node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BTBD9 | PPP1R26 | ENSP00000386121 | ENSP00000349274 | BTB (POZ) domain containing 9 | protein phosphatase 1, regulatory subunit 26; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. May positively regulate cell proliferation | 0.410 |
C4orf19 | OR2S2 | ENSP00000284437 | ENSP00000344040 | chromosome 4 open reading frame 19 | olfactory receptor, family 2, subfamily S, member 2; Odorant receptor (Potential) | 0.583 |
C4orf19 | PPP1R26 | ENSP00000284437 | ENSP00000349274 | chromosome 4 open reading frame 19 | protein phosphatase 1, regulatory subunit 26; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. May positively regulate cell proliferation | 0.509 |
C7orf50 | PPP1R26 | ENSP00000350011 | ENSP00000349274 | chromosome 7 open reading frame 50 | protein phosphatase 1, regulatory subunit 26; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. May positively regulate cell proliferation | 0.540 |
ESD | HINFP | ENSP00000367992 | ENSP00000318085 | esterase D; Serine hydrolase involved in the detoxification of formaldehyde | histone H4 transcription factor; Transcriptional repressor that binds to the consensus sequence 5’-CGGACGTT-3’ and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter | 0.439 |
ESD | PPP1R26 | ENSP00000367992 | ENSP00000349274 | esterase D; Serine hydrolase involved in the detoxification of formaldehyde | protein phosphatase 1, regulatory subunit 26; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. May positively regulate cell proliferation | 0.440 |
ESD | RFC1 | ENSP00000367992 | ENSP00000371321 | esterase D; Serine hydrolase involved in the detoxification of formaldehyde | replication factor C (activator 1) 1, 145kDa; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Could play a role in DNA transcription regulation as well as DNA replication and/or repair. Can bind single- or double-stranded DNA | 0.402 |
HINFP | ESD | ENSP00000318085 | ENSP00000367992 | histone H4 transcription factor; Transcriptional repressor that binds to the consensus sequence 5’-CGGACGTT-3’ and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter | esterase D; Serine hydrolase involved in the detoxification of formaldehyde | 0.439 |
HINFP | PPP1R26 | ENSP00000318085 | ENSP00000349274 | histone H4 transcription factor; Transcriptional repressor that binds to the consensus sequence 5’-CGGACGTT-3’ and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter | protein phosphatase 1, regulatory subunit 26; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. May positively regulate cell proliferation | 0.487 |
HINFP | RB1CC1 | ENSP00000318085 | ENSP00000025008 | histone H4 transcription factor; Transcriptional repressor that binds to the consensus sequence 5’-CGGACGTT-3’ and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter | RB1-inducible coiled-coil 1; Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111. Involved in autophagy. Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1. Required for the formation of the autophagosome-like double- membrane structure that surrounds the Salmonella-containing vacuole (SCV) duting S.typhimurium infection and subsequent xenophagy. Autophagy positively regulates repair of DNA damage induced by ionizing radiation and negatively regulates apoptosis. Plays an indispensib [...] | 0.405 |
HINFP | RFC1 | ENSP00000318085 | ENSP00000371321 | histone H4 transcription factor; Transcriptional repressor that binds to the consensus sequence 5’-CGGACGTT-3’ and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter | replication factor C (activator 1) 1, 145kDa; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Could play a role in DNA transcription regulation as well as DNA replication and/or repair. Can bind single- or double-stranded DNA | 0.440 |
HINFP | RGCC | ENSP00000318085 | ENSP00000368664 | histone H4 transcription factor; Transcriptional repressor that binds to the consensus sequence 5’-CGGACGTT-3’ and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter | regulator of cell cycle; Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at the G2/M transition. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation | 0.400 |
OR2S2 | C4orf19 | ENSP00000344040 | ENSP00000284437 | olfactory receptor, family 2, subfamily S, member 2; Odorant receptor (Potential) | chromosome 4 open reading frame 19 | 0.583 |
OR2S2 | PPP1R26 | ENSP00000344040 | ENSP00000349274 | olfactory receptor, family 2, subfamily S, member 2; Odorant receptor (Potential) | protein phosphatase 1, regulatory subunit 26; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. May positively regulate cell proliferation | 0.581 |
PPP1R26 | BTBD9 | ENSP00000349274 | ENSP00000386121 | protein phosphatase 1, regulatory subunit 26; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. May positively regulate cell proliferation | BTB (POZ) domain containing 9 | 0.410 |
PPP1R26 | C4orf19 | ENSP00000349274 | ENSP00000284437 | protein phosphatase 1, regulatory subunit 26; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. May positively regulate cell proliferation | chromosome 4 open reading frame 19 | 0.509 |
PPP1R26 | C7orf50 | ENSP00000349274 | ENSP00000350011 | protein phosphatase 1, regulatory subunit 26; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. May positively regulate cell proliferation | chromosome 7 open reading frame 50 | 0.540 |
PPP1R26 | ESD | ENSP00000349274 | ENSP00000367992 | protein phosphatase 1, regulatory subunit 26; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. May positively regulate cell proliferation | esterase D; Serine hydrolase involved in the detoxification of formaldehyde | 0.440 |
PPP1R26 | HINFP | ENSP00000349274 | ENSP00000318085 | protein phosphatase 1, regulatory subunit 26; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. May positively regulate cell proliferation | histone H4 transcription factor; Transcriptional repressor that binds to the consensus sequence 5’-CGGACGTT-3’ and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter | 0.487 |
PPP1R26 | OR2S2 | ENSP00000349274 | ENSP00000344040 | protein phosphatase 1, regulatory subunit 26; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. May positively regulate cell proliferation | olfactory receptor, family 2, subfamily S, member 2; Odorant receptor (Potential) | 0.581 |