RSPO3 protein (Homo sapiens) - STRING network view

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RSPO3

R-spondin 3; Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway (By similarity) (272 aa)

Predicted Functional Partners:

LGR4

0.980

RSPO1

0.957

ZNRF3

0.956

LGR5

0.945

LGR6

0.939

RSPO4

0.908

FZD8

0.908

RSPO2

0.905

UBA52

0.904

UBC

0.904

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FZD8	RSPO1	ENSP00000363826	ENSP00000348944	frizzled family receptor 8; Receptor for Wnt proteins. Component of the Wnt-Fzd- LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome- sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it [...]	R-spondin 1; Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination	0.876
FZD8	RSPO3	ENSP00000363826	ENSP00000349131	frizzled family receptor 8; Receptor for Wnt proteins. Component of the Wnt-Fzd- LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome- sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it [...]	R-spondin 3; Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway (By similarity)	0.908
LGR4	LGR5	ENSP00000368516	ENSP00000266674	leucine-rich repeat containing G protein-coupled receptor 4; Orphan receptor	leucine-rich repeat containing G protein-coupled receptor 5; Orphan receptor. Stem cell marker of the intestinal epithelium and the hair follicle. Target gene of Wnt signaling	0.905
LGR4	LGR6	ENSP00000368516	ENSP00000356247	leucine-rich repeat containing G protein-coupled receptor 4; Orphan receptor	leucine-rich repeat containing G protein-coupled receptor 6; Orphan receptor	0.906
LGR4	RSPO1	ENSP00000368516	ENSP00000348944	leucine-rich repeat containing G protein-coupled receptor 4; Orphan receptor	R-spondin 1; Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination	0.999
LGR4	RSPO2	ENSP00000368516	ENSP00000276659	leucine-rich repeat containing G protein-coupled receptor 4; Orphan receptor	R-spondin 2; Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a ligand for frizzled and LRP receptors (By similarity)	0.976
LGR4	RSPO3	ENSP00000368516	ENSP00000349131	leucine-rich repeat containing G protein-coupled receptor 4; Orphan receptor	R-spondin 3; Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway (By similarity)	0.980
LGR4	RSPO4	ENSP00000368516	ENSP00000217260	leucine-rich repeat containing G protein-coupled receptor 4; Orphan receptor	R-spondin 4; Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway (By similarity)	0.978
LGR4	UBA52	ENSP00000368516	ENSP00000388107	leucine-rich repeat containing G protein-coupled receptor 4; Orphan receptor	ubiquitin A-52 residue ribosomal protein fusion product 1	0.912
LGR4	UBC	ENSP00000368516	ENSP00000344818	leucine-rich repeat containing G protein-coupled receptor 4; Orphan receptor	ubiquitin C	0.955
LGR4	ZNRF3	ENSP00000368516	ENSP00000443824	leucine-rich repeat containing G protein-coupled receptor 4; Orphan receptor	zinc and ring finger 3; E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non- canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone	0.995
LGR5	LGR4	ENSP00000266674	ENSP00000368516	leucine-rich repeat containing G protein-coupled receptor 5; Orphan receptor. Stem cell marker of the intestinal epithelium and the hair follicle. Target gene of Wnt signaling	leucine-rich repeat containing G protein-coupled receptor 4; Orphan receptor	0.905
LGR5	LGR6	ENSP00000266674	ENSP00000356247	leucine-rich repeat containing G protein-coupled receptor 5; Orphan receptor. Stem cell marker of the intestinal epithelium and the hair follicle. Target gene of Wnt signaling	leucine-rich repeat containing G protein-coupled receptor 6; Orphan receptor	0.902
LGR5	RSPO1	ENSP00000266674	ENSP00000348944	leucine-rich repeat containing G protein-coupled receptor 5; Orphan receptor. Stem cell marker of the intestinal epithelium and the hair follicle. Target gene of Wnt signaling	R-spondin 1; Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination	0.997
LGR5	RSPO2	ENSP00000266674	ENSP00000276659	leucine-rich repeat containing G protein-coupled receptor 5; Orphan receptor. Stem cell marker of the intestinal epithelium and the hair follicle. Target gene of Wnt signaling	R-spondin 2; Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a ligand for frizzled and LRP receptors (By similarity)	0.988
LGR5	RSPO3	ENSP00000266674	ENSP00000349131	leucine-rich repeat containing G protein-coupled receptor 5; Orphan receptor. Stem cell marker of the intestinal epithelium and the hair follicle. Target gene of Wnt signaling	R-spondin 3; Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway (By similarity)	0.945
LGR5	RSPO4	ENSP00000266674	ENSP00000217260	leucine-rich repeat containing G protein-coupled receptor 5; Orphan receptor. Stem cell marker of the intestinal epithelium and the hair follicle. Target gene of Wnt signaling	R-spondin 4; Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway (By similarity)	0.943
LGR5	UBA52	ENSP00000266674	ENSP00000388107	leucine-rich repeat containing G protein-coupled receptor 5; Orphan receptor. Stem cell marker of the intestinal epithelium and the hair follicle. Target gene of Wnt signaling	ubiquitin A-52 residue ribosomal protein fusion product 1	0.912
LGR5	UBC	ENSP00000266674	ENSP00000344818	leucine-rich repeat containing G protein-coupled receptor 5; Orphan receptor. Stem cell marker of the intestinal epithelium and the hair follicle. Target gene of Wnt signaling	ubiquitin C	0.919
LGR5	ZNRF3	ENSP00000266674	ENSP00000443824	leucine-rich repeat containing G protein-coupled receptor 5; Orphan receptor. Stem cell marker of the intestinal epithelium and the hair follicle. Target gene of Wnt signaling	zinc and ring finger 3; E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non- canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone	0.946

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