PPP1R26 protein (Homo sapiens) - STRING network view

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PPP1R26

protein phosphatase 1, regulatory subunit 26; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. May positively regulate cell proliferation (1209 aa)

Predicted Functional Partners:

UTP20

0.795

OR2S2

0.581

C7orf50

0.540

C4orf19

0.509

HINFP

0.487

RFC1

0.457

ESD

0.440

RB1CC1

0.439

RGCC

0.418

BTBD9

0.410

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BTBD9	PPP1R26	ENSP00000386121	ENSP00000349274	BTB (POZ) domain containing 9	protein phosphatase 1, regulatory subunit 26; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. May positively regulate cell proliferation	0.410
C4orf19	OR2S2	ENSP00000284437	ENSP00000344040	chromosome 4 open reading frame 19	olfactory receptor, family 2, subfamily S, member 2; Odorant receptor (Potential)	0.583
C4orf19	PPP1R26	ENSP00000284437	ENSP00000349274	chromosome 4 open reading frame 19	protein phosphatase 1, regulatory subunit 26; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. May positively regulate cell proliferation	0.509
C7orf50	PPP1R26	ENSP00000350011	ENSP00000349274	chromosome 7 open reading frame 50	protein phosphatase 1, regulatory subunit 26; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. May positively regulate cell proliferation	0.540
ESD	HINFP	ENSP00000367992	ENSP00000318085	esterase D; Serine hydrolase involved in the detoxification of formaldehyde	histone H4 transcription factor; Transcriptional repressor that binds to the consensus sequence 5’-CGGACGTT-3’ and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter	0.439
ESD	PPP1R26	ENSP00000367992	ENSP00000349274	esterase D; Serine hydrolase involved in the detoxification of formaldehyde	protein phosphatase 1, regulatory subunit 26; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. May positively regulate cell proliferation	0.440
ESD	RFC1	ENSP00000367992	ENSP00000371321	esterase D; Serine hydrolase involved in the detoxification of formaldehyde	replication factor C (activator 1) 1, 145kDa; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Could play a role in DNA transcription regulation as well as DNA replication and/or repair. Can bind single- or double-stranded DNA	0.402
HINFP	ESD	ENSP00000318085	ENSP00000367992	histone H4 transcription factor; Transcriptional repressor that binds to the consensus sequence 5’-CGGACGTT-3’ and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter	esterase D; Serine hydrolase involved in the detoxification of formaldehyde	0.439
HINFP	PPP1R26	ENSP00000318085	ENSP00000349274	histone H4 transcription factor; Transcriptional repressor that binds to the consensus sequence 5’-CGGACGTT-3’ and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter	protein phosphatase 1, regulatory subunit 26; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. May positively regulate cell proliferation	0.487
HINFP	RB1CC1	ENSP00000318085	ENSP00000025008	histone H4 transcription factor; Transcriptional repressor that binds to the consensus sequence 5’-CGGACGTT-3’ and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter	RB1-inducible coiled-coil 1; Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111. Involved in autophagy. Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1. Required for the formation of the autophagosome-like double- membrane structure that surrounds the Salmonella-containing vacuole (SCV) duting S.typhimurium infection and subsequent xenophagy. Autophagy positively regulates repair of DNA damage induced by ionizing radiation and negatively regulates apoptosis. Plays an indispensib [...]	0.405
HINFP	RFC1	ENSP00000318085	ENSP00000371321	histone H4 transcription factor; Transcriptional repressor that binds to the consensus sequence 5’-CGGACGTT-3’ and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter	replication factor C (activator 1) 1, 145kDa; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Could play a role in DNA transcription regulation as well as DNA replication and/or repair. Can bind single- or double-stranded DNA	0.440
HINFP	RGCC	ENSP00000318085	ENSP00000368664	histone H4 transcription factor; Transcriptional repressor that binds to the consensus sequence 5’-CGGACGTT-3’ and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter	regulator of cell cycle; Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at the G2/M transition. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation	0.400
OR2S2	C4orf19	ENSP00000344040	ENSP00000284437	olfactory receptor, family 2, subfamily S, member 2; Odorant receptor (Potential)	chromosome 4 open reading frame 19	0.583
OR2S2	PPP1R26	ENSP00000344040	ENSP00000349274	olfactory receptor, family 2, subfamily S, member 2; Odorant receptor (Potential)	protein phosphatase 1, regulatory subunit 26; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. May positively regulate cell proliferation	0.581
PPP1R26	BTBD9	ENSP00000349274	ENSP00000386121	protein phosphatase 1, regulatory subunit 26; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. May positively regulate cell proliferation	BTB (POZ) domain containing 9	0.410
PPP1R26	C4orf19	ENSP00000349274	ENSP00000284437	protein phosphatase 1, regulatory subunit 26; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. May positively regulate cell proliferation	chromosome 4 open reading frame 19	0.509
PPP1R26	C7orf50	ENSP00000349274	ENSP00000350011	protein phosphatase 1, regulatory subunit 26; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. May positively regulate cell proliferation	chromosome 7 open reading frame 50	0.540
PPP1R26	ESD	ENSP00000349274	ENSP00000367992	protein phosphatase 1, regulatory subunit 26; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. May positively regulate cell proliferation	esterase D; Serine hydrolase involved in the detoxification of formaldehyde	0.440
PPP1R26	HINFP	ENSP00000349274	ENSP00000318085	protein phosphatase 1, regulatory subunit 26; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. May positively regulate cell proliferation	histone H4 transcription factor; Transcriptional repressor that binds to the consensus sequence 5’-CGGACGTT-3’ and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter	0.487
PPP1R26	OR2S2	ENSP00000349274	ENSP00000344040	protein phosphatase 1, regulatory subunit 26; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. May positively regulate cell proliferation	olfactory receptor, family 2, subfamily S, member 2; Odorant receptor (Potential)	0.581

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