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HADHB HADHB HADHA HADHA CPT2 CPT2 ECHS1 ECHS1 EHHADH EHHADH ACAA2 ACAA2 ACADVL ACADVL GCH1 GCH1 ACAA1 ACAA1 HADH HADH FOXA2 FOXA2
"ACADVL" - acyl-CoA dehydrogenase, very long chain in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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second shell of interactors
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Known Interactions
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Predicted Interactions
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fusion edge
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gene co-occurrence
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textmining
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homology edge
protein homology
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Score
ACADVLacyl-CoA dehydrogenase, very long chain; Active toward esters of long-chain and very long chain fatty acids such as palmitoyl-CoA, mysritoyl-CoA and stearoyl-CoA. Can accommodate substrate acyl chain lengths as long as 24 carbons, but shows little activity for substrates of less than 12 carbons (655 aa)    
Predicted Functional Partners:
HADHA
hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit; Bifunctional subunit (763 aa)
score_image     score_image   score_image score_image   0.994
EHHADH
enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase (723 aa)
score_image     score_image   score_image score_image   0.989
HADHB
hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit (474 aa)
score_image     score_image   score_image score_image   0.981
ECHS1
enoyl CoA hydratase, short chain, 1, mitochondrial; Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate (290 aa)
score_image     score_image   score_image score_image   0.977
ACAA2
acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage (397 aa)
score_image     score_image   score_image score_image   0.976
ACAA1
acetyl-CoA acyltransferase 1 (424 aa)
score_image     score_image   score_image score_image   0.971
CPT2
carnitine palmitoyltransferase 2 (658 aa)
      score_image   score_image score_image   0.971
FOXA2
forkhead box A2; Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a ’pioneer’ factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5’-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3’ (By similarity). In embryonic development is required for notochord formation. Involved in the devel [...] (463 aa)
          score_image score_image   0.902
HADH
hydroxyacyl-CoA dehydrogenase; Plays an essential role in the mitochondrial beta- oxidation of short chain fatty acids. Exerts it highest activity toward 3-hydroxybutyryl-CoA (331 aa)
score_image   score_image score_image     score_image   0.841
GCH1
GTP cyclohydrolase 1; Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown (250 aa)
            score_image   0.802
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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