MCRS1 protein (Homo sapiens) - STRING network view

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MCRS1

microspherule protein 1; Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity (475 aa)

Predicted Functional Partners:

INO80E

0.991

NFRKB

0.980

INO80

0.978

CHD4

0.976

UCHL5

0.975

KANSL2

0.967

KAT8

0.965

INO80C

0.960

KANSL3

0.960

INO80B

0.958

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHD4	INO80	ENSP00000349508	ENSP00000355205	chromodomain helicase DNA binding protein 4; Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones	INO80 homolog (S. cerevisiae); DNA helicase and probable main scaffold component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; according to PubMed-20687897 the contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Recruited by YY1 to YY1-activated genes, where it acts as an essential coactivator. Binds DNA. In vitro, has double stranded DNA-dependent ATPase activity. Involved in UV-damage excision repair, DNA replication and chromosome segreg [...]	0.418
CHD4	KAT8	ENSP00000349508	ENSP00000406037	chromodomain helicase DNA binding protein 4; Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones	K(lysine) acetyltransferase 8	0.450
CHD4	MCRS1	ENSP00000349508	ENSP00000349640	chromodomain helicase DNA binding protein 4; Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones	microspherule protein 1; Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity	0.976
INO80	CHD4	ENSP00000355205	ENSP00000349508	INO80 homolog (S. cerevisiae); DNA helicase and probable main scaffold component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; according to PubMed-20687897 the contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Recruited by YY1 to YY1-activated genes, where it acts as an essential coactivator. Binds DNA. In vitro, has double stranded DNA-dependent ATPase activity. Involved in UV-damage excision repair, DNA replication and chromosome segreg [...]	chromodomain helicase DNA binding protein 4; Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones	0.418
INO80	INO80B	ENSP00000355205	ENSP00000233331	INO80 homolog (S. cerevisiae); DNA helicase and probable main scaffold component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; according to PubMed-20687897 the contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Recruited by YY1 to YY1-activated genes, where it acts as an essential coactivator. Binds DNA. In vitro, has double stranded DNA-dependent ATPase activity. Involved in UV-damage excision repair, DNA replication and chromosome segreg [...]	INO80 complex subunit B; Induces growth and cell cycle arrests at the G1 phase of the cell cycle	0.978
INO80	INO80C	ENSP00000355205	ENSP00000391457	INO80 homolog (S. cerevisiae); DNA helicase and probable main scaffold component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; according to PubMed-20687897 the contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Recruited by YY1 to YY1-activated genes, where it acts as an essential coactivator. Binds DNA. In vitro, has double stranded DNA-dependent ATPase activity. Involved in UV-damage excision repair, DNA replication and chromosome segreg [...]	INO80 complex subunit C; Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair	0.999
INO80	INO80E	ENSP00000355205	ENSP00000457016	INO80 homolog (S. cerevisiae); DNA helicase and probable main scaffold component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; according to PubMed-20687897 the contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Recruited by YY1 to YY1-activated genes, where it acts as an essential coactivator. Binds DNA. In vitro, has double stranded DNA-dependent ATPase activity. Involved in UV-damage excision repair, DNA replication and chromosome segreg [...]	INO80 complex subunit E; Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair	0.989
INO80	MCRS1	ENSP00000355205	ENSP00000349640	INO80 homolog (S. cerevisiae); DNA helicase and probable main scaffold component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; according to PubMed-20687897 the contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Recruited by YY1 to YY1-activated genes, where it acts as an essential coactivator. Binds DNA. In vitro, has double stranded DNA-dependent ATPase activity. Involved in UV-damage excision repair, DNA replication and chromosome segreg [...]	microspherule protein 1; Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity	0.978
INO80	NFRKB	ENSP00000355205	ENSP00000436926	INO80 homolog (S. cerevisiae); DNA helicase and probable main scaffold component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; according to PubMed-20687897 the contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Recruited by YY1 to YY1-activated genes, where it acts as an essential coactivator. Binds DNA. In vitro, has double stranded DNA-dependent ATPase activity. Involved in UV-damage excision repair, DNA replication and chromosome segreg [...]	nuclear factor related to kappaB binding protein; Binds to the DNA consensus sequence 5’-GGGGAATCTCC-3’	0.999
INO80	UCHL5	ENSP00000355205	ENSP00000356425	INO80 homolog (S. cerevisiae); DNA helicase and probable main scaffold component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; according to PubMed-20687897 the contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Recruited by YY1 to YY1-activated genes, where it acts as an essential coactivator. Binds DNA. In vitro, has double stranded DNA-dependent ATPase activity. Involved in UV-damage excision repair, DNA replication and chromosome segreg [...]	ubiquitin carboxyl-terminal hydrolase L5; Protease that specifically cleaves ’Lys-48’-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1	0.974
INO80B	INO80	ENSP00000233331	ENSP00000355205	INO80 complex subunit B; Induces growth and cell cycle arrests at the G1 phase of the cell cycle	INO80 homolog (S. cerevisiae); DNA helicase and probable main scaffold component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; according to PubMed-20687897 the contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Recruited by YY1 to YY1-activated genes, where it acts as an essential coactivator. Binds DNA. In vitro, has double stranded DNA-dependent ATPase activity. Involved in UV-damage excision repair, DNA replication and chromosome segreg [...]	0.978
INO80B	INO80C	ENSP00000233331	ENSP00000391457	INO80 complex subunit B; Induces growth and cell cycle arrests at the G1 phase of the cell cycle	INO80 complex subunit C; Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair	0.973
INO80B	INO80E	ENSP00000233331	ENSP00000457016	INO80 complex subunit B; Induces growth and cell cycle arrests at the G1 phase of the cell cycle	INO80 complex subunit E; Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair	0.990
INO80B	MCRS1	ENSP00000233331	ENSP00000349640	INO80 complex subunit B; Induces growth and cell cycle arrests at the G1 phase of the cell cycle	microspherule protein 1; Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity	0.958
INO80B	NFRKB	ENSP00000233331	ENSP00000436926	INO80 complex subunit B; Induces growth and cell cycle arrests at the G1 phase of the cell cycle	nuclear factor related to kappaB binding protein; Binds to the DNA consensus sequence 5’-GGGGAATCTCC-3’	0.960
INO80B	UCHL5	ENSP00000233331	ENSP00000356425	INO80 complex subunit B; Induces growth and cell cycle arrests at the G1 phase of the cell cycle	ubiquitin carboxyl-terminal hydrolase L5; Protease that specifically cleaves ’Lys-48’-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1	0.935
INO80C	INO80	ENSP00000391457	ENSP00000355205	INO80 complex subunit C; Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair	INO80 homolog (S. cerevisiae); DNA helicase and probable main scaffold component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; according to PubMed-20687897 the contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Recruited by YY1 to YY1-activated genes, where it acts as an essential coactivator. Binds DNA. In vitro, has double stranded DNA-dependent ATPase activity. Involved in UV-damage excision repair, DNA replication and chromosome segreg [...]	0.999
INO80C	INO80B	ENSP00000391457	ENSP00000233331	INO80 complex subunit C; Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair	INO80 complex subunit B; Induces growth and cell cycle arrests at the G1 phase of the cell cycle	0.973
INO80C	INO80E	ENSP00000391457	ENSP00000457016	INO80 complex subunit C; Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair	INO80 complex subunit E; Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair	0.992
INO80C	KAT8	ENSP00000391457	ENSP00000406037	INO80 complex subunit C; Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair	K(lysine) acetyltransferase 8	0.900

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