Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | MEGF6 | multiple EGF-like-domains 6 (1541 aa) | ||||||||||||
Predicted Functional Partners:
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 | WRAP73 | WD repeat containing, antisense to TP73 (460 aa) |
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0.814 | ||||||||||
 | ZBTB40 | zinc finger and BTB domain containing 40; May be involved in transcriptional regulation (1239 aa) |
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0.756 | |||||||||
 | EMILIN1 | elastin microfibril interfacer 1; May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vessel assembly. Has cell adhesive capacity (1016 aa) |
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0.756 | ||||||||||
 | GULP1 | GULP, engulfment adaptor PTB domain containing 1 (304 aa) |
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0.737 | |||||||||
 | ARMC5 | armadillo repeat containing 5 (935 aa) |
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0.671 | ||||||||||
 | MFAP5 | microfibrillar associated protein 5; Component of the elastin-associated microfibrils (173 aa) |
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0.662 | |||||||||
 | C1QTNF1 | C1q and tumor necrosis factor related protein 1 (281 aa) |
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0.640 | ||||||||||
 | ANGPTL1 | angiopoietin-like 1 (491 aa) |
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0.626 | ||||||||||
 | RSPO1 | R-spondin 1; Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination (263 aa) |
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0.621 | |||||||||
 | LRRC17 | leucine rich repeat containing 17; Involved in bone homeostasis. Acts as a negative regulator of RANKL-induced osteoclast precursor differentiation from bone marrow precursors (By similarity) (441 aa) |
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0.619 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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