355893	COBW domain containing 1	solute carrier family 30, member 10; May be involved in zinc transport out of the cell, being a zinc-efflux transporter (By similarity)	0.451
CBWD1	SLC30A5	ENSP00000348915	ENSP00000379836	COBW domain containing 1	solute carrier family 30 (zinc transporter), member 5; Functions as a zinc transporter. May be a transporter of zinc into beta cells in order to form insulin crystals. Partly regulates cellular zinc homeostasis. Required with ZNT7 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT6 and ZNT7 for the activation of TNAP	0.528
CBWD1	UBC	ENSP00000348915	ENSP00000344818	COBW domain containing 1	ubiquitin C	0.721
DOCK8	CBWD1	ENSP00000408464	ENSP00000348915	dedicator of cytokinesis 8	COBW domain containing 1	0.448
DOCK8	KANK1	ENSP00000408464	ENSP00000371734	dedicator of cytokinesis 8	KN motif and ankyrin repeat domains 1; Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration. Inhibits RhoA activity; the function involves phosphorylation through PI3K/Akt signaling and may depend on the competetive interaction with 14-3-3 adapter proteins to sequester them from active complexes. Inhibits the formation of lamellipodia but not of filopodia; the function may depend on the competetive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell sp [...]	0.860
FOXD4L5	CBWD1	ENSP00000366637	ENSP00000348915	forkhead box D4-like 5	COBW domain containing 1	0.499
KANK1	CBWD1	ENSP00000371734	ENSP00000348915	KN motif and ankyrin repeat domains 1; Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration. Inhibits RhoA activity; the function involves phosphorylation through PI3K/Akt signaling and may depend on the competetive interaction with 14-3-3 adapter proteins to sequester them from active complexes. Inhibits the formation of lamellipodia but not of filopodia; the function may depend on the competetive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell sp [...]	COBW domain containing 1	0.508
KANK1	DOCK8	ENSP00000371734	ENSP00000408464	KN motif and ankyrin repeat domains 1; Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration. Inhibits RhoA activity; the function involves phosphorylation through PI3K/Akt signaling and may depend on the competetive interaction with 14-3-3 adapter proteins to sequester them from active complexes. Inhibits the formation of lamellipodia but not of filopodia; the function may depend on the competetive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell sp [...]	dedicator of cytokinesis 8	0.860
METAP1	CBWD1	ENSP00000296411	ENSP00000348915	methionyl aminopeptidase 1; Removes the N-terminal methionine from nascent proteins. Required for normal progression through the cell cycle	COBW domain containing 1	0.540
METAP1	UBC	ENSP00000296411	ENSP00000344818	methionyl aminopeptidase 1; Removes the N-terminal methionine from nascent proteins. Required for normal progression through the cell cycle	ubiquitin C	0.707
OSGEPL1	CBWD1	ENSP00000264151	ENSP00000348915	O-sialoglycoprotein endopeptidase-like 1; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)	COBW domain containing 1	0.418
PSMC6	CBWD1	ENSP00000401802	ENSP00000348915	proteasome (prosome, macropain) 26S subunit, ATPase, 6; The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex	COBW domain containing 1	0.413
PSMC6	UBC	ENSP00000401802	ENSP00000344818	proteasome (prosome, macropain) 26S subunit, ATPase, 6; The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex	ubiquitin C	0.999

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