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STRINGSTRING
SPTBN1 SPTBN1 NRCAM NRCAM SPTA1 SPTA1 SPTAN1 SPTAN1 SPTBN4 SPTBN4 NFASC NFASC KCNQ2 KCNQ2 ANK2 ANK2 ITPR2 ITPR2 ITPR3 ITPR3 ITPR1 ITPR1
"ANK2" - ankyrin 2, neuronal in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
ANK2ankyrin 2, neuronal; In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions (By similarity). Attaches integral membrane proteins to cytoskeletal elements. Also binds to cytoskeletal proteins. Required for coordinate assembly of Na/Ca exchanger, Na/K ATPase and InsP3 receptor at sarcoplasmic reticulum sites in cardiomyocytes. Required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) in the inner se [...] (3957 aa)    
Predicted Functional Partners:
NRCAM
neuronal cell adhesion molecule; Cell adhesion, ankyrin-binding protein involved in neuron-neuron adhesion. May play a role in the molecular assembly of the nodes of Ranvier (By similarity) (1304 aa)
      score_image score_image score_image score_image   0.992
NFASC
neurofascin (1240 aa)
      score_image score_image score_image score_image   0.990
SPTBN1
spectrin, beta, non-erythrocytic 1; Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane (2364 aa)
      score_image score_image score_image score_image   0.968
ITPR1
inositol 1,4,5-trisphosphate receptor, type 1; Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity) (2743 aa)
        score_image score_image score_image   0.952
ITPR2
inositol 1,4,5-trisphosphate receptor, type 2; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity) (2701 aa)
        score_image score_image score_image   0.947
SPTAN1
spectrin, alpha, non-erythrocytic 1 (2477 aa)
      score_image score_image score_image score_image   0.934
ITPR3
inositol 1,4,5-trisphosphate receptor, type 3; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium (2671 aa)
        score_image score_image score_image   0.933
KCNQ2
potassium voltage-gated channel, KQT-like subfamily, member 2 (872 aa)
          score_image score_image   0.921
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2); Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane (2419 aa)
      score_image score_image score_image score_image   0.920
SPTBN4
spectrin, beta, non-erythrocytic 4 (2564 aa)
      score_image score_image score_image score_image   0.913
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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