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MYL7 MYL7 MYL10 MYL10 CDC42BPB CDC42BPB MYLPF MYLPF MYL2 MYL2 MYL5 MYL5 MYL9 MYL9 NRARP NRARP MYL12B MYL12B RBPJ RBPJ NOTCH1 NOTCH1
"NRARP" - NOTCH-regulated ankyrin repeat protein in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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Score
NRARPNOTCH-regulated ankyrin repeat protein; May play a role in the formation of somites (By similarity) (114 aa)    
Predicted Functional Partners:
CDC42BPB
CDC42 binding protein kinase beta (DMPK-like); Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A (1711 aa)
        score_image   score_image   0.794
NOTCH1
notch 1; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ c [...] (2555 aa)
            score_image   0.649
RBPJ
recombination signal binding protein for immunoglobulin kappa J region; Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of c [...] (500 aa)
      score_image score_image   score_image   0.638
MYL5
myosin, light chain 5, regulatory (173 aa)
        score_image   score_image   0.612
MYLPF
myosin light chain, phosphorylatable, fast skeletal muscle (169 aa)
        score_image   score_image   0.612
MYL9
myosin, light chain 9, regulatory; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (172 aa)
        score_image   score_image   0.612
MYL12B
myosin, light chain 12B, regulatory; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity) (172 aa)
        score_image   score_image   0.612
MYL2
myosin, light chain 2, regulatory, cardiac, slow (166 aa)
        score_image   score_image   0.612
MYL7
myosin, light chain 7, regulatory (175 aa)
        score_image   score_image   0.612
MYL10
myosin, light chain 10, regulatory (226 aa)
        score_image   score_image   0.612
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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