ZNF74 protein (Homo sapiens) - STRING network view

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ZNF74

zinc finger protein 74 (644 aa)

Predicted Functional Partners:

POLR2A

0.812

ZNF69

0.811

MED15

0.680

DGCR2

0.664

DGCR6

0.662

TRIM28

0.618

ALX3

0.583

C22orf39

0.564

XRN1

0.543

SCARF2

0.525

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALX3	ZNF74	ENSP00000358807	ENSP00000349098	ALX homeobox 3; Transcriptional regulator with a possible role in patterning of mesoderm during development (By similarity)	zinc finger protein 74	0.583
C22orf39	ZNF74	ENSP00000333064	ENSP00000349098	chromosome 22 open reading frame 39	zinc finger protein 74	0.564
DGCR2	DGCR6	ENSP00000263196	ENSP00000331681	DiGeorge syndrome critical region gene 2; Putative adhesion receptor, that could be involved in cell-cell or cell-matrix interactions required for normal cell differentiation and migration	DiGeorge syndrome critical region gene 6; May play a role in neural crest cell migration into the third and fourth pharyngeal pouches	0.668
DGCR2	ZNF74	ENSP00000263196	ENSP00000349098	DiGeorge syndrome critical region gene 2; Putative adhesion receptor, that could be involved in cell-cell or cell-matrix interactions required for normal cell differentiation and migration	zinc finger protein 74	0.664
DGCR6	DGCR2	ENSP00000331681	ENSP00000263196	DiGeorge syndrome critical region gene 6; May play a role in neural crest cell migration into the third and fourth pharyngeal pouches	DiGeorge syndrome critical region gene 2; Putative adhesion receptor, that could be involved in cell-cell or cell-matrix interactions required for normal cell differentiation and migration	0.668
DGCR6	ZNF74	ENSP00000331681	ENSP00000349098	DiGeorge syndrome critical region gene 6; May play a role in neural crest cell migration into the third and fourth pharyngeal pouches	zinc finger protein 74	0.662
MED15	ZNF74	ENSP00000263205	ENSP00000349098	mediator complex subunit 15	zinc finger protein 74	0.680
POLR2A	XRN1	ENSP00000314949	ENSP00000264951	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the cen [...]	5’-3’ exoribonuclease 1; Major 5’-3’ exoribonuclease involved in mRNA decay. Required for the 5’-3’-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS)	0.506
POLR2A	ZNF74	ENSP00000314949	ENSP00000349098	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the cen [...]	zinc finger protein 74	0.812
SCARF2	ZNF74	ENSP00000266214	ENSP00000349098	scavenger receptor class F, member 2; Probable adhesion protein, which mediates homophilic and heterophilic interactions. In contrast to SCARF1, it poorly mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL) (By similarity)	zinc finger protein 74	0.525
TRIM28	ZNF74	ENSP00000253024	ENSP00000349098	tripartite motif containing 28; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitm [...]	zinc finger protein 74	0.618
XRN1	POLR2A	ENSP00000264951	ENSP00000314949	5’-3’ exoribonuclease 1; Major 5’-3’ exoribonuclease involved in mRNA decay. Required for the 5’-3’-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS)	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the cen [...]	0.506
XRN1	ZNF69	ENSP00000264951	ENSP00000345333	5’-3’ exoribonuclease 1; Major 5’-3’ exoribonuclease involved in mRNA decay. Required for the 5’-3’-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS)	zinc finger protein 69; May be involved in transcriptional regulation	0.543
XRN1	ZNF74	ENSP00000264951	ENSP00000349098	5’-3’ exoribonuclease 1; Major 5’-3’ exoribonuclease involved in mRNA decay. Required for the 5’-3’-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS)	zinc finger protein 74	0.543
ZNF69	XRN1	ENSP00000345333	ENSP00000264951	zinc finger protein 69; May be involved in transcriptional regulation	5’-3’ exoribonuclease 1; Major 5’-3’ exoribonuclease involved in mRNA decay. Required for the 5’-3’-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS)	0.543
ZNF69	ZNF74	ENSP00000345333	ENSP00000349098	zinc finger protein 69; May be involved in transcriptional regulation	zinc finger protein 74	0.811
ZNF74	ALX3	ENSP00000349098	ENSP00000358807	zinc finger protein 74	ALX homeobox 3; Transcriptional regulator with a possible role in patterning of mesoderm during development (By similarity)	0.583
ZNF74	C22orf39	ENSP00000349098	ENSP00000333064	zinc finger protein 74	chromosome 22 open reading frame 39	0.564
ZNF74	DGCR2	ENSP00000349098	ENSP00000263196	zinc finger protein 74	DiGeorge syndrome critical region gene 2; Putative adhesion receptor, that could be involved in cell-cell or cell-matrix interactions required for normal cell differentiation and migration	0.664
ZNF74	DGCR6	ENSP00000349098	ENSP00000331681	zinc finger protein 74	DiGeorge syndrome critical region gene 6; May play a role in neural crest cell migration into the third and fourth pharyngeal pouches	0.662

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