node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CACNA1C | CALM1 | ENSP00000266376 | ENSP00000349467 | calcium channel, voltage-dependent, L type, alpha 1C subunit | calmodulin 1 (phosphorylase kinase, delta) | 0.972 |
CALM1 | CACNA1C | ENSP00000349467 | ENSP00000266376 | calmodulin 1 (phosphorylase kinase, delta) | calcium channel, voltage-dependent, L type, alpha 1C subunit | 0.972 |
CALM1 | CAMK1 | ENSP00000349467 | ENSP00000256460 | calmodulin 1 (phosphorylase kinase, delta) | calcium/calmodulin-dependent protein kinase I; Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippoc [...] | 0.982 |
CALM1 | CSNK2A1 | ENSP00000349467 | ENSP00000217244 | calmodulin 1 (phosphorylase kinase, delta) | casein kinase 2, alpha 1 polypeptide; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly che [...] | 0.974 |
CALM1 | FKBP8 | ENSP00000349467 | ENSP00000222308 | calmodulin 1 (phosphorylase kinase, delta) | FK506 binding protein 8, 38kDa; Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis | 0.972 |
CALM1 | IQGAP1 | ENSP00000349467 | ENSP00000268182 | calmodulin 1 (phosphorylase kinase, delta) | IQ motif containing GTPase activating protein 1; Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth | 0.987 |
CALM1 | IQGAP2 | ENSP00000349467 | ENSP00000274364 | calmodulin 1 (phosphorylase kinase, delta) | IQ motif containing GTPase activating protein 2; Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin | 0.977 |
CALM1 | MYLK | ENSP00000349467 | ENSP00000353452 | calmodulin 1 (phosphorylase kinase, delta) | myosin light chain kinase | 0.971 |
CALM1 | NOS2 | ENSP00000349467 | ENSP00000327251 | calmodulin 1 (phosphorylase kinase, delta) | nitric oxide synthase 2, inducible | 0.970 |
CALM1 | NOS3 | ENSP00000349467 | ENSP00000297494 | calmodulin 1 (phosphorylase kinase, delta) | nitric oxide synthase 3 (endothelial cell); Produces nitric oxide (NO) (By similarity) | 0.993 |
CALM1 | PHKG1 | ENSP00000349467 | ENSP00000297373 | calmodulin 1 (phosphorylase kinase, delta) | phosphorylase kinase, gamma 1 (muscle); Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. In vitro, phosphorylates PYGM, TNNI3, MAPT/TAU, GAP43 and NRGN/RC3 (By similarity) | 0.970 |
CAMK1 | CALM1 | ENSP00000256460 | ENSP00000349467 | calcium/calmodulin-dependent protein kinase I; Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippoc [...] | calmodulin 1 (phosphorylase kinase, delta) | 0.982 |
CAMK1 | NOS3 | ENSP00000256460 | ENSP00000297494 | calcium/calmodulin-dependent protein kinase I; Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippoc [...] | nitric oxide synthase 3 (endothelial cell); Produces nitric oxide (NO) (By similarity) | 0.817 |
CSNK2A1 | CALM1 | ENSP00000217244 | ENSP00000349467 | casein kinase 2, alpha 1 polypeptide; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly che [...] | calmodulin 1 (phosphorylase kinase, delta) | 0.974 |
FKBP8 | CALM1 | ENSP00000222308 | ENSP00000349467 | FK506 binding protein 8, 38kDa; Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis | calmodulin 1 (phosphorylase kinase, delta) | 0.972 |
IQGAP1 | CALM1 | ENSP00000268182 | ENSP00000349467 | IQ motif containing GTPase activating protein 1; Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth | calmodulin 1 (phosphorylase kinase, delta) | 0.987 |
IQGAP2 | CALM1 | ENSP00000274364 | ENSP00000349467 | IQ motif containing GTPase activating protein 2; Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin | calmodulin 1 (phosphorylase kinase, delta) | 0.977 |
MYLK | CALM1 | ENSP00000353452 | ENSP00000349467 | myosin light chain kinase | calmodulin 1 (phosphorylase kinase, delta) | 0.971 |
MYLK | NOS3 | ENSP00000353452 | ENSP00000297494 | myosin light chain kinase | nitric oxide synthase 3 (endothelial cell); Produces nitric oxide (NO) (By similarity) | 0.537 |
NOS2 | CALM1 | ENSP00000327251 | ENSP00000349467 | nitric oxide synthase 2, inducible | calmodulin 1 (phosphorylase kinase, delta) | 0.970 |