HBM protein (Homo sapiens) - STRING network view

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Score

HBM

hemoglobin, mu (141 aa)

Predicted Functional Partners:

SOCS2

0.659

APRT

0.606

KLF1

0.583

SOST

0.564

CAPRIN2

0.564

AIFM3

0.562

HP

0.510

R3HDM4

0.472

SCN2A

0.459

CYB5R3

0.456

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIFM3	HBM	ENSP00000382120	ENSP00000349270	apoptosis-inducing factor, mitochondrion-associated, 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential	hemoglobin, mu	0.562
APRT	HBM	ENSP00000367615	ENSP00000349270	adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	hemoglobin, mu	0.606
APRT	HP	ENSP00000367615	ENSP00000348170	adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	haptoglobin; As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation [...]	0.454
CAPRIN2	HBM	ENSP00000298892	ENSP00000349270	caprin family member 2	hemoglobin, mu	0.564
CYB5R3	HBM	ENSP00000354468	ENSP00000349270	cytochrome b5 reductase 3	hemoglobin, mu	0.456
HBM	AIFM3	ENSP00000349270	ENSP00000382120	hemoglobin, mu	apoptosis-inducing factor, mitochondrion-associated, 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential	0.562
HBM	APRT	ENSP00000349270	ENSP00000367615	hemoglobin, mu	adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	0.606
HBM	CAPRIN2	ENSP00000349270	ENSP00000298892	hemoglobin, mu	caprin family member 2	0.564
HBM	CYB5R3	ENSP00000349270	ENSP00000354468	hemoglobin, mu	cytochrome b5 reductase 3	0.456
HBM	HP	ENSP00000349270	ENSP00000348170	hemoglobin, mu	haptoglobin; As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation [...]	0.510
HBM	KLF1	ENSP00000349270	ENSP00000264834	hemoglobin, mu	Kruppel-like factor 1 (erythroid); Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, a [...]	0.583
HBM	R3HDM4	ENSP00000349270	ENSP00000355385	hemoglobin, mu	R3H domain containing 4	0.472
HBM	SCN2A	ENSP00000349270	ENSP00000283256	hemoglobin, mu	sodium channel, voltage-gated, type II, alpha subunit; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient	0.459
HBM	SOCS2	ENSP00000349270	ENSP00000339428	hemoglobin, mu	suppressor of cytokine signaling 2; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins	0.659
HBM	SOST	ENSP00000349270	ENSP00000301691	hemoglobin, mu	sclerostin; Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation	0.564
HP	APRT	ENSP00000348170	ENSP00000367615	haptoglobin; As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation [...]	adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	0.454
HP	HBM	ENSP00000348170	ENSP00000349270	haptoglobin; As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation [...]	hemoglobin, mu	0.510
KLF1	HBM	ENSP00000264834	ENSP00000349270	Kruppel-like factor 1 (erythroid); Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, a [...]	hemoglobin, mu	0.583
KLF1	SCN2A	ENSP00000264834	ENSP00000283256	Kruppel-like factor 1 (erythroid); Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, a [...]	sodium channel, voltage-gated, type II, alpha subunit; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient	0.511
R3HDM4	HBM	ENSP00000355385	ENSP00000349270	R3H domain containing 4	hemoglobin, mu	0.472

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