| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C7orf72 | FIGNL1 | ENSP00000297001 | ENSP00000349356 | chromosome 7 open reading frame 72 | fidgetin-like 1; May regulate osteoblast proliferation and differentiation (By similarity) | 0.587 |
| DEGS2 | FIGNL1 | ENSP00000307126 | ENSP00000349356 | delta(4)-desaturase, sphingolipid 2; Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-hydroxylase (By similarity) | fidgetin-like 1; May regulate osteoblast proliferation and differentiation (By similarity) | 0.612 |
| FIGNL1 | C7orf72 | ENSP00000349356 | ENSP00000297001 | fidgetin-like 1; May regulate osteoblast proliferation and differentiation (By similarity) | chromosome 7 open reading frame 72 | 0.587 |
| FIGNL1 | DEGS2 | ENSP00000349356 | ENSP00000307126 | fidgetin-like 1; May regulate osteoblast proliferation and differentiation (By similarity) | delta(4)-desaturase, sphingolipid 2; Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-hydroxylase (By similarity) | 0.612 |
| FIGNL1 | ITGB1BP1 | ENSP00000349356 | ENSP00000347504 | fidgetin-like 1; May regulate osteoblast proliferation and differentiation (By similarity) | integrin beta 1 binding protein 1; Regulates integrin signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha- 5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. May play a role in the recruitment of ITGB1 to focal contacts during integrin-dependent cell adhesion | 0.613 |
| FIGNL1 | KLF5 | ENSP00000349356 | ENSP00000366915 | fidgetin-like 1; May regulate osteoblast proliferation and differentiation (By similarity) | Kruppel-like factor 5 (intestinal); Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes | 0.622 |
| FIGNL1 | PCNA | ENSP00000349356 | ENSP00000368438 | fidgetin-like 1; May regulate osteoblast proliferation and differentiation (By similarity) | proliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase’s processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3’- 5’ exonuclease and 3’-phosphodiesterase, but not apurinic- apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA re [...] | 0.645 |
| FIGNL1 | RAD1 | ENSP00000349356 | ENSP00000340879 | fidgetin-like 1; May regulate osteoblast proliferation and differentiation (By similarity) | RAD1 homolog (S. pombe); Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3’-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity [...] | 0.604 |
| FIGNL1 | SPOP | ENSP00000349356 | ENSP00000240327 | fidgetin-like 1; May regulate osteoblast proliferation and differentiation (By similarity) | speckle-type POZ protein; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of H2AFY and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation. The cullin-RING-base [...] | 0.603 |
| FIGNL1 | SPOPL | ENSP00000349356 | ENSP00000280098 | fidgetin-like 1; May regulate osteoblast proliferation and differentiation (By similarity) | speckle-type POZ protein-like; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency. Cullin-RING-based BCR (BTB-CUL3- RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL are less efficient than ubiquitin ligase complexes containing only SPOP. May function to down-regulate the activity of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes [...] | 0.603 |
| FIGNL1 | SUMO1 | ENSP00000349356 | ENSP00000376076 | fidgetin-like 1; May regulate osteoblast proliferation and differentiation (By similarity) | SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae); Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. [...] | 0.623 |
| FIGNL1 | UBC | ENSP00000349356 | ENSP00000344818 | fidgetin-like 1; May regulate osteoblast proliferation and differentiation (By similarity) | ubiquitin C | 0.585 |
| ITGB1BP1 | FIGNL1 | ENSP00000347504 | ENSP00000349356 | integrin beta 1 binding protein 1; Regulates integrin signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha- 5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. May play a role in the recruitment of ITGB1 to focal contacts during integrin-dependent cell adhesion | fidgetin-like 1; May regulate osteoblast proliferation and differentiation (By similarity) | 0.613 |
| KLF5 | FIGNL1 | ENSP00000366915 | ENSP00000349356 | Kruppel-like factor 5 (intestinal); Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes | fidgetin-like 1; May regulate osteoblast proliferation and differentiation (By similarity) | 0.622 |
| KLF5 | UBC | ENSP00000366915 | ENSP00000344818 | Kruppel-like factor 5 (intestinal); Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes | ubiquitin C | 0.999 |
| PCNA | FIGNL1 | ENSP00000368438 | ENSP00000349356 | proliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase’s processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3’- 5’ exonuclease and 3’-phosphodiesterase, but not apurinic- apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA re [...] | fidgetin-like 1; May regulate osteoblast proliferation and differentiation (By similarity) | 0.645 |
| PCNA | RAD1 | ENSP00000368438 | ENSP00000340879 | proliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase’s processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3’- 5’ exonuclease and 3’-phosphodiesterase, but not apurinic- apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA re [...] | RAD1 homolog (S. pombe); Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3’-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity [...] | 0.979 |
| PCNA | SUMO1 | ENSP00000368438 | ENSP00000376076 | proliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase’s processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3’- 5’ exonuclease and 3’-phosphodiesterase, but not apurinic- apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA re [...] | SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae); Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. [...] | 0.994 |
| PCNA | UBC | ENSP00000368438 | ENSP00000344818 | proliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase’s processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3’- 5’ exonuclease and 3’-phosphodiesterase, but not apurinic- apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA re [...] | ubiquitin C | 0.999 |
| RAD1 | FIGNL1 | ENSP00000340879 | ENSP00000349356 | RAD1 homolog (S. pombe); Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3’-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity [...] | fidgetin-like 1; May regulate osteoblast proliferation and differentiation (By similarity) | 0.604 |
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