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BDNF BDNF DLG4 DLG4 UBE3A UBE3A SPTAN1 SPTAN1 UBC UBC KRT15 KRT15 ARC ARC SIRPA SIRPA NRGN NRGN NOL3 NOL3 ETNK2 ETNK2
"ARC" - activity-regulated cytoskeleton-associated protein in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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Predicted Interactions
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ARCactivity-regulated cytoskeleton-associated protein; Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration (396 aa)    
Predicted Functional Partners:
NOL3
nucleolar protein 3 (apoptosis repressor with CARD domain); Isoform 1 may be involved in RNA splicing (208 aa)
        score_image   score_image   0.875
UBE3A
ubiquitin protein ligase E3A (875 aa)
        score_image   score_image   0.731
ETNK2
ethanolamine kinase 2; Highly specific for ethanolamine phosphorylation. Does not have choline kinase activity (By similarity) (386 aa)
        score_image       0.692
SIRPA
signal-regulatory protein alpha (504 aa)
        score_image       0.692
UBC
ubiquitin C (685 aa)
        score_image       0.681
NRGN
neurogranin (protein kinase C substrate, RC3); Acts as a "third messenger" substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity) (78 aa)
            score_image   0.641
DLG4
discs, large homolog 4 (Drosophila); Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity) (767 aa)
        score_image   score_image   0.637
BDNF
brain-derived neurotrophic factor (329 aa)
            score_image   0.634
KRT15
keratin 15 (456 aa)
        score_image       0.633
SPTAN1
spectrin, alpha, non-erythrocytic 1 (2477 aa)
            score_image   0.585
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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