node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDC20 | RASSF1 | ENSP00000308450 | ENSP00000349547 | cell division cycle 20 homolog (S. cerevisiae); Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1- in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic dif [...] | Ras association (RalGDS/AF-6) domain family member 1 | 0.979 |
CNKSR1 | MOAP1 | ENSP00000354609 | ENSP00000298894 | connector enhancer of kinase suppressor of Ras 1; May function as an adapter protein or regulator of Ras signaling pathways | modulator of apoptosis 1; Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation | 0.407 |
CNKSR1 | RASSF1 | ENSP00000354609 | ENSP00000349547 | connector enhancer of kinase suppressor of Ras 1; May function as an adapter protein or regulator of Ras signaling pathways | Ras association (RalGDS/AF-6) domain family member 1 | 0.973 |
CNKSR1 | STK3 | ENSP00000354609 | ENSP00000390500 | connector enhancer of kinase suppressor of Ras 1; May function as an adapter protein or regulator of Ras signaling pathways | serine/threonine kinase 3; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, wh [...] | 0.685 |
CNKSR1 | STK4 | ENSP00000354609 | ENSP00000361892 | connector enhancer of kinase suppressor of Ras 1; May function as an adapter protein or regulator of Ras signaling pathways | serine/threonine kinase 4; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, wh [...] | 0.657 |
E4F1 | RASSF1 | ENSP00000301727 | ENSP00000349547 | E4F transcription factor 1; May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination of chromatin-associated TP53. Functions in cell survival and proliferation through control of the cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription | Ras association (RalGDS/AF-6) domain family member 1 | 0.947 |
HRAS | KRAS | ENSP00000309845 | ENSP00000256078 | v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.901 |
HRAS | MDM2 | ENSP00000309845 | ENSP00000417281 | v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) | 0.566 |
HRAS | MLH1 | ENSP00000309845 | ENSP00000231790 | v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli); Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS- heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to deg [...] | 0.728 |
HRAS | RASSF1 | ENSP00000309845 | ENSP00000349547 | v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | Ras association (RalGDS/AF-6) domain family member 1 | 0.987 |
KRAS | HRAS | ENSP00000256078 | ENSP00000309845 | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.901 |
KRAS | MDM2 | ENSP00000256078 | ENSP00000417281 | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) | 0.507 |
KRAS | MLH1 | ENSP00000256078 | ENSP00000231790 | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli); Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS- heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to deg [...] | 0.757 |
KRAS | RASSF1 | ENSP00000256078 | ENSP00000349547 | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | Ras association (RalGDS/AF-6) domain family member 1 | 0.936 |
MDM2 | HRAS | ENSP00000417281 | ENSP00000309845 | Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) | v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.566 |
MDM2 | KRAS | ENSP00000417281 | ENSP00000256078 | Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.507 |
MDM2 | RASSF1 | ENSP00000417281 | ENSP00000349547 | Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) | Ras association (RalGDS/AF-6) domain family member 1 | 0.967 |
MLH1 | HRAS | ENSP00000231790 | ENSP00000309845 | mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli); Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS- heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to deg [...] | v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.728 |
MLH1 | KRAS | ENSP00000231790 | ENSP00000256078 | mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli); Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS- heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to deg [...] | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.757 |
MLH1 | RASSF1 | ENSP00000231790 | ENSP00000349547 | mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli); Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS- heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to deg [...] | Ras association (RalGDS/AF-6) domain family member 1 | 0.949 |